Deposition of eosinophil granule proteins precedes blister formation in bullous pemphigoid: Comparison with neutrophil and mast cell granule proteins

American Journal of Pathology

Volumn 148, Issue 3, 1996, Pages 897-909

  Borrego, Leopoldo ^a   Maynard, Bruno ^b   Peterson, Ellen A ^b   George, Terry ^b   Iglesias, Luis ^a   Peters, Margot S ^b   Newman, Walter ^c   Gleich, Gerald J ^a   Leiferman, Kristin M ^a,b  

^a HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

^b MAYO CLINIC   (United States)

^c Otsuka America Pharmaceutical   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTACOID; CELL ADHESION MOLECULE; CYTOKINE; EOSINOPHIL GRANULE PROTEIN; PLASMA PROTEIN; RIBONUCLEASE;

AGED; ARTICLE; BLISTER; BULLOUS PEMPHIGOID; COMPARATIVE STUDY; ELECTRON MICROSCOPY; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HUMAN; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY; RETROSPECTIVE STUDY;

AGED; AGED, 80 AND OVER; BLISTER; BLOOD PROTEINS; CELL ADHESION MOLECULES; CYTOKINES; EOSINOPHIL GRANULE PROTEINS; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; INFLAMMATION MEDIATORS; MALE; MICROSCOPY, ELECTRON; MIDDLE AGED; PEMPHIGOID, BULLOUS; RETROSPECTIVE STUDIES; RIBONUCLEASES;

