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Volumn 1, Issue 1, 1996, Pages 3-11

Plasma resistance to activated protein C: An important link between venous thromboembolism and combined oral contraceptives - A short review

Author keywords

APC resistance; Cardiovascular disease; Combined oral contraceptives; Factor V Leiden; Thrombophilia

Indexed keywords

BLOOD CLOTTING FACTOR 5; BLOOD CLOTTING FACTOR 5 LEIDEN; ORAL CONTRACEPTIVE AGENT; PROTEIN C;

EID: 0030088870     PISSN: 13625187     EISSN: None     Source Type: Journal    
DOI: 10.3109/13625189609150650     Document Type: Review
Times cited : (13)

References (57)
  • 1
    • 0028314865 scopus 로고
    • Mutation in blood coagulation factor V associated with resistance to activated protein C
    • Bertina RM, Koeleman RPC, Koster T et al. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature (London) 1994; 369: 64-7
    • (1994) Nature (London) , vol.369 , pp. 64-67
    • Bertina, R.M.1    Koeleman, R.P.C.2    Koster, T.3
  • 2
    • 1542530102 scopus 로고    scopus 로고
    • Consensus Development Meeting 1995: Combined oral contraceptives and cardiovascular disease
    • The Consensus Committee. Consensus Development Meeting 1995: combined oral contraceptives and cardiovascular disease. Gynecol Endocrinol 1996; 10: 1-5
    • (1996) Gynecol Endocrinol , vol.10 , pp. 1-5
  • 3
    • 50549167392 scopus 로고
    • Pulmonary embolism
    • Jordan MV. Pulmonary embolism. Lancet 1961; 2: 1146-7
    • (1961) Lancet , vol.2 , pp. 1146-1147
    • Jordan, M.V.1
  • 4
    • 0025372083 scopus 로고
    • The Consensus Development Meeting: Metabolic aspects of oral contraceptives of relevance for cardiovascular disease
    • The Consensus Development Meeting: Metabolic aspects of oral contraceptives of relevance for cardiovascular disease. Am J Obstet Gynecol 1990; 162: 1335-7
    • (1990) Am J Obstet Gynecol , vol.162 , pp. 1335-1337
  • 5
    • 0006076678 scopus 로고
    • The epidemiology of venous thrombosis
    • Colman RW, Hirsh J, Marder VJ, Salzman EW, eds. Philadelphia: JB Lippincott
    • Carter C, Gent M. The epidemiology of venous thrombosis. In Colman RW, Hirsh J, Marder VJ, Salzman EW, eds. Hemostasis and Thrombosis. Philadelphia: JB Lippincott, 1982: 805-19
    • (1982) Hemostasis and Thrombosis , pp. 805-819
    • Carter, C.1    Gent, M.2
  • 6
    • 0024599768 scopus 로고
    • Risk factors for acute myocardial infarction in women: Evidence from the Royal College of General Practitioners' Oral Contraception Study
    • Croft P, Hannaford PC. Risk factors for acute myocardial infarction in women: evidence from the Royal College of General Practitioners' Oral Contraception Study. Br Med J 1989; 298: 165-8
    • (1989) Br Med J , vol.298 , pp. 165-168
    • Croft, P.1    Hannaford, P.C.2
  • 7
    • 0027100468 scopus 로고
    • Oral contraceptive use and cardiovascular disease: Is the relationship real or due to study bias?
