Solution conformation by NMR and molecular modeling of three sulfide-free somatostatin octapeptide analogs compared to angiopeptin

Journal of Computer-Aided Molecular Design

Volumn 10, Issue 1, 1996, Pages 83-86

  Hennig, Philippe ^a   Raimbaud, Eric ^a   Thurieau, Christophe ^a   Volland, Jean Paul ^a   Michel, André ^a   Fauchère, Jean Luc ^a  

^a INSTITUT DE RECHERCHES SERVIER   (France)

Author keywords

Angiopeptin; Cyclic peptide; Peptide molecular modeling; Peptide NMR; Peptide pharmacophore; Restenosis; Somatostatin

Indexed keywords

DISEASES; HYDROGEN BONDS; MOLECULAR MODELING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHARMACODYNAMICS; SULFUR COMPOUNDS;

ANGIOPEPTIN; CYCLIC PEPTIDES; OCTAPEPTIDE; PEPTIDE MOLECULAR MODELING; PEPTIDE NMR; PEPTIDE PHARMACOPHORE; PHARMACOPHORES; RESTENOSIS; SOLUTION CONFORMATIONS; SOMATOSTATIN;

PEPTIDES;

ANGIOPEPTIN; CARDIOVASCULAR AGENT; DRUG DERIVATIVE; OLIGOPEPTIDE; SOMATOSTATIN;

AMINO ACID SEQUENCE; ANIMAL; AORTA VALVE STENOSIS; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; COMPUTER SIMULATION; MOLECULAR GENETICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN CONFORMATION; RAT; SOLUTION AND SOLUBILITY;

AMINO ACID SEQUENCE; ANIMALS; AORTIC VALVE STENOSIS; CARDIOVASCULAR AGENTS; COMPUTER SIMULATION; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; OLIGOPEPTIDES; PROTEIN CONFORMATION; RATS; SOLUTIONS; SOMATOSTATIN;

EID: 0030077942     PISSN: 0920654X     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00124468     Document Type: Article

References (16)

1. Coy, D.H., Heiman, M.L. and Rossowski, X, In Marshall, G.R. (Ed.) Peptides: Chemistry and Biology (Proceedings of the 10th American Peptide Symposium) , ESCOM, Leiden, 1988, pp. 462463.
2. Annu. Drug Data Rep., 15 (1993) 1070 and references cited therein.
3. Lundergan, C., Foegh, M.L., Vargas, S., Eufemio, M., Bormes, G.W., Kot, P.A. and Ramwell, P.W., Atherosclerosis, 80 (1989) 49.
4. Conte, J.V., Foegh, M.L., Calcagno, D., Wallace, R.B. and Ramwell, P.W., Transplant. Proc., 21 (1989) 3686.
5. Santoian, E.G., Schneider, J.E., Gravanis, M.B., Foegh, M., Tarazona, N., Cipolla, G.D. and King III, S.B., Circulation, 88 (1993) 11.
6. Thurieau, C., Janiak, P., Krantic, S., Guyard, C.,Pillon, A., Kucharczyk, N., Vilaine, J.P. and Fauchere, J.L., Eur. J. Med. Chem., 30(1995) 115.
7. Neidig, K.-P., Geyer, M., Görler, A., Antz, C., Saffrich, R., Beneicke, W. and Kalbitzer, H.R., J Biomol. NMR, 6 (1995) 255.
8. Wuthrich, K. (Ed.) NMR of Proteins and Nucleic Acids, Wiley, New York, NY, 1986.
9. Bystrov, V.K., Prog. NMR Spectrosc., 10 (1976) 41.
10. De Marco, A. and Wuthrich, K., J. Magn. Reson., 24 (1976) 201.
11. SYBYL (with modules Sybylbasic and Biopolymer) , v. 6.1a, Tripos Associates, St. Louis, MO.
12. Powell, M.J.D., Math. Programming, 12 (1977) 241.
13. Clark, M., Cramer III, R.D. and Van Opdenbosch, N., J. Cornput. Chem., 10 (1989) 982.
14. Gasteiger, J. and Marsili, M., Tetrahedron, 36 (1980) 3219.
15. Weiner, S.J., Kollman, P.A., Case, D.A., Singh, U.C., Ghio, C., Alagona, G., Profeta, S. and Weiner, P., J. Am. Chem. Soc., 106 (1984) 765.
16. Van Binst, G. and Tourwé, D., Pept. Res., 5 (1992) 8.