EID: 0030091629     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Korman N Bullous pemphigoid J Ann Acad Dermatol 1987, 16:907-924
2. Czech W, Schaller J, Schopf E, Kapp A: Granulocyte activation in bullous diseases, release of granular proteins in bullous pemphigoid and pemphigus vulgaris. J Am Acad Dermatol 1993, 29 210-215
3. Tsuda S, Miyasalo M, Iryo K, Nakama T, Kato K, Sasai Y: Eosinophil phenotypes in bullous pemphigoid. J Dermatol 1992, 19:270-279
4. Wintroub BU, Dvorak AM, Mihm MC, Gleich GJ Bullous pemphigoid cytotoxic eosinophil degranulation and release of eosinophil major basic protein (abstract) J Invest Dermatol 1981, 76:310
5. Cox NH, Cooper PN, Venge P, Friedman PS: Eosinophil cationic protein in bullous pemphigoid, dermatitis herpetiformis and other blistering disorders Eur J Dermatol 1993, 3.294-298
6. Stahle-Backdahl M, Inoue M, Giudice GJ, Parks WC. 92-kD gelatinase is produced by eosinophils at the site of blister formation in bullous pemphigoid and cleaves the extracellular domain of recombinant 180-kD bullous pemphigoid autoantigen. J Clin Invest 1994, 93.2022-2030
7. Filley WV, Ackerman SJ, Gleich GJ: An immunofluorescent method for specific staining of eosinophil major basic protein J Immunol Methods 1981, 47:227-238
8. Peters MS, Schroeter AL, Kephart GM, Gleich GJ Localization of eosinophil granule major basic protein in chronic urticaria J Invest Dermatol 1983, 81:39-43
9. Leiferman KM, Fujisawa T, Gray BH. Gleich GJ. Extracellular deposition of eosinophil and neutrophil granule proteins in the IgE-mediated cutaneous late phase reaction Lab Invest 1990, 62:579-589
10. Perez GL, Peters MS, Reda AM, Butterfield JH, Peterson EA, Leiferman KM. Mast cells, neutrophils, and eosinophils in prurigo nodularis. Arch Dermatol 1993, 129.861-866
11. Johnson NW, Bienenstock J: Abolition of nonspecific fluorescent staining of eosinophils J Immunol Methods 1974, 2 189-194
12. Krenik KD, Kephart GM, Offord KP, Dunnette SL, Gleich GJ. Comparison of antifading agents used in immunofluorescence. J Immunol Methods 1989, 117: 91-97
13. Bergstresser PR, Tigelaar RE, Tharp MD. Conjugated avidin identifies cutaneous rodent and human mast cells J Invest Dermatol 1984, 83:214-218
14. Bochner BS, Luscinskas FW, Gimbrone MA Jr. Newman W, Sherbinsky SA, Derse-Anthony CP, Klunk D, Schleimer RP Adhesion of human basophils, eosinophils and neutrophils to interieukm-1 activated human vascular endothelial cells contributions of endothelial cell adhesion molecules J Exp Med 1991, 173 1553-1557
15. Graber N, Gopal TV, Wilson D, Beall LD, Polte T, Newman W T cells bind to cytokine-activated endothelial cells via a novel inclucible sialoglycoprotein and endothelial leukocyte adhesion molecule-1 J Immunol 1990, 145:819-830
16. Maddox DE, Butterfieid JH, Ackerman SJ, Coulam CB, Gleich GJ: Elevated serum levels in human pregnancy of molecule immunochemicaily similar to eosinophil granule major basic protein. J Exp Med 1983, 158 1211-1226
17. Abu-Ghazaleh RI, Dunnette SL, Loegering DA, Checkel JL, Kita H, Thomas LL, Gleich GJ: Eosinophil granule proteins in peripheral blood granulocytes J Leukocyte Biol 1992, 52611-618
18. Wagner JM, Bartemes K, Vernof KK, Dunnette S, Offord KP, Checkel JL, Gleich GJ: Analysis of pregnancy-associated major basic protein levels throughout gestation Placenta 1993, 14:671-681
19. Kita H, Ohnishi T, Okubo Y, Weiler D, Abrams JS, Gleich GJ: Granulocyte/macrophage colony-stimulating factor and interleukin 3 release from human peripheral blood eosinophils and neutrophils. J Exp Med 1991, 174;745-748
20. Pehamberger H, Gschnait F, Konrad K, Holubar K Bullous pemphigoid, herpes gestationis and linear dermatitis herpetiformis: circulating anti-basement membrane zone antibodies, in vitro studies. J Invest Dermatol 1980, 74:105-108
21. Sams WM Jr, Gammon WR: Mechanism of lesion production in pemphigus and pemphigoid. J Am Acad Dermatol 1982, 6.431-452
22. Schmidt-Ullrich B, Rule A, Schaumburg-Lever G, Leblanc C: Ultrastructural localization of in vivo bound complement in bullous pemphigoid J Invest Dermatol 1975, 65:217-219
23. Carlo JR, Gammon WR, Sams SM, Ruddy S. Demonstration of the complement regulating protein, BIH, in skin biopsies from patients with bullous pemphigoid J Invest Dermatol 1979, 73:551-553