    • Katerdahl DA, Realini JP, Cohen PA. Oral contraceptive use and cardiovascular disease: is the relationship real or due to study bias? J Fam Pract 1992; 35: 147-57
    • (1992) J Fam Pract , vol.35 , pp. 147-157
    • Katerdahl, D.A.1    Realini, J.P.2    Cohen, P.A.3
  • 8
    • 0028029477 scopus 로고
    • Increased risk of venous thrombosis in oral contraceptive users who are carriers of factor V Leiden mutation
    • Vandenbroucke JP, Koster T, Briët E, et al. Increased risk of venous thrombosis in oral contraceptive users who are carriers of factor V Leiden mutation. Lancet 1994; 344: 1453-7
    • (1994) Lancet , vol.344 , pp. 1453-1457
    • Vandenbroucke, J.P.1    Koster, T.2    Briët, E.3
  • 9
    • 0026558766 scopus 로고
    • Risk factors for fatal venous thromboembolism in young women; a case-control study
    • Thorogood M, Mann J, Murphy M, et al. Risk factors for fatal venous thromboembolism in young women; a case-control study. Int J Epidemiol 1992; 21: 48-52
    • (1992) Int J Epidemiol , vol.21 , pp. 48-52
    • Thorogood, M.1    Mann, J.2    Murphy, M.3
  • 10
    • 0029032629 scopus 로고
    • The risk of venous thromboembolism associated with low oestrogen oral contraceptives
    • Farmer RT, Preston TD. The risk of venous thromboembolism associated with low oestrogen oral contraceptives. J Obstet Gynaecol 1995; 15: 195-200
    • (1995) J Obstet Gynaecol , vol.15 , pp. 195-200
    • Farmer, R.T.1    Preston, T.D.2
  • 11
    • 0029564931 scopus 로고
    • Venous thromboembolic disease and combined oral contraceptives: Results of international multicentre case-control study
    • World Health Organization Collaborative Study of Cardiovascular Disease and Steroid Hormone Contraception. Venous thromboembolic disease and combined oral contraceptives: results of international multicentre case-control study. Lancet 1995; 346: 1575-82
    • (1995) Lancet , vol.346 , pp. 1575-1582
  • 12
    • 13344260005 scopus 로고
    • Effect of different progestagens in low oestrogen oral contraceptives on venous thromboembolic disease
    • World Health Organization Collaborative Study of Cardiovascular Disease and Steroid Hormone Contraception. Effect of different progestagens in low oestrogen oral contraceptives on venous thromboembolic disease. Lancet 1995; 346: 1582-8
    • (1995) Lancet , vol.346 , pp. 1582-1588
  • 13
    • 0029586002 scopus 로고
    • Risk of idiopathic cardiovascular death and non-fatal venous thromboembolism in women using oral contraceptives with differing progestagen components
    • Jick H, Jick SS, Gurewich V, et al. Risk of idiopathic cardiovascular death and non-fatal venous thromboembolism in women using oral contraceptives with differing progestagen components. Lancet 1995; 346: 1589-93
    • (1995) Lancet , vol.346 , pp. 1589-1593
    • Jick, H.1    Jick, S.S.2    Gurewich, V.3
  • 14
    • 0029609256 scopus 로고
    • Enhancement by factor V Leiden mutation of risk of deep-vein thrombosis associated with oral contraceptives containing third-generation progestagen
    • Bloemenkamp KWM, Rosendaal FR, Helmerhorst FM, et al. Enhancement by factor V Leiden mutation of risk of deep-vein thrombosis associated with oral contraceptives containing third-generation progestagen. Lancet 1995; 346: 1593-6
    • (1995) Lancet , vol.346 , pp. 1593-1596
    • Bloemenkamp, K.W.M.1    Rosendaal, F.R.2    Helmerhorst, F.M.3
  • 15
    • 0029671042 scopus 로고    scopus 로고
