메뉴 건너뛰기




Volumn 1, Issue 4, 1996, Pages 207-212

Biological assessment and MRI monitoring of the therapeutic efficacy of a monoclonal anti-T CD4 antibody in multiple sclerosis patients

Author keywords

Anti T cell CD4 BF5 mAB; Cytokines; Monoclonal antibody; MRI; Multiple sclerosis (MS); Phase 1 open trial

Indexed keywords

CD4 ANTIGEN; MONOCLONAL ANTIBODY;

EID: 0030072648     PISSN: 13524585     EISSN: None     Source Type: Journal    
DOI: 10.1177/135245859600100404     Document Type: Article
Times cited : (17)

References (28)
  • 1
    • 0028158451 scopus 로고
    • The treatment of multiple sclerosis
    • Ebers GC. (1994) The treatment of multiple sclerosis. Lancet 343: 275-279.
    • (1994) Lancet , vol.343 , pp. 275-279
    • Ebers, G.C.1
  • 2
    • 0028054691 scopus 로고
    • Immunotherapy for multiple sclerosis
    • Hughes R. (1994) Immunotherapy for multiple sclerosis. J Neurol Neurosurg Psychiatr 57: 3-6.
    • (1994) J Neurol Neurosurg Psychiatr , vol.57 , pp. 3-6
    • Hughes, R.1
  • 3
    • 0027162788 scopus 로고
    • Advances in the understanding and treatment of multiple sclerosis
    • Reingold SC. (1993) Advances in the understanding and treatment of multiple sclerosis. J Neuroimmunol 44: 221-224.
    • (1993) J Neuroimmunol , vol.44 , pp. 221-224
    • Reingold, S.C.1
  • 4
    • 0026018158 scopus 로고
    • An open trial of OKT3 in patients with multiple sclerosis
    • Weinshenker BG et al. (1991) An open trial of OKT3 in patients with multiple sclerosis. Neurology 41: 1047-1052.
    • (1991) Neurology , vol.41 , pp. 1047-1052
    • Weinshenker, B.G.1
  • 5
    • 0342429545 scopus 로고
    • Phase I study of chimeric anti-D4 monoclonal antibody in multiple sclerosis
    • Hodgkinson S et al. (1992) Phase I study of chimeric anti-D4 monoclonal antibody in multiple sclerosis. Neurology 42 (suppl. 3): P. 209, 242S.
    • (1992) Neurology , vol.42 , Issue.3 SUPPL. , pp. 209
    • Hodgkinson, S.1
  • 6
    • 0028280845 scopus 로고
    • Phase 1 clinical trial of chimeric monoclonal anti-CD4 antibody in multiple sclerosis
    • Lindsey JW et al. (1994) Phase 1 clinical trial of chimeric monoclonal anti-CD4 antibody in multiple sclerosis. Neurology 44: 413-419.
    • (1994) Neurology , vol.44 , pp. 413-419
    • Lindsey, J.W.1
  • 7
    • 0028024182 scopus 로고
    • Repeated treatment with chimeric anti-CD4 antibody in multiple sclerosis
    • Lindsey JW et al. (1994) Repeated treatment with chimeric anti-CD4 antibody in multiple sclerosis. Ann Neurol 36: 183-189.
    • (1994) Ann Neurol , vol.36 , pp. 183-189
    • Lindsey, J.W.1
  • 8
    • 0028086142 scopus 로고
    • Essai thérapeutique ouvert d'un anticorps monoclonal anti-T CD4 dans la sclérose en plaques
    • Rumbach L et al. (1994) Essai thérapeutique ouvert d'un anticorps monoclonal anti-T CD4 dans la sclérose en plaques. Rev Neurol 150: 418-424.
    • (1994) Rev Neurol , vol.150 , pp. 418-424
    • Rumbach, L.1
  • 9
    • 0028236827 scopus 로고
    • Are magnetic resonance findings predictive of clinical outcome in therapeutic trials in multiple sclerosis? the dilemma of interferon-β
    • McDonald WI, Miller DH, Thompson AJ. (1994) Are magnetic resonance findings predictive of clinical outcome in therapeutic trials in multiple sclerosis? The dilemma of interferon-β. Ann Neurol 36: 14-18.
    • (1994) Ann Neurol , vol.36 , pp. 14-18
    • McDonald, W.I.1    Miller, D.H.2    Thompson, A.J.3
  • 10
    • 0027521002 scopus 로고
    • Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. II. MRI analysis results of a multicentre, randomized, double-blind, placebo-controlled trial
    • Paty DW, Li DKB, the UBC MS/MRI Study Group and the IFNβ Multiple Sclerosis Study Group. (1993) Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. II. MRI analysis results of a multicentre, randomized, double-blind, placebo-controlled trial. Neurology 43: 662-667.
