123I-interleukin-2 scintigraphy: A new approach to assess disease activity in autoimmunity

Journal of Pediatric Endocrinology and Metabolism

Volumn 9, Issue SUPPL. 1, 1996, Pages 139-144

  Signore, Alberto ^a,c   Picarelli, Antonio ^a   Chianelli, Marco ^a   Biancone, Livia ^a   Annovazzi, Alessio ^a   Tiberti, Claudio ^a   Anastasi, Emanuela ^a   Multari, Giuseppe ^a   Negri, Marcello ^a   Pallone, Francesco ^b   Pozzilli, Paolo ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY MEDITERRANEA OF REGGIO CALABRIA   (Italy)

^c POLICLINICO UMBERTO I   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 2; IODINE 123; DIAGNOSTIC AGENT; INTERLEUKIN 2 RECEPTOR; RADIOACTIVE IODINE; RECOMBINANT PROTEIN;

ADOLESCENT; ADULT; AUTOIMMUNITY; CELIAC DISEASE; CHRONIC INFLAMMATION; CONFERENCE PAPER; CROHN DISEASE; DISEASE ACTIVITY; FEMALE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MALE; METHODOLOGY; SCINTISCANNING; T LYMPHOCYTE; ABDOMEN; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNE THYROIDITIS; CHILD; COMPARATIVE STUDY; GRAVES DISEASE; INTRAVENOUS DRUG ADMINISTRATION; METABOLISM; MIDDLE AGED; NECK; PHYSIOLOGY;

ABDOMEN; ADOLESCENT; ADULT; AUTOIMMUNE DISEASES; AUTOIMMUNITY; CELIAC DISEASE; CHILD; CROHN DISEASE; FEMALE; GRAVES DISEASE; HUMANS; INJECTIONS, INTRAVENOUS; INTERLEUKIN-2; IODINE RADIOISOTOPES; MALE; MIDDLE AGED; NECK; RECEPTORS, INTERLEUKIN-2; RECOMBINANT PROTEINS; THYROIDITIS, AUTOIMMUNE;

EID: 0030090206     PISSN: 0334018X     EISSN: None     Source Type: Journal    
DOI: 10.1515/jpem.1996.9.s1.139     Document Type: Article

References (16)

1. Signore A, Cooke A, Pozzilli P, Butcher G, Simpson E, Beverley CPL. Class II and IL2 receptor positive cells in the pancreas of NOD mice. Diabetologia 1987; 30: 902-905.
2. Pallone F, Fais S, Squarcia O, Biancone L, Pozzilli P, Boirivant M. Activation of peripheral and intestinal lamina propria lymphocytes in Crohn's disease. In vivo state of activation and in vitro response to stimulation as defined by the expression of early activation antigens Gut 1987; 28: 745-749.
3. Selby WS, Janossy G, Bosil M, Jewell DP. Intestinal lymphocyte subpopulations in inflammatory bowel disease: an analysis by immunohistological and cell isolation techniques. Gut 1984, 25: 32-40.
4. Choy MY, Walker-Smith JA, Williams CB, McDonald TT. Differential expression of CD25 (interleukin-2 receptor) on lamina propria T cells and macrophages in the intestinal lesions in Crohn's disease and ulcerative colitis. Gut 1990; 31: 1365-1370
5. Wall JR, Baur R, Schleusener H, Bandy-Dafoe P. Peripheral blood and intrathyroidal mononuclear cell populations in patients with autoimmune thyroid disorders enumerated using monoclonal antibodies. J Clin Endocrinol Metab 1983; 56: 164-168.
6. Signore A, Parman A, Pozzilli P, Andreani D, Beverley PCL. Detection of activated lymphocytes in endocrine pancreas of BB/W rats by injection or 123-interleukin-2. an early sign of type 1 diabetes. Lancet 1987; 2: 537-540.
7. 123I labelled interleukin-2. Eur J Endocrinol 1994; 131: 431-437.
8. Pallone F, Ricci R, Boirivant M, Montano S. Measuring the activity of Crohn's disease. Ital J Gastroenterol 1981; 13: 51-52.
9. 123I-interleukin-2. Labeling procedure and animal studies. Nucl Med Commun 1992, 13: 713-22
10. Konrad MW, Hemstreet G, Hersh EM, et al. Pharmacokinetics of recombinant interleukin 2 in humans. Cancer Res 1990; 50: 2009-2017.
11. Pozzilli P, Pozzilli C, Pantano P, Negri M, Andreani D, Cudworth AG. Tracking of indium-111-oxine labelled lymphocytes in autoimmune thyroid disease. Clin Endocrinol 1983; 19: 111-116.
12. Kaldany A, Hill T, Wentworth S, Brink J, D'Elia JA, Clouse M, Soeldner JS. Trapping of peripheral blood lymphocytes in the pancreas of patients with acute-onset insulin-dependent diabetes mellitus. Diabetes 1982; 31: 463-466.
13. Pipeleers D. Analysis of pancreata in recent onset type 1 diabetes: A survey. Diabetes Metabol Rev 1992; 7: 120-128.
14. Itoh N, Hanafusa T, Miyazaki A, et al. Mononuclear cell infiltration and its relation to the expression of major histocompatibility complex antigens and adhesion molecules in pancreas biopsy specimens from newly diagnosed insulin-dependent diabetes mellitus patients. J Clin Invest 1993; 92: 2313-2322.
15. Foulis AK, Liddle CN, Farquharson MA, Richmond JA, Weir RS. The histopathology of the pancreas in type 1 (insulin-dependent) diabetes mellitus: a 25-year review of deaths in patients under 20 years of age in the United Kingdom. Diabetologia 1986; 29: 267-274.
16. Hanafusa T, Miyazaki A, Miyagawa J, et al. Examination of islets in the pancreas biopsy specimens from newly diagnosed type 1 (insulin-dependent) diabetic patients. Diabetologia 1990; 33: 105-111.