    • Third generation oral contraceptives and risk of venous thromboembolic disorders: An international case-control study
    • Spitzer WO, Lewis MA, Heinemann LA, et al. on behalf of Transnational Research Group on Oral Contraceptives and the Health of Young Women. Third generation oral contraceptives and risk of venous thromboembolic disorders: an international case-control study. Br Med J 1996; 312: 83-8
    • (1996) Br Med J , vol.312 , pp. 83-88
    • Spitzer, W.O.1    Lewis, M.A.2    Heinemann, L.A.3
  • 16
    • 0002961445 scopus 로고    scopus 로고
    • Evidence that currently available pills are associated with vascular disease: Venous disease
    • Hannaford, P.C. and Webb, A.M.C. (Carnforth, UK: Parthenon Publishing)
    • Bloemenkamp KWM, Rosendaal FR, Helmerhorst FM, et al. Evidence that currently available pills are associated with vascular disease: venous disease. In Hannaford, P.C. and Webb, A.M.C. Evidence-guided Prescribing of the Pill, pp. 61-76. (Carnforth, UK: Parthenon Publishing)
    • Evidence-guided Prescribing of the Pill , pp. 61-76
    • Bloemenkamp, K.W.M.1    Rosendaal, F.R.2    Helmerhorst, F.M.3
  • 17
    • 0023872729 scopus 로고
    • Pathophysiology and clinical aspects of fibrinolysis and inhibition of coagulation. Experimental and clinical studies with special reference to women on oral contraceptives and selected groups of thrombosis prone patients
    • Jespersen J. Pathophysiology and clinical aspects of fibrinolysis and inhibition of coagulation. Experimental and clinical studies with special reference to women on oral contraceptives and selected groups of thrombosis prone patients. Dan Med Bull 1988; 35: 1-33
    • (1988) Dan Med Bull , vol.35 , pp. 1-33
    • Jespersen, J.1
  • 18
    • 0025456595 scopus 로고
    • First European Esbjerg Conference on Sex Steroids and Metabolism. Oral contraceptives in the nineties: Metabolic aspects - Facts and fiction
    • First European Esbjerg Conference on Sex Steroids and Metabolism. Oral contraceptives in the nineties: metabolic aspects - facts and fiction. Am J Obstet Gynecol 1990; 163 (Suppl 2): 273-446
    • (1990) Am J Obstet Gynecol , vol.163 , Issue.2 SUPPL. , pp. 273-446
  • 19
    • 1842625488 scopus 로고    scopus 로고
    • Second European Esbjerg Conference on Sex Steroids and Metabolism. Oral contraceptives and cardiovascular disease - From myth to realities
    • Second European Esbjerg Conference on Sex Steroids and Metabolism. Oral contraceptives and cardiovascular disease - from myth to realities. Gynecol Endocrinol 1996; 10 (Suppl. 2)
    • (1996) Gynecol Endocrinol , vol.10 , Issue.2 SUPPL.
  • 20
    • 0029918525 scopus 로고    scopus 로고
    • Increased fibrin formation in blood in women above the age of 30 who are both oral contraceptive users and smokers
    • Jespersen J, Gram J. Increased fibrin formation in blood in women above the age of 30 who are both oral contraceptive users and smokers. Fibrinolysis 1996; 10: 9-13
    • (1996) Fibrinolysis , vol.10 , pp. 9-13
    • Jespersen, J.1    Gram, J.2
  • 21
    • 49749164627 scopus 로고
    • The biological significance of fibrinolysis
    • Astrup T. The biological significance of fibrinolysis. Lancet 1956; 2: 565-8
    • (1956) Lancet , vol.2 , pp. 565-568
    • Astrup, T.1
  • 22
    • 0000826288 scopus 로고
    • The haemostatic balance
    • Astrup T. The haemostatic balance. Thromb Diath Haemorrh 1958; 2: 347-57
    • (1958) Thromb Diath Haemorrh , vol.2 , pp. 347-357
    • Astrup, T.1
