New insight on immune tolerance from transgenic mouse models

Journal of Korean Medical Science

Volumn 11, Issue 1, 1996, Pages 1-7

  Lee, Myung Shik ^a  

^a Samsung Medical Center   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; LYMPHOCYTE ANTIGEN RECEPTOR; VIRUS ANTIGEN;

ANIMAL; GENE; GENETICS; IMMUNOLOGICAL TOLERANCE; MOUSE; REVIEW; TRANSGENIC MOUSE;

ANIMALS; ANTIGENS, VIRAL; CYTOKINES; GENES, MHC CLASS II; IMMUNE TOLERANCE; MICE; MICE, TRANSGENIC; RECEPTORS, ANTIGEN, T-CELL;

EID: 0030076275     PISSN: 10118934     EISSN: None     Source Type: Journal    
DOI: 10.3346/jkms.1996.11.1.1     Document Type: Article

References (29)

1. Arnold B, Schoenrich G, Haemmerling G. Multiple levels of peripheral tolerance. Immunol Today 1993; 14 : 12-4.
2. Boehme J, Haskins K, Stecha P, van Ewijk W, LeMeur M, Gerlinger P, Benoist C, Mathis D. Transgenic mice with I-A on islet cells are normoglycemic but immunologically intolerant. Science 1989; 244 : 1179-83.
3. Bottazzo GF, Dean BM, McNally JM, Mackay EH, Swift PGF, Gamble DR. In situ characterization of autoimmune phenomena and expression of HLA molecules in the pancreas of diabetic insulitis. N Engl J Med 1985; 313 : 353-60.
4. Bottazzo GF, Pujol-Borrell R, Hanafusa T. Role of aberrant HLA-DR expression and antigen presentation in induction of endocrine autoimmunity. Lancet 1983; 2: 1115-8.
5. Foester I, Hirose R, Arbeit JM, Clausen BE, Hanahan D. Limited capacity for tolerization of CD4+ T cells specific for a pancreatic b cell neo-antigen. Immunity 1995; 2, : 573-85.
6. Fujinami RS, Oldstone MBA. Amino acid homology between the encephalitogenic site of myelin basic protein and virus : mechanism for autoimmunity. Science 1985; 230 : 1043-5.
7. Geiger T, Gooding LR, Flavell RA. T-cell responsiveness to an oncogenic peripheral protein and spontaneous autoimmunity in transgenic mice. Proc Natl Acad Sci USA 1992; 89: 2985-9.
8. Goverman J, Woods A, Larson L, Weiner LP, Hood L, Zaller DM. Transgenic mice tht express a myelin basic protein-specific T cell receptor develop spontaneous autimmunity. Cell 1993; 72 : 551-60.
9. Hanafusa T, Pujon-Borrel R, Chivato L, Russel RCG, Doniach D, Bottazzo GF. Aberrant expression of HLA-DR ntigen on thyrocytes in Graves' disease: relevance for autoimmunity. Lancet 1983; 2 : 1111-5.
10. Jansson R, Lartsson A, Forsum U. Intrathyroidal HLA-DR epression and T-lymphocyte phenotypes in Graves' thyrotoxicosis, Hashimoto's thyroiditis and nodular colloid goiter. Clin Exp Immunol 1984; 58 : 264-72.
11. Katz JD, Wang B, Haskins K, Benoist C, Mathis D. Following a diabetogenic T cell from genesis through pathogenesis. Cell 1993; 74 : 1089-100.
12. Lee M-S, Cho BY, Kim SY, Lee HK, Koh C-S, Min HK, Lee J-H, Kang T-W. Cycloheximide inhibits interferon-γ -induced class II major histocompatibility complex antigen expression in cultured rat thyroid cells. Endocrinology 1991; 128 : 1527-31.
13. Lee M-S, Sarvetnick N. Induction of vascular addressins and adhesion molecules in the pancreas of IFN-γ transgenic mice. J Immunol 1994; 152 : 4597-603.
14. Lee M-S, Shong YK, Cho BY, Lee HK, Koh C-S, Min HK, Lee M. HLA-DR antigen expression on the thyrocytes of Graves' disease patients. Korean J Intern Med 1988; 3 : 15-23.
15. Lee M-S, von Herrath M, Reiser H, Oldstone MBA, Sarvetnick N. Sensitization to self (virus) antigen by in situ expression of marine interferon-γ. J Clin Invest 1995; 95 : 486-92.
16. Lo D, Burkly LC, Widera G, Cowing C, Ravell RA, Palmiter RD, Brinster RL Diabetes and tolerance in transgenic mice expressing class II MHC molecules in pancreatic beta cells. Cell 1988; 53 : 159-68.
17. Lo D, Freedman J, Hesse S, Palmiter RD, Brinster RL, Sherman LA Peripheral tolerance to an islet specific hemagglutinin transgene affects both CD4+ and CD8+ T cells. Eur J Immunol 1992; 22 : 1013-22.
18. Londei M, Lamb JR, Bottazzo GF, Feldmann M. Epithelial cells expressing aberrant MHC class II determinants can present antigen to cloned human T cells. Nature 1984; 312 : 639-41.
19. Markmann J, Lo D, NaJi A, Palmiter RD, Brinster RL, Heber-Katz E. Antigen presenting function of class II MHC expressing pancreatic beta cells. Nature 336: 476-479, 1988.
20. Miller J, Daitch L, Rath S, Selsing E. Tissue-specific expression of allogeneic class II MHC molecules induces neither tissue rejection nor clonal inactivation of alloreactive T cells. J Immunol 1990; 144 : 334-41.
21. Mogil RJ, Radvanyi L, Gonzalez-Quintial G, Miller R, Mills G, Theofilopoulos AN, Green DR. Fas (CD95) participates in peripheral T cell deletion and associated apoptosis in vivo. Int Immunol 1995; 7 : 1451-8.
22. Oldstone MBA, Nerenberg M, Southern P, Price J, Lewicki, H. Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model:role of anti-self (virus) immune response. Cell 1991; 65 : 319-31.
23. Ohashi PS, Oehen S, Buerki K, Pricher H, Ohashi CT, Odermatt B, Malissen B, Znkemagel RM, Hengartner H. Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice. Cell 1991 ; 65 : 305-17.
24. Piccinini LA, Mackenzie WA, Platzer M, Davies TF. Lymphokine regulation of HLA-DR gene expression in human thyroid cell monolayers. J Clin Endocrinol Metab 1987; 64 : 543-8.
25. Quill H, Schwartz RH. Stimulation of normal inducer. T cell clones with antigen presented by purified la molecules in planar lipid membranes : specific induction of a long-lived state of proliferative nonresponsiveness. J Immunol 1987; 138 : 3704-12.
26. Sarvetnick N. Transgenic mouse model for growth factor studies. Methods Enzymol 1991; 49 : 519-25.
27. Sarvetnick N, Ligitt D, Pitts SL, Hansen SE, Stewart TA. Insulin-dependent diabetes mellitus induced in transgenic mice by ectopic expression of class II MHC and interferon-gamma. Cell 1988; 52 : 773-82.
28. Scott B, Liblau R, Degermann S, Marconi LA, Ogata L, Caton AJ, McDevitt HO, Lo D. A role for non-MHC genetic polymorphism in susceptibility to spontaneous autoimmunity. Immunity 1994; 1 : 73-82.
29. Tafuri A, Alferink J, Moeller P, Haemmering GJ, Arnold B. T cell awareness of paternal alloantigens during pregnancy. Science 1995; 270 : 630-3.