Determinants of in vivo activity of neutral endopeptidase 3.4.24.11 and angiotensin converting enzyme inhibitors

Journal of Pharmacology and Experimental Therapeutics

Volumn 276, Issue 2, 1996, Pages 708-713

  Seymour, Andrea Ann ^a   Asaad, Magdi M ^a   Abboa Offei, Benoni E ^a   Smith, Patricia L ^a   Rogers, W Lynn ^a   Dorso, Charles R ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; ATRIAL NATRIURETIC FACTOR; CAPTOPRIL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DRUG DERIVATIVE; MEMBRANE METALLOENDOPEPTIDASE; N (2 MERCAPTOMETHYL 3 PHENYLPROPIONYL) BETA ALANINE; PEPTIDE FRAGMENT;

ANIMAL; ARTICLE; BLOOD PRESSURE; DRUG ANTAGONISM; DRUG EFFECT; FEMALE; HUMAN; KIDNEY; MACACA;

ALANINE; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; ATRIAL NATRIURETIC FACTOR; BLOOD PRESSURE; CAPTOPRIL; FEMALE; HUMANS; KIDNEY; MACACA FASCICULARIS; NEPRILYSIN; PEPTIDE FRAGMENTS;

EID: 0030075565     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. CAVERO, G. C., MARGULIES, K. B., WINAVER, J., SEYMOUR, A. A., DELANEY, N. G. AND BURNETT JR., J. C.: Cardiorenal actions of neutral endopeptidase inhibition in experimental congestive heart failure. Circulation 82: 196-201, 1990.
2. MIZELLE, H. L., HALL, J. E. AND HILDEBRANDT, D. A : Atrial natriuretic peptide and pressure natriuresis: Interactions with the renin-angiotensin system. Am. J. Physiol. 257: R1169-R1174, 1989.
3. MOTWANI, J. G., LANG, C. C., CRAMB, G. AND STRUTHERS, A. D.: Natriuretic response to neutral endopeptidase inhibition is blunted by enalapril in health men. Hypertension 25(part 1): 637-642, 1995.
4. PHAM, I., El AMRANI, A-I. K., FOURNIE-ZALUSKI, M. C., CORVOL, P., ROQUES, B. AND MICHEL, J. B.: Effects of the selective neutral endopeptidase inhibitor, retrothiorphan, on renal function and blood pressure in conscious normotensive Wistar and hypertensive DOCA-Salt rats. J., Pharmacol. 20: 847-857, 1992.
5. PHAM, I., GONZALEZ, W., EL AMRANI, A-I. K., FOURNIE-ZALUSKI, M.-C., PHILLIPPE, M., LABOULANDINE, I., ROQUES, B. P. AND MICHEL J.-B.: Effects of converting enzyme inhibitor and neutral endopeptidase inhibitor on blood pressure and renal function in experimental hypertension. J. Pharmacol. Exp. Ther. 268: 1339-1347, 1993.
6. RICHARDS, M., ESPINER, E., FRAMPTON, C., IKRAM, H., YANDLE, T., SOPWITH, M. AND CUSSANS, N.: Inhibition of endopeptidase EC 24.11 in humans: Renal and endocrine effects. Hypertension 16: 269-276, 1990.
7. ROQUES, B. P., NOBLE, F., DAUGE, V., FOURNIE-ZALUSKI, M.-C. AND BEAUMONT, A.. Neutral endopeptidase 24.11: Structure, inhibition, and experimental and clinical pharmacology. Pharmacol. Rev 45: 87-145, 1993.
8. SCALESE, R. J., DEFORREST, J. M., HAMMERSTONE, S., PARENTE, E. AND BURKETT, D. E.: Long term vascular catheterization of the cynomolgus monkey. Lab. Animal Sci. 40: 530-532, 1990.
9. SEYMOUR, A. A.: The pharmacology of SQ 28,603, an inhibitor of neutral endopeptidase 3.4.24.11. Cardiovasc Drug Rev. 9: 285-298, 1991a.