  • 23
    • 0025006373 scopus 로고
    • Disorders of the hemostatic system and the risk of the development of thrombotic and cardiovascular diseases: Limitations of laboratory diagnosis
    • Kluft C. Disorders of the hemostatic system and the risk of the development of thrombotic and cardiovascular diseases: limitations of laboratory diagnosis. Am J Obstet Gynecol 1990; 163: 305-12
    • (1990) Am J Obstet Gynecol , vol.163 , pp. 305-312
    • Kluft, C.1
  • 24
    • 0020659640 scopus 로고
    • Thrombin and plasmin activity and platelet activation in the development of venous thrombosis
    • Owen J, Kvam D, Nossel HL, et al. Thrombin and plasmin activity and platelet activation in the development of venous thrombosis. Blood 1983; 61: 476-82
    • (1983) Blood , vol.61 , pp. 476-482
    • Owen, J.1    Kvam, D.2    Nossel, H.L.3
  • 25
    • 0027461705 scopus 로고
    • Effects of monophasic low-dose oral contraceptives on fibrin formation and resolution in young women
    • Petersen KR, Sidelmann J, Skouby SO, et al. Effects of monophasic low-dose oral contraceptives on fibrin formation and resolution in young women. Am J Obstet Gynecol 1993; 168: 32-8
    • (1993) Am J Obstet Gynecol , vol.168 , pp. 32-38
    • Petersen, K.R.1    Sidelmann, J.2    Skouby, S.O.3
  • 26
    • 0025006379 scopus 로고
    • Enhanced generation and resolution of fibrin in women above the age of 30 years using oral contraceptives low in estrogen
    • Gram J, Munkvad S, Jespersen J. Enhanced generation and resolution of fibrin in women above the age of 30 years using oral contraceptives low in estrogen. Am J Obstet Gynecol 1990; 163: 438-42
    • (1990) Am J Obstet Gynecol , vol.163 , pp. 438-442
    • Gram, J.1    Munkvad, S.2    Jespersen, J.3
  • 27
    • 0027937293 scopus 로고
    • Effects of contraceptive steroids on cardiovascular risk factors in women with insulin-dependent diabetes mellitus
    • Petersen KR, Skouby SO, Sidelmann J, et al. Effects of contraceptive steroids on cardiovascular risk factors in women with insulin-dependent diabetes mellitus. Am J Obstet Gynecol 1994; 171: 400-5
    • (1994) Am J Obstet Gynecol , vol.171 , pp. 400-405
    • Petersen, K.R.1    Skouby, S.O.2    Sidelmann, J.3
  • 28
    • 0027942075 scopus 로고
    • Assessment of endothelial function during oral contraception in women with insulin-dependent diabetes mellitus
    • Petersen KR, Skouby SO, Sidelmann J, et al. Assessment of endothelial function during oral contraception in women with insulin-dependent diabetes mellitus. Metabolism 1994; 43: 1379-83
    • (1994) Metabolism , vol.43 , pp. 1379-1383
    • Petersen, K.R.1    Skouby, S.O.2    Sidelmann, J.3
  • 29
    • 0021857468 scopus 로고
    • a activity in the blood of asymptomatic patients with congenital antithrombin deficiency
    • a activity in the blood of asymptomatic patients with congenital antithrombin deficiency. J Clin Invest 1985; 76: 826-36
    • (1985) J Clin Invest , vol.76 , pp. 826-836
    • Bauer, K.A.1    Goodman, T.L.2    Kass, B.L.3
  • 30
    • 0024993079 scopus 로고
    • Guidelines on the investigation and management of thrombophilia. The British Committee for Standards in Haematology
    • Guidelines on the investigation and management of thrombophilia. The British Committee for Standards in Haematology. J Clin Pathol 1990; 43: 703-9
    • (1990) J Clin Pathol , vol.43 , pp. 703-709
  • 31
    • 0001627642 scopus 로고
    • Inherited antithrombin deficiency causing thrombophilia
