Hydrolytic degradation of films prepared from blends of high and low molecular weight poly(DL-lactic acid)s

Journal of Biomedical Materials Research

Volumn 30, Issue 2, 1996, Pages 201-207

  Mauduit, Jacques ^a   Pérouse, Eric ^a   Vert, Michel ^b  

^a Laboratoires Perouse Implants   (France)

^b UNIV MONTPELLIER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCOMPATIBILITY; BIODEGRADATION; FILM PREPARATION; OLIGOMERS; ORGANIC ACIDS; POLYMER BLENDS; SIZE EXCLUSION CHROMATOGRAPHY;

ACID CATALYZED DEGRADATION; HYDROLYTIC DEGRADATION; POLYLACTIC ACIDS;

BIOFILMS;

ACETONE; OLIGOMER; POLYLACTIC ACID;

ARTICLE; BIODEGRADATION; ENZYME ASSAY; FILM; GAS CHROMATOGRAPHY; GEL PERMEATION CHROMATOGRAPHY; HYDROLYSIS; IN VITRO STUDY; MOLECULAR WEIGHT; PHYSICAL CHEMISTRY; POLYMERIZATION; WATER ABSORPTION;

ABSORPTION; ACETONE; CHEMISTRY, PHYSICAL; CHROMATOGRAPHY, GEL; HYDROLYSIS; LACTIC ACID; MEMBRANES, ARTIFICIAL; MOLECULAR WEIGHT; POLYMERS;

EID: 0030087773     PISSN: 00219304     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4636(199602)30:2<201::AID-JBM10>3.0.CO;2-P     Document Type: Article

References (11)

1. M. Vert, "Bioresorbable polymers for temporary therapeutic applications," Angew. Makromol. Chem., 166/167, 155-168 (1989).
2. D. H. Lewis, "Controlled-release of bioactive agents from lactide/glycolide polymers," Drugs Pharmacol. Sci., 45, 1-41 (1990).
3. M. Vert, P. Christel, F. Chabot, and J. Leray, "Bioresorbable plastic materials for bone surgery," in Macromolecular materials, G. W. Hastings and P. Ducheyne (eds.), CRC Press, Boca Raton, FL, 1984, pp. 119-142.
4. X. Zhang, M. F. A. Goosen, U. P. Wyss, and D. Pichora, "Biodegradable polymers for orthopedic applications," J.M.S. Rev. Macromol. Chem. Phys., C33(1), 81-102 (1993).
5. J. Mauduit, N. Bukh, and M. Vert, "Gentamycin/ poly(lactic acid) blends aimed at sustained release local antibiotic therapy administered per-operatively. III. The case of gentamycin sulfate in films prepared from high and low molecular weight poly(DL-lactic acids)," J. Controlled Release, 25, 43-49 (1993).
6. R. Bodmeier, K. H. Oh, and H. Chen, "The effect of the addition of low molecular weight poly(D,L-lactide) on drug release from biodegradable poly(D,L-lactide) drug delivery systems," Int. J. Pharmacol., 51, 1-8 (1989).
7. M. Vert, J. Mauduit, R. Frank, and P. Robert, French Pat. Application 92-06797 (1992).
8. P. Robert, "Recherches sur l'utilisation d'une membrane biorésorbable dans la régénération tissulaire guidée," Ph.D. thesis, University Louis Pasteur of Strasbourg I, France, 1994.
9. P. Robert, J. Mauduit, R. M. Frank, and M. Vert, "Biocompatibility and resorbability of a polylactic acid membrane for periodontal guided tissue regeneration," Biomaterials, 14, 353-358 (1993).
10. J. Mauduit, N. Bukh, and M. Vert, "Gentamycin/poly (lactic acid) blends aimed at sustained release local antibiotic therapy administered per-operatively. I. The case of gentamycin base and gentamycin sulfate in poly(DL-lactic acid) oligomers," J. Controlled Release, 23, 209-220 (1993).
11. C. G. Pitt, M. M. Gratzl, G. L. Kimmel, J. Surles, and A. Schindler, "Aliphatic polyesters. II. The degradation of poly(DL-lactide), poly(ε-caprolactone) and their copolymers in vivo," Biomaterials, 2, 215-220 (1981).