    • (1993) Neurology , vol.43 , pp. 662-667
    • Paty, D.W.1    Li, D.K.B.2
  • 11
    • 0026733408 scopus 로고
    • Immunological follow-up of 17 patients with rheumatoid arthritis treated in vivo with an anti-CD4 monoclonal antibody (BF5)
    • Racadot E, Wijdenes P, Wendling D. (1992) Immunological follow-up of 17 patients with rheumatoid arthritis treated in vivo with an anti-CD4 monoclonal antibody (BF5). Clin Exp Rhumatol 10: 365-374.
    • (1992) Clin Exp Rhumatol , vol.10 , pp. 365-374
    • Racadot, E.1    Wijdenes, P.2    Wendling, D.3
  • 12
    • 0027787937 scopus 로고
    • Treatment of multiple sclerosis with anti-CD4 monoclonal antibody. A preliminary report on B-F5 in 21 patients
    • Racadot E et al. (1993) Treatment of multiple sclerosis with anti-CD4 monoclonal antibody. A preliminary report on B-F5 in 21 patients. J Autoimmun 6: 771-786.
    • (1993) J Autoimmun , vol.6 , pp. 771-786
    • Racadot, E.1
  • 13
    • 0023759102 scopus 로고
    • Anti-CD4 and anti-CD2 monoclonal antibody infusions in subjects with multiple sclerosis, immunosuppressive effect and human anti-mouse responses
    • Hafler DA, Ritz F, Schlossman SF, Weiner HL. (1988). Anti-CD4 and anti-CD2 monoclonal antibody infusions in subjects with multiple sclerosis, immunosuppressive effect and human anti-mouse responses. J Immunol 141: 131-138.
    • (1988) J Immunol , vol.141 , pp. 131-138
    • Hafler, D.A.1    Ritz, F.2    Schlossman, S.F.3    Weiner, H.L.4
  • 14
    • 0028346432 scopus 로고
    • Preliminary evidence from magnetic resonance imaging for reduction in disease activity after lymphocyte depletion in multiple sclerosis
    • Moreau T et al. (1994) Preliminary evidence from magnetic resonance imaging for reduction in disease activity after lymphocyte depletion in multiple sclerosis. Lancet 344: 298-301.
    • (1994) Lancet , vol.344 , pp. 298-301
    • Moreau, T.1
  • 15
    • 0027093377 scopus 로고
    • Treatment of rheumatoid arthritis with anti-CD4 monoclonal antibody. Open study of 25 patients with the BF5 clone
    • Wendling D, Racadot E, Morel-Fourrier B, Wijdenes J. (1992) Treatment of rheumatoid arthritis with anti-CD4 monoclonal antibody. Open study of 25 patients with the BF5 clone. Clin Rheumatol 11: 542-547.
    • (1992) Clin Rheumatol , vol.11 , pp. 542-547
    • Wendling, D.1    Racadot, E.2    Morel-Fourrier, B.3    Wijdenes, J.4
  • 16
    • 0021816056 scopus 로고
    • A randomized clinical trial of OKT3 monoclonal antibody for acute rejection of cadaveric renal transplants
    • Ortho Multicenter Transplant Study Group. (1985) A randomized clinical trial of OKT3 monoclonal antibody for acute rejection of cadaveric renal transplants. N Engl J Med 313: 337-341.
    • (1985) N Engl J Med , vol.313 , pp. 337-341
  • 17
    • 0025260903 scopus 로고
    • Interleukin-6 an overview
    • Van Snick JV. (1990) Interleukin-6 an overview. Annu Rev Immunol 8: 253-278.
    • (1990) Annu Rev Immunol , vol.8 , pp. 253-278
    • Van Snick, J.V.1
  • 18
    • 0023904746 scopus 로고
    • Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro
    • Selmaj K, Raine CS. (1988) Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro. Ann Neurol 23: 339-346.
    • (1988) Ann Neurol , vol.23 , pp. 339-346
    • Selmaj, K.1    Raine, C.S.2
  • 19
    • 0026844653 scopus 로고
    • Inter- And Intrarater scoring variability using grades 1.0-3.5 of the Kurtzke expanded disability status scale (EDSS)
    • Goodkin DE et al. (1992) Inter- and Intrarater scoring variability using grades 1.0-3.5 of the Kurtzke expanded disability status scale (EDSS). Neurology 42: 859-863.
    • (1992) Neurology , vol.42 , pp. 859-863
    • Goodkin, D.E.1
  • 20
    • 0025314243 scopus 로고