    • Egeberg O. Inherited antithrombin deficiency causing thrombophilia. Thromb Diath Haemorrh 1965; 13: 516-30
    • (1965) Thromb Diath Haemorrh , vol.13 , pp. 516-530
    • Egeberg, O.1
  • 32
    • 0019789514 scopus 로고
    • Deficiency of protein C in congenital thrombotic disease
    • Griffin JH, Evatt B, Zimmerman TS, et al. Deficiency of protein C in congenital thrombotic disease. J Clin Invest 1981; 68: 1370-3
    • (1981) J Clin Invest , vol.68 , pp. 1370-1373
    • Griffin, J.H.1    Evatt, B.2    Zimmerman, T.S.3
  • 33
    • 0021720421 scopus 로고
    • Recurrent venous thromboembolism in patients with a partial deficiency of protein S
    • Comp PC, Esmon CT. Recurrent venous thromboembolism in patients with a partial deficiency of protein S. N Engl J Med 1984; 311: 1525-8
    • (1984) N Engl J Med , vol.311 , pp. 1525-1528
    • Comp, P.C.1    Esmon, C.T.2
  • 34
    • 0021873383 scopus 로고
    • Hereditary protein S deficiency and venous thromboembolism. A study in three Dutch families
    • Broekmans AW, Bertina RM, Reinalda-Poot J, et al. Hereditary protein S deficiency and venous thromboembolism. A study in three Dutch families. Thromb Haemost 1985; 53: 273-7
    • (1985) Thromb Haemost , vol.53 , pp. 273-277
    • Broekmans, A.W.1    Bertina, R.M.2    Reinalda-Poot, J.3
  • 36
    • 0023818347 scopus 로고
    • The frequency of type 1 heterozygous protein S and protein C deficiency in 141 unrelated young patients with venous thrombosis
    • Gladson CL, Scharrer I, Hach V, et al. The frequency of type 1 heterozygous protein S and protein C deficiency in 141 unrelated young patients with venous thrombosis. Thromb Haemost 1988; 59: 18-22
    • (1988) Thromb Haemost , vol.59 , pp. 18-22
    • Gladson, C.L.1    Scharrer, I.2    Hach, V.3
  • 37
    • 0025241268 scopus 로고
    • Deficiencies of coagulation inhibiting and fibrinolytic proteins in out-patients with deep-vein thrombosis
    • Heijboer H, Brandjes DPM, Büller HR, et al. Deficiencies of coagulation inhibiting and fibrinolytic proteins in out-patients with deep-vein thrombosis. N Engl J Med 1990; 323: 1512-16
    • (1990) N Engl J Med , vol.323 , pp. 1512-1516
    • Heijboer, H.1    Brandjes, D.P.M.2    Büller, H.R.3
  • 38
    • 0026465569 scopus 로고
    • Hereditary deficiency of antithrombin III, protein C and protein S: Prevalence in patients with a history of venous thrombosis and criteria for rational patient screening
    • Pabinger I, Brücker S, Kyrle PA, et al. Hereditary deficiency of antithrombin III, protein C and protein S: prevalence in patients with a history of venous thrombosis and criteria for rational patient screening. Blood Coagul Fibrinol 1992; 3: 547-53
    • (1992) Blood Coagul Fibrinol , vol.3 , pp. 547-553
    • Pabinger, I.1    Brücker, S.2    Kyrle, P.A.3
  • 39
    • 0027965649 scopus 로고
    • Physiological anticoagulation. Resistance to activated protein C and venous thromboembolism
    • Dahlbäck B. Physiological anticoagulation. Resistance to activated protein C and venous thromboembolism. J Clin Invest 1994; 94: 923-7
    • (1994) J Clin Invest , vol.94 , pp. 923-927
    • Dahlbäck, B.1
  • 40
    • 0028810738 scopus 로고
    • World distribution of factor V Leiden
    • Rees DC, Cox M, Clegg JB. World distribution of factor V Leiden. Lancet 1995; 346: 1133-4
    • (1995) Lancet , vol.346 , pp. 1133-1134
    • Rees, D.C.1    Cox, M.2    Clegg, J.B.3
  • 41
    • 0030031847 scopus 로고    scopus 로고