24. Jordon RE, Nordby JM, Milstein H: The complement system in bullous pemphigoid: fixation of Clq and C4 by pemphigoid antibody. J Lab Clin Med 1975, 86 733-740
25. Provost TT, Tomasi TB. Evidence for complement activation via the alternate pathway in skin disease herpes gestationis, systemic lupus erythematosus and bullous pemphigoid J Clin Invest 1973, 52 1779-1787
26. Gammon WR, Merntt CC, Lewis DM, Sams WM, Wheeler CE, Carlo J: Leukocyte chemotaxis to dermalepidermal junction of human skin mediated by pemphigoid antibody and complement mechanism of cell attachment in the in vitro leukocyte attachment method J Invest Dermatol 1981, 76 514-522
27. Dahl MV, Falk RJ, Carpenter R, Michael AF: Deposition of the membrane attack complex of complement in bullous pemphigoid J Invest Dermatol 1984, 82: 132-135
28. Liu Z, Diaz LA. Troy JL, Taylor AF, Emery DJ, Fairley JA, Giudice GJ: A passive transfer model of the organspecific autoimmune disease, bullous pemphigoid, using antibodies generated against the hemidesmosomal antigen, BP180 J Clin Invest 1993, 92:2480-2488
29. Gammon WR, Merritt CC, Lewis DM, Sams WM, Carlo JR, Wheeler CE. An in vitro model of immune complex-mediated basement membrane zone separation caused by pemphigoid antibodies, leukocytes, and complement. J Invest Dermatol 1982, 78:285-290
30. Wintroub BU, Mihm MC, Goetzl EJ, Soter NA, Austen KF. Morphologic and functional evidence for release of mast cell products in bullous pemphigoid N Engl J Med 1978, 298.417-421
31. Dvorak AM, Mihm MC, Osage JE, Kwan TH, Austen KF, Wintroub BU: Bullous pemphigoid, an ultrastructural study of the inflammatory response: eosinophil, basophil and mast cell granule changes in multiple biopsies from one patient J Invest Dermatol 1982, 78:91-101
32. Wintroub BU, Wasserman SI: The molecular pathogenesis of bullous pemphigoid Clin Dermatol 1987, 5.126-134
33. Goldstein SM, Wasserman SI, Wintroub BU. Mast cell and eosinophil mediated damage in bullous pemphigoid. Immunol Ser 1989, 46:527-545
34. Dubertret L, Bertaux B, Fosse M, Touraine R Cellular events leading to blister formation in bullous pemphigoid Br J Dermatol 1980, 104 615-624
35. Iryo K, Tsuda S, Sasai Y Ultrastructural aspects of infiltrated eosinophils in bullous pemphigoid. J Dermatol 1992, 19:393-399
36. Gleich GJ, Adolphson CR, Leiferman KM. The biology of the eosinophilic leukocyte. Annu Rev Med 1993, 44 85-101
37. Naito K, Moriko S, Ogawa H: The pathogenic mechanisms of blister formation in bullous pemphigoid, J Invest Dermatol 1982, 79:303-306
38. Miyasato M, Tsuda S, Kasada M, Kryo K, Sasai Y. Alteration in the density, morphology, and biological properties of eosinophils produced by bullous pemphigold blister fluid. Arch Dermatol Res 1989, 281-304-309
39. Varigos GA, Morstyn G, Vadas MA: Bullous pemphigoid blister fluid stimulates eosinophil colony formation and activates eosinophils. Clin Exp Immunol 1982, 50. 555-562
40. Silberstein DS, Austen KF, Owen WF Jr. Hematopoietins for eosinophils glycoprotein hormones that regulate the development of inflammation in eosinophilia-associated diseases. Hematol Oncol Clin N Am 1989, 3.511-533
41. Yamaguchi Y, Hayashi Y, Sugama Y, Miura Y, Kasahara T, Kitamura S. Highly purified murine interleukin 5 (IL-5) stimulates eosinophil function and prolongs in vitro survival IL-5 as an eosinophil chemotactic factor. J Exp Med 1988, 167.1737-1742
42. Tamaki K, So K, Furuya T, Furue M Cytokine profile of patients with bullous pemphigoid. Br J Dermatol 1994, 130:128-129
43. Moqbel R, Levi-Schaffer F, Kay AB Cytokine generation by eosinophils. J Allergy Clin Immunol 1994, 94. 1183-1188
44. Schleimer RP, Ebisawa M, Georas SN, Bochner BS: The role of adhesion molecules and cytokines in eosinophil recruitment. Eosinophils in Allergy and Inflammation. Edited by GJ Gleich, AB Kay. New York, Marcel Dekker, 1994, pp 115-132
45. Vadas MA, Lucas CM, Gamble JR, Lopez AF, Skinner MP, Berndt MC. Regulation of eosinophil function by P-selectin. Eosinophils in Allergy and Inflammation. Edited by GJ Gleich, AB Kay. New York, Marcel Dekker, 1994, pp 69-79
46. Moy JN, Gleich GJ, Thomas LL. Noncytotoxic activation of neutrophils by eosinophil granule major basic protein: effect on superoxide anion generation and lysosomal enzyme release J Immunol 1990, 145:2626-2632