A three-lever operant procedure differentiates the stimulus effects of R(-)-MDA from S(+)-MDA

Journal of Pharmacology and Experimental Therapeutics

Volumn 276, Issue 2, 1996, Pages 594-601

  Young, Richard ^a   Glennon, Richard A ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,5 DIMETHOXY 4 METHYLAMPHETAMINE; 3,4 METHYLENEDIOXYAMPHETAMINE; CENTRAL STIMULANT AGENT; PSYCHEDELIC AGENT;

ANIMAL; ARTICLE; DISCRIMINATION LEARNING; DRUG EFFECT; INSTRUMENTAL CONDITIONING; MALE; RAT; SPRAGUE DAWLEY RAT; STEREOISOMERISM;

2,5-DIMETHOXY-4-METHYLAMPHETAMINE; 3,4-METHYLENEDIOXYAMPHETAMINE; ANIMALS; CENTRAL NERVOUS SYSTEM STIMULANTS; CONDITIONING, OPERANT; DISCRIMINATION LEARNING; HALLUCINOGENS; MALE; RATS; RATS, SPRAGUE-DAWLEY; STEREOISOMERISM;

EID: 0030088033     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. BROADBENT, J., APPEL, J. B., MICHAEL, E. K. AND RICKER, J. H.: Discriminative stimulus effects of the optical isomers of 3,4-methylenedioxyamphetamine (MDA). Behav. Pharmacol. 3: 443-454, 1992.
2. BROADBENT, J., MICHAEL, E. K. AND APPEL, J. B.: Generalization of cocaine to the isomers of 3,4-methlenedioxyamphetamine and 3,4-methylenedioxymethamphetamine. Drug Dev. Res. 16:443-450, 1989.
3. CALLAHAN, P. M. AND APPEL, J. B. Differences in the stimulus properties of 3,4-methylendioxyamphetamine and 3,4-methylenedioxymethamphetamine in animals trained to discriminate hallucinogens from saline. J. Pharmacol. Exp. Ther. 246: 866-870, 1988.
4. COLPAERT, J. C., NIEMEGEER, C. J. E. AND JANSSEN, P. A. J.: A drug discrimination analysis of lysergic acid diethylamide (LSD): In vivo agonist and antagonist effects of purported 5-hydroxytryptamine antagonists and of pirenperone, a LSD antagonist. J. Pharmacol. Exp. Ther. 321: 206-214, 1982.
5. EVANS, S. M. AND JOHANSON, C. E.: Discriminative stimulus properties of 3,4-methylenedioxymethamphetamine and 3,4-methylenedioxyamphetamine in pigeons. Drug Alcohol Depend. 18: 159-164, 1986.
6. FINNEY, D. J : Statistical Methods in Biology Assay, 2nd ed., Hafner, New York, 1964.
7. GLENNON, R. A.: Stimulus properties of hallucinogenic phenalkylamines and related designer drugs: Formulation of structure activity relationships. In Pharmacology and toxicology of amphetamine and related designer drugs, ed by K. Ashgar and E. De Souza, pp. 43-67, NIDA Research Monograph 94, Washington, DC, U.S. Government Printing Office, 1989.
8. GLENNON, R. A. AND HAUCK, A. E.: Mechanistic studies on DOM as a discriminative stimulus. Pharmacol. Biochem. Behav. 23: 937-941, 1985.
9. GLENNON, R. A. AND YOUNG, R.: MDA: A psychoactive agent with dual stimulus effects. Life Sci 34: 379-383, 1984a.
10. GLENNON, R. A. AND YOUNG, R.: MDA: An agent that produces stimulus effects similar to those of 3,4 DMA, LSD and cocaine. Eur. J. Phamacol. 99: 249-250, 1984b.
11. GLENNON, R A. AND YOUNG, R.: Further investigation of the discriminative stimulus properties of MDA. Pharmacol. Biochem. Behav. 20: 501-505, 1984c.
12. GLENNON, R. A., ROSECRANS, J. A. AND YOUNG, R.: Drug-induced discrimination: A description of the paradigm and a review of its specific application to the study of hallucinogenic agents. Med. Res. Rev 3: 289-340, 1983a
13. GLENNON, R. A., YOUNG, R AND ROSECRANS, J. A.: Antagonism of the effects of the hallucinogen DOM and the purported 5-HT agonist quipazine by 5-HT2 antagonists. Eur. J. Pharmacol. 91: 189-196, 1983b.
14. GLENNON, R. A., YOUNG, R., ROSECRANS, J. A. AND ANDERSON, G. M.: Discriminative stimulus properties of MDA analogs. Biol. Psychiatry 17: 807-814, 1982.
15. HARTIG, P. R.: Molecular biology of 5-HT receptors. Trends Pharmacol. Sci. 10: 64-69, 1989.
16. ISMAIEL, A. M., DE Los ANGELES, J., TEITLER, M., INGHER, S. AND GLENNON, R. A.: Antagonism of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane stimulus with a newly identified 5-HT2- versus 5-HT1C-selective antagonist. J. Med. Chem. 36: 2519-2525, 1993.
17. KAMIEN, J. B., JOHANSON, C. E., SCHUSTER, C. R. AND WOOLVERTON, W. L.: The effects of (±) methylenedioxymethamphetamine and (±) methylenedioxyamphetamine in monkeys trained to discriminate (+) amphetamine from saline. Drug Alcohol Depend. 18: 139-147, 1986.
18. OBERLENDER, R. AND NICHOLS, D. E.: Drug discrimination studies with MDMA and amphetamine. Psychopharmacology 95: 71-76, 1988.
19. SCHREIBER, R., BROCCO, M. AND MILLAN, M. J.: Blockade of the discriminative stimulus effects of DOI by MDL 100,907 and the "atypical" antipsychotics, clozapine and risperidone. Eur. J. Pharmacol. 264: 99-102, 1994.
20. SHULGIN, A. T.: Psychotominetic drugs: Structure-activity relationships. In Handbook of Psychopharmacology, vol. 11, ed. by L. L. Iversen, S. D. Iversen and S. H. Snyder, p. 243, Plenum Press, New York, 1978.
21. SILVERMAN, P. B. AND Ho, B. T.: The discriminative stimulus properties of 2,5 dimethoxy-4-methylamphetamine (DOM): Differentiation from amphetamine. Psychopharmacology 68: 209-215, 1980.
22. TERRY, P., WITKIN, J. M. AND KATZ, J. L.: Pharmacological characterization of the novel discriminative stimulus effects of a low dose of cocaine. J. Pharmacol. Exp. Ther. 270: 1041-1048, 1994
23. TILSON, H. A., BAKER, T. G. AND GYLYS, J. A.: A comparison of the discriminative stimulus properties of R-2,5-dimethoxy-4-methylamphetamine (R-DOM) and S-amphetamine in the rat. Psychopharmacologia 44: 225-228, 1975.
24. WHITE, F. J. AND APPEL, J. B.: Training dose as a factor in LSD-saline discrimination. Psychopharmacolgy 76: 20-25, 1982.
25. YOUNG, R. AND GLENNON, R. A.: Discriminative stimulus properties of amphetamine and structurally related phenalkylamines. Med. Res. Rev. 6: 99-130, 1986.
26. YOUNG, R., GLENNON, R. A. AND ROSECRANS, J A.: Discriminative stimulus properties of the hallucinogenic agent DOM. Commun. Psychopharmacol. 4: 501-506, 1980.