    • Absence of factor V Leiden mutation in Eskimos (Inuit)
    • de Maat MPM, Jespersen J, Kluft C, et al. Absence of factor V Leiden mutation in Eskimos (Inuit). Lancet 1996; 347: 58-9
    • (1996) Lancet , vol.347 , pp. 58-59
    • De Maat, M.P.M.1    Jespersen, J.2    Kluft, C.3
  • 42
    • 0028365619 scopus 로고
    • Evaluation of activated protein C resistance in stored plasma
    • Rosendaal FR, Bertina RM, Reitsma PH. Evaluation of activated protein C resistance in stored plasma. Lancet 1994; 343: 1289-90
    • (1994) Lancet , vol.343 , pp. 1289-1290
    • Rosendaal, F.R.1    Bertina, R.M.2    Reitsma, P.H.3
  • 43
    • 0028037137 scopus 로고
    • Identification of the same factor V gene mutation in 47 out of 50 thrombosis prone families with inherited resistance to activated protein C
    • Zöller B, Svensson PJ, He X, et al. Identification of the same factor V gene mutation in 47 out of 50 thrombosis prone families with inherited resistance to activated protein C. J Clin Invest 1994; 24: 2521-4
    • (1994) J Clin Invest , vol.24 , pp. 2521-2524
    • Zöller, B.1    Svensson, P.J.2    He, X.3
  • 44
    • 0029195229 scopus 로고
    • Influence of storage conditions on activated protein C resistance assay
    • Trossaërt M, Conard J, Horellou MH, et al. Influence of storage conditions on activated protein C resistance assay. Thromb Haemost 1995; 73: 162-6
    • (1995) Thromb Haemost , vol.73 , pp. 162-166
    • Trossaërt, M.1    Conard, J.2    Horellou, M.H.3
  • 45
    • 0029160116 scopus 로고
    • Influence of plasma platelets on activated protein C resistance assay
    • Sidelmann J, Gram J, Pedersen OD, et al. Influence of plasma platelets on activated protein C resistance assay. Thromb Haemost 1995; 74: 993-4
    • (1995) Thromb Haemost , vol.74 , pp. 993-994
    • Sidelmann, J.1    Gram, J.2    Pedersen, O.D.3
  • 46
    • 0029855649 scopus 로고    scopus 로고
    • Influence of blood handling on determination of plasma resistance against activated protein C
    • in press
    • Pedersen OD, Sidelmann J, Gram J, et al. Influence of blood handling on determination of plasma resistance against activated protein C. Fibrinolysis 1996; in press
    • (1996) Fibrinolysis
    • Pedersen, O.D.1    Sidelmann, J.2    Gram, J.3
  • 47
    • 0028651903 scopus 로고
    • Laboratory diagnosis of APC-resistance: A critical evaluation of the test and the development of diagnostic criteria
    • de Ronde H, Bertina R. Laboratory diagnosis of APC-resistance: a critical evaluation of the test and the development of diagnostic criteria. Thromb Haemost 1994; 72: 880-6
    • (1994) Thromb Haemost , vol.72 , pp. 880-886
    • De Ronde, H.1    Bertina, R.2
  • 48
    • 85046062198 scopus 로고
    • Resistance to activated protein is increased in women using oral contraceptives
    • Osterud B, Robertsen R, Asvang GB, et al. Resistance to activated protein is increased in women using oral contraceptives. Blood Coag Fibrinol 1994; 5: 853-4
    • (1994) Blood Coag Fibrinol , vol.5 , pp. 853-854
    • Osterud, B.1    Robertsen, R.2    Asvang, G.B.3
  • 49
    • 0028902902 scopus 로고
    • Sensitivity to activated protein C: Influence of oral contraceptives and sex
    • Henkens CMA, Bom VJJ, Seinen AJ, et al. Sensitivity to activated protein C: influence of oral contraceptives and sex. Thromb Haemost 1995; 73: 402-4
    • (1995) Thromb Haemost , vol.73 , pp. 402-404
    • Henkens, C.M.A.1    Bom, V.J.J.2    Seinen, A.J.3
