Expression of urokinase-type plasminogen activator, its receptor, and its inhibitor in gastric adenocarcinoma tissues

Journal of Korean Medical Science

Volumn 11, Issue 1, 1996, Pages 33-37

  Hong, Seok Il ^a   Park, In Chul ^a   Son, Young Sook ^a   Lee, Seung Hoon ^a   Kim, Byoung Gie ^a   Lee, Jong Inn ^a   Lee, Tai Won ^a   Kook, Yoon Hoh ^b   Min, Young Il ^c   Hong, Weon Seon ^c  

^a Korea Cancer Center Hospital   (South Korea)

^b Seoul National University   (South Korea)

^c University of Ulsan College of Medicine   (South Korea)

Author keywords

Gastric adenocarcinoma; Immunohistochemistry; Metastatic lymph node; Northern blot analysis; Plasminogen activator inhibitor 1; Plasminogen activator receptor; Urokinase type plasminogen activator

Indexed keywords

CELL SURFACE RECEPTOR; MESSENGER RNA; PLASMINOGEN ACTIVATOR; PLASMINOGEN ACTIVATOR INHIBITOR 1; PLASMINOGEN ACTIVATOR, UROKINASE RECEPTORS; UROKINASE;

ADENOCARCINOMA; ARTICLE; BIOSYNTHESIS; ENZYME IMMUNOASSAY; GENE EXPRESSION; GENETICS; HUMAN; LYMPH NODE; METABOLISM; METASTASIS; PATHOLOGY; STOMACH MUCOSA; STOMACH TUMOR;

ADENOCARCINOMA; GASTRIC MUCOSA; GENE EXPRESSION; HUMANS; IMMUNOENZYME TECHNIQUES; LYMPH NODES; NEOPLASM METASTASIS; PLASMINOGEN ACTIVATOR INHIBITOR 1; PLASMINOGEN ACTIVATORS; RECEPTORS, CELL SURFACE; RNA, MESSENGER; STOMACH NEOPLASMS; URINARY PLASMINOGEN ACTIVATOR;

EID: 0030077306     PISSN: 10118934     EISSN: None     Source Type: Journal    
DOI: 10.3346/jkms.1996.11.1.33     Document Type: Article

References (27)

