Increasing the efficiency of genomic searches for linkage in complex disorders by DNA pooling of affected sib-pairs

Molecular Psychiatry

Volumn 1, Issue 1, 1996, Pages 59-64

  Craddock, N ^a   Daniels, J ^a   Holmans, P ^a   Williams, N ^a   Owen, M J ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Bipolar disorder; DNA pooling; Genetic epidemiology; Genome scan; Schizophrenia; Sib pair linkage analysis

Indexed keywords

DNA;

ARTICLE; BIPOLAR DISORDER; COMPARATIVE STUDY; GENETIC LINKAGE; GENETIC MARKER; GENETIC SCREENING; GENETICS; GENOME; GENOTYPE; HUMAN; METHODOLOGY; NUCLEAR FAMILY; SCHIZOPHRENIA; STANDARD;

BIPOLAR DISORDER; DNA; GENETIC MARKERS; GENETIC SCREENING; GENOME; GENOTYPE; HUMANS; LINKAGE (GENETICS); NUCLEAR FAMILY; SCHIZOPHRENIA;

EID: 0030090432     PISSN: 13594184     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Owen MJ, Craddock N. Modern molecular genetic approaches to complex traits: implications for psychiatric disorders. Mol Psychiatry 1995; 1: 21-26.
2. Davies JL et al. A genome-wide search for human type 1 diabetes susceptibility genes. Nature 1994; 371: 130-136.
3. Elston RC. P values, power, and pitfalls in the linkage analysis of psychiatric disorders. In: Gershon ES, Cloninger CR (eds). Genetic Approaches to Mental Disorders. American Psychiatric Press: Washington. DC, 1994, pp 3-21.
4. Brown DL, Gorin MB, Weeks DE. Efficient strategies for genomic searching using the Affected-Pedigree-Member method for linkage analysis. Am J Hum Gen 1994; 54: 544-552.
5. Holmans P, Craddock N. Strategies for efficient genome screening using maximum likelihood sib-pair analysis. Psychiat Gen 1995; 5: S106.
6. Risch N. Linkage strategies for genetically complex traits. III. The effect of marker polymorphism on analysis of affected relative pairs. Am J Hum Gen 1990; 46: 242-253.
7. Holmans P. Asymptotic properties of affected-sib-pair linkage analysis. Am J Hum Gen 1993; 52: 362-374.
8. APA. Diagnostic and Statistical Manual of Mental Disorders, 3rd edn, revised. American Psychiatric Association; Washington, DC, 1987, 567 pp.
9. Holmans P, Clayton D. Efficiency of typing unaffected relatives in an affected sib-pair linkage study with single locus and multiple tightly-linked markers. Am J Hum Gen 1995; 57: 1221-1232.
10. Risch N. Linkage strategies for genetically complex traits. I. Multilocus models. Am J Hum Gen 1990; 46: 222-228.
11. Craddock N, Khodel V, Van Eerdewegh P, Reich T. Mathematical limits of multilocus models: the genetic transmission of bipolar disorder. Am J Hum Gen 1995; 57: 690-702.
12. Pacek PA, Samantila A, Syvanen A. Determination of allele frequencies at loci with length polymorphism by quantitative analysis of DNA amplified from pooled samples. PCR Meth Appl 1993; 2; 313-317.
13. Darvasi A, Soller M. Selective DNA pooling for determination of linkage between a molecular marker and a quantitative trait locus. Genetics 1994; 138: 1365.
14. LeDuc C, Miller P, Lichter J, Parry P. Batched analysis of genotypes. Research 1995; 4: 331-336.
15. Daniels JK et al. Selective DNA pooling using automated technology: a rapid technique for allelic association studies in quantitative traits and complex diseases. Psychiat Gen 1995; 5: 839.
16. Sheffield VC et al. Identification of a Bardet-Biedl syndrome locus on chromosome 3 and evaluation of an efficient approach to homozygosity mapping. Hum Mol Gen 1994; 3: 1331-1335.
17. Bishop DT, Williamson JA. The power of identity-by-state methods for linkage analysis. Am J Hum Gen 1990; 46: 254-265.
18. Hodge SE. The information contained in multiple sibling pairs. Gen Epidemiol 1984; 1: 109-122.
19. Payami H et al. The affected sib method. IV. Sib trios. Ann Hum Gen 1985; 49: 303-314.