Effects of calcium antagonist diltiazem on leukocyte elastase and on reactive oxygen species production in human neutrophils

Pharmacological Research

Volumn 33, Issue 2, 1996, Pages 117-122

  Khalfi, F ^a   Gressier, B ^a   Brunet, C ^a   Dine, T ^a   Luyckx, M ^a   Cazin, M ^a   Cazin, J C ^a  

^a UNIV LILLE   (France)

Author keywords

Cytosolic calcium; Diltiazem; Elastase; Oxidants; PKC; PMNs

Indexed keywords

CALCIUM ANTAGONIST; CALCIUM IONOPHORE; DILTIAZEM; DIOCTANOIN; FORMYLMETHIONYLLEUCYLPHENYLALANINE; HYDROXYL RADICAL; HYPOCHLOROUS ACID; LEUKOCYTE ELASTASE; PHORBOL 13 ACETATE 12 MYRISTATE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; ZYMOSAN;

ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; ENZYME REGULATION; ENZYME RELEASE; HUMAN; HUMAN CELL; LEUKOCYTE ACTIVATION; NEUTROPHIL; NORMAL HUMAN; PRIORITY JOURNAL;

EID: 0030087544     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1006/phrs.1996.0017     Document Type: Article

References (33)

1. 1. Roos, D. The respiratory burst of phagocytic leucocytes. Drug Invest 1991; 3: 48-58.
2. 2. Weiss SJ, Klein R. Chlorination of taurine by human neutrophils. J Clin Invest 1982; 70: 598-607.
3. 3. Mitchinson, MJ, Ball, RY. Macrophages and atherogenesis. Lancet 1987; 18: 146-9.
4. 4. Fulop T Jr, Jacob MP. Effect of elastin peptides on human monocytes: Ca mobilization, stimulation of respiratory burst and enzyme secretion. Biol Biophys Res Commun 1986; 141: 92-8.
5. 5. Wallaert B, Gressier B, Aerts C, Mizon C, Voisin C, Mizon J. Oxidative inactivation of α1 proteinase inhibitor by alveolar macrophages from healthy smokers requires the presence of myeloperoxidase. Am J Respir Cell Mol Biol 1991; 5: 437-44.
6. 6. Lehr HA. Oxidized LDL-induced leukocyte/ endothelium: interaction in vivo involves the receptor for platelet-activating factor. Arterioscler Thromb 1993; 13: 1013-8.
7. 2 and superoxide anion production in rat peritoneal macrophages by the calcium antagonists Nifedipine and Nisoldipine. Arzneim-Forsch-Drug Res 1991; 41: 781-5.
8. 8. Cooke E, Hallett MB. The role of C-kinase in the physiological activation of the neutrophil oxidase. Biochem J 1985; 232: 323-7.
9. 9. Laurent F, Benoleil AM. Oxidative metabolism of polymorphonuclear leukocytes: modulation by adhesive stimuli. J Leuk Biol 1991; 49: 217-26.
10. 10. Nishizuka Y. Studies and perspectives of protein kinase-C. Science 1986; 233: 305-9.
11. 11. Tscharner Von V. Ion channels in human neutrophils activated by a rise in free cytosolic calcium concentration. Nature 1986; 324: 369-72.
12. 12. Kessels RGC, ROSS D, Verhoeven AJ. fMet-Leu-Phe-induced activation of phospholipase D in human neutrophils. J Biol Chem 1991; 266: 23152-6.
13. 13. Maridonneau-Parini I. Identification of distinct activation pathways of neutrophil NADPH-oxidase. J Immunol 1986; 137: 2925-9.
14. 14. Kawada M, Edashige K, Watanabe Y. Increase in cell responses and protein phosphorylation of neutrophils induced by synthetic diacylglycerols. Physiol Chem Phys 1993; 25: 237-52.
15. 15. Weisdorf DJ, Thayer MS. Occult intracellular calcium pools: relevance to neutrophil oxidant production. J Lab Clin Med 1989; 114: 260-5.
16. 16. Werner U, Seitz O, Szelenyi I. Stimulated elastase release from human leukocytes: Influence of anti-asthmatic, anti-inflammatory and calcium antagonist drugs in vitro. Agent-Action 1993; 38: C112-4.
17. 17. Karnad AB. Effect of nisoldipine on priming and activation of the human neutrophil respiratory burst. Agent Action 1990; 31: 79-85.
18. 18. Irita K, Fujita I. Calcium channel antagonist induced inhibition of superoxide production in human neutrophils. Biochem Pharmacol 1986; 35: 3455-71.
19. 19. Cabanis A, Gressier B, Lebegue S, Brunet C, Dine T, Luyckx M, Cazin M, Cazin JC. A rapid density gradient technique for separation of polymorphonuclear granulocytes. APMIS 1994; 102: 119-21.
20. 20. Cohen HJ, Chovaniec RE. Superoxide generation by digitonin stimulated guinea pig granulocytes. A basis for continuous assay for monitoring superoxide production and for the study of the activation of generation system. J Clin Invest 1978; 61: 1081-7.
21. 21. Weiss SJ, Klein R. Chlorination of taurine by human neutrophils. J Clin Invest 1982; 70: 598-607.
22. 22. Gressier B, Cabanis A, Lebegue S, Brunet C, Dine T, Luyckx M, Cazin M, Cazin JC. Decrease of hypochlorous acid and hydroxyl radical generated by stimulated human neutrophils: Comparison in vitro of some thiol-containing drugs. Meth Find Exp Clin Invest 1994; 16: 9-13.
23. 23. Aruoma OI, Halliwell B. The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide and hypochlorous acid. Free Radical Biol Med 1989; 6: 593-7.
24. 23. Halliwell, B. Superoxide dependent formation of hydroxyl radicals in the presence of iron chelates. Biomed Press FEBS Lett 1978; 92: 321-2.
25. 24. Boniface M, Cazin JC, Cazin M, Luyckx M. Calcul sur ordinateur de la dose efficace par la methode des probits. Application au calcul de la dose léthale 50. Bull Soc Chim 1972; 4: 187-95.
26. 25. Flaherty JT. Myocardial injury mediated by oxygen free radicals. Am J Med 1991; 91: 3C-7 9S-85S.
27. 26. Wallaert B, Gressier B, Marquette CH, Gosset P, Remy-Jardin M, Mizon J, Tonnel AB. Inactivation of α-1PI by alveolar inflammatory cells from smoking patients with or without emphysema. Am Rev Respir Dis 1993; 147: 1537-43.
28. 27. Wong K. Differential effect of diltiazem and TA-3090 on calcium homeostatis of neutrophils. Toxicol Appl Pharmacol 1991; 107: 514-25.
29. 28. Jacob MP, Moura AM, Tixier JM. Prevention by calcitonin of the pathological modifications of the rabbit arterial wall induced by immunization with elastin peptides: effect on vascular smooth muscle permeability to ions. Exp Mol Pathol 1987; 46: 345-56.
30. 29. Long MM, King VJ. Elastin peptides as chemoattractants for bovine aortic endothelial cells. J Cell Physiol 1989; 140: 512-8.
31. 30. Nilsson J, Sjolund M. The calcium antagonist nifedipine inhibits arterial smooth muscle proliferation. Atherosclerosis 1985; 58: 109-22.
32. 31. Metha J, Metha P. Effects of verapamil on platelet aggregation, ATP release and thromboxane generation. Thromb Res 1983; 30: 469-75.
33. 32. Schneider W., Kober G. Retardation of development and progression of coronary atherosclerosis: a new indication for calcium antagonists? Eur J Clin Pharmacol 1990; 39: S17-23.