    • Interrater variability with the expanded disability status scale (EDSS) and functional systems (FS) in a multiple sclerosis clinical trial
    • Noseworthy JH, Vandervoort MK, Wong CJ, Ebers GC, and the Canadian Cooperative MS Study Group. (1990) Interrater variability with the expanded disability status scale (EDSS) and functional systems (FS) in a multiple sclerosis clinical trial. Neurology 40: 971-975.
    • (1990) Neurology , vol.40 , pp. 971-975
    • Noseworthy, J.H.1    Vandervoort, M.K.2    Wong, C.J.3    Ebers, G.C.4
  • 21
    • 0027418515 scopus 로고
    • Interferon-beta-1b is effective in relapsing-remitting multiple sclerosis. I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial
    • The IFNB Multiple Sclerosis Study Group. (1991) Interferon-beta-1b is effective in relapsing-remitting multiple sclerosis. I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial. Neurology 43: 655-661.
    • (1991) Neurology , vol.43 , pp. 655-661
  • 22
    • 0025909131 scopus 로고
    • Immunological effects of high dose administration of anti-CD4 antibody in rheumatoid arthritis patients
    • Golberg D, Morel P, Chatenoud L, Boitard C. (1991) Immunological effects of high dose administration of anti-CD4 antibody in rheumatoid arthritis patients. J Autoimmun 4: 617-630.
    • (1991) J Autoimmun , vol.4 , pp. 617-630
    • Golberg, D.1    Morel, P.2    Chatenoud, L.3    Boitard, C.4
  • 23
    • 0025829708 scopus 로고
    • Treatment of rheumatoid arthritis with monoclonal CD4 antibody M-T151
    • Reiter C et al. (1991) Treatment of rheumatoid arthritis with monoclonal CD4 antibody M-T151. Arthritis Rheum 34: 525-536.
    • (1991) Arthritis Rheum , vol.34 , pp. 525-536
    • Reiter, C.1
  • 24
    • 0025830117 scopus 로고
    • Therapeutic use of monoclonal anti-CD4 antibody in rheumatoid arthritis
    • Wendung D, Wijdenes J, Racadot E, Morel-Fourrier B. (1991) Therapeutic use of monoclonal anti-CD4 antibody in rheumatoid arthritis. J Rheumatol 18: 325-327.
    • (1991) J Rheumatol , vol.18 , pp. 325-327
    • Wendung, D.1    Wijdenes, J.2    Racadot, E.3    Morel-Fourrier, B.4
  • 25
    • 0027503243 scopus 로고
    • Use of a chimeric monoclonal anti-CD4 antibody in patients with refractory rheumatoid arthritis
    • Moreland LW et al. (1993) Use of a chimeric monoclonal anti-CD4 antibody in patients with refractory rheumatoid arthritis. Arthritis Rheum 36: 307-318.
    • (1993) Arthritis Rheum , vol.36 , pp. 307-318
    • Moreland, L.W.1
  • 26
    • 0025854083 scopus 로고
    • Serial gadolinium-enhanced magnetic resonance imaging scans in patients with early, relapsing-remitting multiple sclerosis: Implications for clinical trials and natural history
    • Harris JO et al. (1991) Serial gadolinium-enhanced magnetic resonance imaging scans in patients with early, relapsing-remitting multiple sclerosis: implications for clinical trials and natural history. Ann Neurol 29: 548-555.
    • (1991) Ann Neurol , vol.29 , pp. 548-555
    • Harris, J.O.1
  • 27
    • 0026474514 scopus 로고
    • Using gadolinium-enhanced magnetic resonance imaging lesions to monitor disease activity in multiple sclerosis
    • McFarlan HF et al. (1992) Using gadolinium-enhanced magnetic resonance imaging lesions to monitor disease activity in multiple sclerosis. Ann Neurol 32: 758-766.
    • (1992) Ann Neurol , vol.32 , pp. 758-766
    • McFarlan, H.F.1
  • 28
    • 0025741072 scopus 로고
    • Magnetic resonance imaging in monitoring the treatment of multiple sclerosis
    • Miller DH et al. (1991) Magnetic resonance imaging in monitoring the treatment of multiple sclerosis. J Neurol Neurosurg Psychiatr 54: 683-688.
    • (1991) J Neurol Neurosurg Psychiatr , vol.54 , pp. 683-688
    • Miller, D.H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.