10. SEYMOUR A. A., ABBOA-OFFEI, B., ASAAD, M. M. AND ROGERS, W. L.: Evaluation of SQ 28,603, an inhibitor of neutral endopeptidase, in conscious monkeys. Can. J. Physiol. Pharmacol. 69: 1609-1617, 1991b.
11. SEYMOUR, A. A., ASAAD, M. M., LANOCE, V. M., LANGENBACHER, K. M., FENNELL, S. A. AND ROGERS, W. L.: Systemic Hemodynamics, renal function and hormonal levels during inhibition of neutral endopeptidase 3.4.24.11 and angiotensin-converting enzyme in conscious dogs with pacing-induced heart failure. J. Pharmacol. Exp. Ther. 266: 872-883, 1993.
12. SEYMOUR, A. A., FENNELL, S. A. AND SWERDEL, J. N : Potentiation of renal effects of atrial natriuretic factor-(99-126) by SQ 29,072. Hypertension 14: 87-97, 1989.
13. SEYMOUR, A. A., NORMAN, J. A., ASAAD, M. M., FENNELL, S. A., SWERDEL, J. N., LITTLE, D. K. AND DORSO, C. R.: Renal and depressor effects of SQ 29,072, a neutral endopeptidase inhibitor, in conscious hypertensive rats. J. Cardiovasc. Pharmacol. 16: 163-172, 1990.
14. SEYMOUR, A. A., SHELDON, J. H., SMITH, P. L., ASAAD, M. AND ROGERS, W. L.: Potentiation of the renal responses to bradykinin by inhibition of neutral endopeptidase 3.4.24.11 and angiotensin converting enzyme in anesthetized dogs. J. Pharmacol. Exp. Ther. 269: 263-270, 1994.
15. SEYMOUR, A. A., SWERDEL, J. N. AND ABBOA-OFFEI, B.: Antihypertensive activity during inhibition of neutral endopeptidase and angiotensin converting enzyme. J. Cardiovasc. Pharmacol. 17: 456-465, 1991c.
16. SHOWALTER, C. J., ZIMMERMAN, R. S., SCHWAB, T. R., EDWARDS, B. S., OPGENORTH, T. J. AND BURNETT, JR. J. C.: Renal response to atrial natriuretic factor is modulated by intrarenal angiotensin II. Am. J. Physiol. 254: R453-R456, 1988.
17. SKIDGEL, R. A., SCHULZ, W. W., TAM, L.-T. AND ERDOS, E. G.: Human renal angiotensin I converting enzyme and neutral endopeptidase. Kidney Int. 31: S45-S48, 1987.
18. SMITH, J. B. AND LINCOLN, T. M.: Angiotensin decreases cyclic GMP accumulation produced by atrial natriuretic factor. Am. J. Physiol. 253: C147-C150, 1987.
19. SYBERTZ, E. J : Drugs inhibiting the metabolism and inactivation of atrial natriuretic factor: Pharmacological actions and therapeutic implications. Cardiovasc. Drug Rev. 8: 71-82, 1990.
20. SYBERTZ, E. J., CHIU, P. J., VEMULAPALLI, S., PITTS, B , FOSTER, C. J., WATKINS, R. W., BARNETT, A. AND HASLANGER, M. F.: SCH 39370, a neutral metalloendopeptidase inhibitor, potentiates biological responses to atrial natriuretic factor and lowers blood pressure in desoxycorticosterone acetate-sodium hypertensive rats. J. Pharmacol. Exp. Ther. 250: 624-631, 1989.
21. VANNESTE, Y., PAUWELS, S., LAMBOTTE, L. AND DESCHODT-LANCKMAN, M.: In vivo metabolism of brain natriuretic peptide in the rat involves endopeptidase 24.11 and angiotensin converting enzyme. Biochem. Biophys. Res. Commun. 173: 265-271, 1990.