Genotoxic and mutagenic effects of antitumor anthracyclines and aglycones: studies with two test systems

Genetika

Volumn 32, Issue 2, 1996, Pages 233-239

  Vasil'Eva, S V ^a,b   Makhova, E V ^a,b   Efremenkova, O V ^a,b   Bartoshevich, Yu E ^a,b  

^a SEMENOV INSTITUTE OF CHEMICAL PHYSICS   (Russian Federation)

^b Department of Medicinal Chemistry   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

ACLARUBICIN; AKLAVINONE; ANTINEOPLASTIC ANTIBIOTIC; CARUBICIN; DAUNORUBICIN; DOXORUBICIN; INTERCALATING AGENT; MUTAGENIC AGENT; NAPHTHACENE DERIVATIVE;

ARTICLE; CONFORMATION; DNA REPAIR; DRUG EFFECT; GENETICS; MUTAGEN TESTING; SALMONELLA TYPHIMURIUM; STRUCTURE ACTIVITY RELATION;

ACLARUBICIN; ANTIBIOTICS, ANTINEOPLASTIC; CARUBICIN; DAUNORUBICIN; DOXORUBICIN; INTERCALATING AGENTS; MUTAGENICITY TESTS; MUTAGENS; NAPHTHACENES; NUCLEIC ACID CONFORMATION; SALMONELLA TYPHIMURIUM; SOS RESPONSE (GENETICS); STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0030078620     PISSN: 00166758     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Schwartz H.S., Kanter P.M. DNA-related actions of adriamycin, daunorubicin and some derivatives in human leucemia cells // Anthracyclines / Eds Crooke ST., Reich S.D. N.Y.; L.: Acad. Press, 1980. P. 43 - 59.
2. Chuang RY., Chuang L.F. Inhibition of chicken myeloblastosis RNA polymerase II activity by adriamycin // Biochemistry. 1979. V. 18. P. 2069 - 2073.
3. Bachur N.R. Adriamycin (NSC-123127) pharmacology // Cancer Chemother. Rep. 1975. V. 3. P. 153 - 158.
4. Pristos C.H., Key es S.R., Sartorelli A.C. Effect of the superoxide dismutase inhibitor, diethyldithiocarbamate, on the cytotoxicity of mitomycin antibiotics // Cancer. Biochem. Biophys. 1989. V. 10. P. 289 - 298.
5. Kaasch M., Kaasch J., Quinones A. Expression of the dna N and dna Q genes of Escherichia coli is inducible by mitomycin C // Mol. Gen. Genet. 1989. V. 219. P. 187 - 192.
6. Kumaresan K.R.,Jayaraman R. The sir locus of Escherichia coli: a gene involved in SOS-independent repair of mitomycin C -induced DNA damage // Mutât. Res. 1990. V. 235. P. 85 - 92.
7. Acton EM. N-alkylation of anthracyclines // Anthracyclines / Eds Crooke S.T., Reich S.D. N.Y.; L.: Acad. Press, 1980. P. 15-25.
8. McCann J., Chio E., Yamasaki E., Ames B.N. Detection of carcinogens as mutagens in the Salmonella microsome test: assay of 300 chemicals // Proc. Natl. Acad. Sci. U.S.A. 1975. V. 72. P. 5135 - 5139.
9. Ohta T., Nakamura N., Moriya M. et al. The SOS function inducing activity of chemical mutagens in Escherichia coli II Mutât. Res. 1984. V. 131. P. 101 - 109.
10. Quillardet P., De Bellecombe C., Hofnung M. The SOS chromotest, a colorimetric bacterial assay for genotoxins: validation study with 83 compounds // Mutât. Res. 1985. V. 147. P. 79 - 95.
11. Myers C.E. Antitumor antibiotics. I. Antracyclines / Ed. Pinedo E.V. Amsterdam: Excepta Medica, 1979. P. 56 - 74.
12. Quillardet P., Huisman O., D'Ari R.D., Hofnung M. SOS-chromotest, a direct assay of induction of an SOS function in Escherichia coli K-12 to measure genotoxicity // Proc. Natl. Acad. Sci. U.S.A. 1982. V. 79. P. 5971-5975.
13. Vasilieva S., Tanirbergenov B., Abilev S. et al. A comparative study of mutagenic and SOS-inducing activity of biphenyls, phenanthrenequinones and fluorenones // Mutât. Res. 1990. V. 244. P. 321 - 329.
14. Hartman P.E., Ames B.N., Roth J.R. et al. Target sequences for mutagenesis in Salmonella histidine-requiring mutants // Environ Mutagen. 1986. V. 8. P. 631 - 641.
15. Mori S., Ogasawara T., Nishimura M. et al. Physicochemical properties and stability of aclacinomycin A hydrochloride//Jap. J. Antib. 1980. V. 33. N5. P. 618 - 623.
16. Haworth S., Lawlor T., Mortelmans K. et al. Salmonella mutagenicity results for 250 chemicals // Environ. Mutagen. 1983. V. 5. Suppl. 1. P. 3 - 142.
17. Quillardet P., Tonati E., Hofnung M. First characterization of the mutagenic spesificity of 7-methoxy-2-nitronaphto-2,1-b 1 furan (R7000) in Salmonella typhimurim//Mutât. Res. 1981. V. 248. P. 85 - 92.
18. Perry K.L.,ElU'de S.J.. MitchelB.B. et at. Umu DC and Muc AB opérons whose products are required for UV light and chemical-induced mutagenesis; UmuD; MucA and LexA protein share homology // Proc. Natl. Acad. Sci. U.S.A. 1985. V. 82. P. 4331 - 4335.
19. Smith CM., Eisenstadt P. Identification of a umuDC locus in Salmonella t\phimurium LT2 //J. Bacteriol. 1989. V. 171. P. 3860-3865.
20. Power E.G.M., Phillips I. Induction of gene (umuC) by 4-quinolone antibacterial drugs // Mol. Microbiol. 1982. V. 36. P. 78 - 82.
21. Mamher S.W., Okasinski W.G., Pinter C.D., Tunac J.B. The Escherichia coli K-12 SOS chromotest agar spot test for simple, rapid detection of genotoxic agents // Mutât. Res. 1986. V. 171. P. 83 - 90.
22. McDanicls A.E., Reycs A.L. WymerL.J. et al. Comparison of the Salmonella (Ames) test, Umu tests, and the SOS chromotest for detecting genotoxins // Environ. Mol. Mutagen. 1990. V. 16. P. 204 - 215.
23. Muller J., Jam S. Assesment of oxidative DNA damage in the oxy R-deficient SOS chromotest strain Escherichia coli PQ300 // Environ. Mol. Mutagen. 1992. V. 20. P. 297 - 306.
24. Walker G.C. Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli II Microbiol. ReV. 1984. V. 48. P. 60 - 93.
25. Zeiger E., Anderson B., Haworth S. et al. Salmonella mutagenicity tests. V. Results from the testing of 311 chemicals // Environ. Mol. Mutagen. 1992. V. 19. Suppl. 21. P. 2- 141.