Apolipoprotein E in the brain and its role in alzheimer's disease

Journal of Psychiatry and Neuroscience

Volumn 21, Issue 2, 1996, Pages 128-134

  Poirier, Judes ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

Alzheimer's disease; Apolipoprotein E; Cholesterol; Human; LDL receptors; Lipid; Synaptic plasticity

Indexed keywords

APOLIPOPROTEIN E; CHOLESTEROL;

AGED; ALLELE; ALZHEIMER DISEASE; ARTICLE; BLOOD; BRAIN; COMPARATIVE STUDY; FEMALE; HIPPOCAMPUS; HUMAN; MALE; METABOLISM; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY; SYNAPSE;

AGED; ALLELES; ALZHEIMER DISEASE; APOLIPOPROTEINS E; BRAIN; CHOLESTEROL; FEMALE; HIPPOCAMPUS; HUMANS; MALE; MIDDLE AGED; SYNAPSES;

EID: 0030092881     PISSN: 11804882     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Bertrand P, Poirier J, Oda T, Finch CE, Pasinetti GM. 1995. Association between apolipoprotein E genotype with brain levels of apolipoprotein E and apolipoprotein J (clusterin) in Alzheimer's disease. Mol Brain Res. Forth-coming.
2. Blennow K, Hesse C, Fredman P. 1994. Cerebrospinal fluid apolipoprotein E is reduced in Alzheimer's disease. Neuroreport 5:2534-2536.
3. 1, and low density lipoprotein receptors in cholesterol transport during regeneration and remyelination of rat sciatic nerve. J Clin Invest 83:1015-1031.
4. Breteler MMB, Claus JJ, Duijn CMV. 1992. Epidemiology of Alzheimer's disease. Epid Review 14:59-82.
5. Brown MS, Dana SE, Goldstein JL. 1973. Regulation of 3-hydroxy-3methylglutarylcoenzyme A reductase activity in human fibroblasts by lipoproteins. Proc Natl Acad Sci USA 70:2162-2166.
6. Brown MS, Goldstein JL. 1986. A receptor mediated pathway for cholesterol homeostasis. Science 232:34-47.
7. Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, Roses AD, Pericak-Vance MA. 1993. Gene dose of apolipoprotein E type 4 and risk of Alzheimer's disease in late onset families. Science 261:921-923.
8. Davies P, Maloney A JR. 1976. Selective loss of central cholinergic neurons in Alzheimer's disease. Lancet 2:1403-1408.
9. Davignon J, Gregg RE, Sing CF. 1988. Apolipoprotein E polymorphism and atherosclerosis. Arteriosclerosis 8:1-21.
10. de Ruiter JP, Uylings HB. 1987. Morphometric and dendritic analysis of fascia dentata granule cells in human aging and senile dementia. Brain Res 402:217-229.
11. Flood DG, Coleman PD. 1986. Failed compensatory dendritic growth as a physiological process in Alzheimer's disease. Can J Neural Sci 13:475-479.
12. Geddes JW, Monaghan DT, Cotman CW, Lott IT, Kim RC, Chui HC. 1985. Plasticity of hippocampal circuitry in Alzheimer's disease. Science 230:1179-1181.
13. Gerdes LU, Klausen C, Sihm I, Faergeman O. 1992. Apolipoprotein E polymorphism in a Danish population compared to findings in 45 other study populations around the world. Gen Epidem 9:155-167.
14. Goodrum JF. 1990. Cholesterol synthesis is down-regulated during regeneration of peripheral nerve. J Neurochem 54:1709-1715.
15. Guillaume D, Dea D, Davignon J, Poirier J. 1995. Low density lipoprotein pathways in the central nervous system and apolipoprotein E isoform-specific differences. In: Iqbal K, Mortimer JA, Winblad B, Winiewski H, editors. Research advances in Alzheimer's disease and related disorders. London: John Wiley and Sons, p 4-395.