  • 50
    • 26244433927 scopus 로고    scopus 로고
    • Oral contraceptives increase plasma resistance against activated protein C in women with insulin-dependent diabetes mellitus
    • Pedersen OD, Petersen KR, Skouby SO, et al. Oral contraceptives increase plasma resistance against activated protein C in women with insulin-dependent diabetes mellitus. Gynecol Endocrinol 1996; 10: 163-4
    • (1996) Gynecol Endocrinol , vol.10 , pp. 163-164
    • Pedersen, O.D.1    Petersen, K.R.2    Skouby, S.O.3
  • 51
    • 0029162113 scopus 로고
    • Resistance to activated protein C as a basis for venous thromboembolism associated with pregnancy and contraceptives
    • Hellgren M, Svensson PJ, Dahlbäck B. Resistance to activated protein C as a basis for venous thromboembolism associated with pregnancy and contraceptives. Am J Obstet Gynecol 1995; 173: 210-13
    • (1995) Am J Obstet Gynecol , vol.173 , pp. 210-213
    • Hellgren, M.1    Svensson, P.J.2    Dahlbäck, B.3
  • 52
    • 2442661554 scopus 로고
    • Factor V mutation, APC resistance and myocardial infarction in the Rotterdam Study
    • Bom van der JG, Kluft C, Bots ML, et al. Factor V mutation, APC resistance and myocardial infarction in the Rotterdam Study. Thromb Haemost 1995; 73: 1814
    • (1995) Thromb Haemost , vol.73 , pp. 1814
    • Bom Van Der, J.G.1    Kluft, C.2    Bots, M.L.3
  • 53
    • 0028931717 scopus 로고
    • High risk of thrombosis in patients homozygous for factor V Leiden (activated protein C resistance)
    • Rosendaal FR, Koster T, Vandenbroucke JP, et al. High risk of thrombosis in patients homozygous for factor V Leiden (activated protein C resistance). Blood 1995; 85: 1504-8
    • (1995) Blood , vol.85 , pp. 1504-1508
    • Rosendaal, F.R.1    Koster, T.2    Vandenbroucke, J.P.3
  • 54
    • 0023916301 scopus 로고
    • Is the activity of tissue plasminogen activator (t-PA) of clinical relevance in thrombophilia caused by protein S deficiency?
    • Gram J, Jespersen J, Bertina RM. Is the activity of tissue plasminogen activator (t-PA) of clinical relevance in thrombophilia caused by protein S deficiency? Fibrinolysis 1988; 2 (Suppl 2): 51-4
    • (1988) Fibrinolysis , vol.2 , Issue.2 SUPPL. , pp. 51-54
    • Gram, J.1    Jespersen, J.2    Bertina, R.M.3
  • 55
    • 0028000665 scopus 로고
    • APC-resistance as an additional risk factor for thrombosis in protein C deficient families
    • Koeleman BPC, Reitsma PH, Allaart CF, et al. APC-resistance as an additional risk factor for thrombosis in protein C deficient families. Blood 1994; 84: 1031-5
    • (1994) Blood , vol.84 , pp. 1031-1035
    • Koeleman, B.P.C.1    Reitsma, P.H.2    Allaart, C.F.3
  • 56
    • 0029016883 scopus 로고
    • Resistance to activated protein C as an additional genetic risk factor in hereditary deficiency of protein S
    • Zöller B, Berntsdotter A, Garcia de Frutos P, et al. Resistance to activated protein C as an additional genetic risk factor in hereditary deficiency of protein S. Blood 1995; 85: 3518-23
    • (1995) Blood , vol.85 , pp. 3518-3523
    • Zöller, B.1    Berntsdotter, A.2    Garcia De Frutos, P.3
  • 57
    • 0029924508 scopus 로고    scopus 로고
    • Oral contraceptives and screening for factor V Leiden
    • Rosendaal FR. Oral contraceptives and screening for factor V Leiden. Thromb Haemost 1996; 75: 524-5
    • (1996) Thromb Haemost , vol.75 , pp. 524-525
    • Rosendaal, F.R.1


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