1. Andreasen PA, Georg B, Lund LR, Riccio A, Stracey SN. Plasminogen activator inhibitors : hormonally regulated serpins. Mol Cell Endocrinol 1990; 68 : 1-19.
2. Blasi F. Urokinase and urokinase receptor: a parcrine/autocrine system regulating cell migration and invasiveness. Bioassays 1993; 15 : 105-11.
3. Collen D, Lijnen HR. The fibrolytic system of man. In: David S, ed. CRC Critical Reviews in Onclogy/Heamatology. Boca Raton:FL CRC Press, 1986; 249-301.
4. Danø K, Asdreasen PA, Grøndahl-Hansen J, Kriatensen P, Nielsen LS, Skriver L. Plasminogen activators, tissue degradation, and cancer.Adv Cancer Res 1985; 44 : 139-266.
5. Duffy MJ. Do proteases play a role in cancer invasion and metastasis? Eur J Cancer Clin Oncol 1987; 23 : 583-9.
6. Grødahl-Hansen J, Christensen IJ, Rosenquit C, Brøner N, Mouridsen HT, Dan K, Blichert-Torf M. High levels of urokinase-type plasminogen activator and its inhibitor PAI-1 in cytosolic extracts of breast carcinomas are associated with poor prognosis. Cancer Res 1993; 53 : 2513-21.
7. Hong S-I, Hong W-S, Jang J-J, Lee D-S, Cho N-S, Jung M-E, Kim H-B, Ha G-W, Park I-C, Cho D-S, Lee J-I. Alteration of p53 gene in primary gastric cancer tissues. Anticancer Res 1994; 14 : 1251-6.
8. Laiho M, Keski-Oja J. Growth factors in the regulation of pericellular proteotysis : a review. Cancer Res 1989; 49 : 2533-53.
9. Liotta LA, Thorgeirsson UP, Garbisa S. Role of collagenases in tumor cell invasion. Cancer Metastasis Rev. 1982; 1 : 277-88.
10. Markus G. The relevance of plasminogen activators to neoplastic growth. A review of recent literature. Enzyme 1988; 40 : 153-72.
11. Moscatelli D, Rifkin DB. Membrane and matrix localization of proteinases : a common theme in tumor cell invasion and angiogenesis. Biochemica et Biophysica Acta 1988 ; 948 : 67-85.
12. Nekarda H, Schmitt M, Ulm K, Wenninger A Vogeelsang H, Becker K, Roder JD, Fink U, Siewert JR. Prognostic impact of urokinase-type plasminogen activator and its inhibitor PAI-1 in completely resected gastric cancer. Cancer Res 1994; 54 : 2900-7.
13. Nielsen LS, Kellerman GM, Behrendt N, Picone R, Danø K, Blasi F. A 55,000-60,000 Mr receptor protein for urokinase-type plasminogen activator. Identification in human tumor cell lines and partial purification. J Biol Chem 1988; 263 : 2358-63.
14. Nishino N, Aoki K, Tokura Y, Sakaguchi S, Takada Y, Takada A. The urokinase-type plasminogen activator in cancer of digestive tracts. Thromb Res 1988; 50 : 527-35.
15. Ossowski L, Reich E. Antibodies to plasminogen activation inhibit human tumor metastasis. Cell 1983; 35 : 611-9.
16. Pederen H, Brünner N, Francis D, Østerlind K, Rønne E, Hansen HH, Danø K, Grøndahl-Hansen J. Prognostic impact of urokinase, urokinase receptor and type 1 plasminogen activator inhibitor in squamous and large cell cancer tissue. Cancer Res 1994; 54 : 4671-5.
17. Plow EF, Freaney DE, Plescia J, Miles LA. The plasminogen system and cell surfaces : evidence for plasminogen and urokinase receptor on the same cell type. J Cell Biol 1986; 103 : 2411-20.
18. Pöllänen J, Stephens RW, Vaheri A. Directed plasminogen activation at the surface of normal and malignant cells. Adv Cancer Res 1991; 57 : 273-328.
19. Saksela O. Plasminogen activation and regulation of pericellular proteolysis. Biochem Biophys Acta 1985; 823 : 35-65.
20. Sakasela O, Rifkin DB. Cell-mediated plasminogen activation : Regulation and physiological functions. Ann Rev Cell Biol 1988; 4 : 93-126.
21. Sier CFM, Verspaget HW, Griffioen G, Verheijen JH, Quax PHA, Dooijewaard G, De Bruin PAF, Lamers CBHW. Inbalance of plasminogen activators and their inhibitors in human colorectal neoplasia. Implication of urokinase in colorectal carcinogenesis. Gastroentrol 1991; 101 : 1522-8.
22. Sprengers ED, Kluft C. Plasminogen activator inhibitors. Blood 1987; 69 : 381-7.
23. Stetler-Stevenson WG, Aznavoorian S, Liotta LA. Tumor cell interactions with the extracellular matrix during invasion and metastasis. Annu Rev Cell Biol 1993; 9 : 541-73.
24. Takai N, Yamamura M, Tanaka K, Kawanishi H, Tsuji M, Nakane Y, Hiroky K, Yamamoto M. Plasminogen activators in human gastric cancers : correlation with DNA ploidy and immunohistochemical staining. Int J Cancer 1991; 48 : 20-7.
25. Tissot J-D, Hauerrt J, Bachmann F. Characterization of plasminogen activators from normal human breast and colon and breast and colon carcinomas. Int J Cancer 1984; 34 : 295-302.
26. Vassalli J-D, Baccino D. Belin D, A cellular binding site for the Mr 55,000 form of the human plasminogen activator, uorkinase. J Cell Biol 1985; 100 : 86-92.
27. Yamamoto M, Sawaya R, Mohanam S, Rao VH, Bruner JM, Nicolson GL, Rao JS. Expression and localization of urokinase-type plasminogen activator receptor in human gliomas. Cancer Res 1994; 54 : 5016-20.