Ototoxicity of tobramycin in young adult and old rats

Toxicology and Applied Pharmacology

Volumn 136, Issue 1, 1996, Pages 179-185

  Dormans, J A M A ^a   Peters Volleberg, G W M ^a   Dortant, P M ^a   Speijers, G J A ^a  

^a NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

TOBRAMYCIN; TOBRAMYCIN SULFATE;

ADULT; AGE; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COCHLEA; CONTROLLED STUDY; FEMALE; HAIR CELL; NONHUMAN; OTOTOXICITY; RAT; SCANNING ELECTRON MICROSCOPY; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0030071510     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1996.0022     Document Type: Article

References (17)

1. Astbury, P. J., and Read, N. G. (1982). Improved morphological technique for screening potentially ototoxic compounds in laboratory animals. Br. J. Audiol 16, 131-137.
2. Bjorksten, J., Yaeger, L. L., and Wallace, T. (1988). Control of aluminium ingestion and its relation to longevity. Int. J. Vit. Nutr. Res. 58, 462-465.
3. Bohne, B. A., and Harding, G. W. (1993). Combined organ of Corti Modiolus technique for preparing mammalian cochleas for quantitative microscopy. Hearing Res. 71, 114-124.
4. Brummett, R. E., Himes, D., Saine, B., and Vernon, J. (1972). A comparative study of the ototoxicity of tobramycin and gentamicin. Arch. Otolaryng. 96, 505-512.
5. Cotanche, D. A., Lee, K., Stone, J., and Picard, D. (1994). Hair cell regeneration in the bird cochlea following noise damage or ototoxic drug damage. Anat. Embryol. 189, 1-18.
6. Davies, S., and Forge, A. (1987). Preparation of the mammalian organ of Corti for scanning electron microscopy. J. Micr. 147, 89-101.
7. Department of Health and Human Services (1994). National Toxicology Programme 1994, p. 45.
8. Dupont, J., Guilhaume, A., and Aran, J.-M. (1993). Degeneration and reorganization of vestibular epithelia after local aminoglycoside application in the mammalian inner ear. Scanning Micr. 7, 597-612.
9. Huang, M. Y., and Schacht, J. (1989). Drug-induced ototoxicity. Pathogenesis and prevention. Med. Toxicol. Adverse Drug Exp. 4, 452-467.
10. Kessel, R. G., and Kardon, R. H. (1979). Cellen, weefsels en organen. Een scanningelektronenmikroskopische studie-atlas, pp. 106-118. Natuur en Techniek, Maastricht.
11. Liberman, M. Ch. (1990). Quantitative assessment of inner ear pathology following ototoxic drugs or acoustic trauma. Toxicol. Pathol. 18, 138-148.
12. Mizuta, K., Nozawa, O., Morita, H., and Hoshino, T. (1993). Scanning electron microscopy of age-related changes in the C57BL/6J mouse cochlea. Scanning Micr. 7, 889-896.
13. Reidenberg, M. M. (1980). Drugs in the elderly. Bull. N.Y. Acad. Med. 56, 703-714.
14. Soudijn, E. R. (1976). Scanning electron microscopic study of the organ of Corti in normal and sound-damaged guinea pigs. Ann. Otol. Rhinol. Laryng. 85, part 2, Suppl. 29.
15. Stone, J. S., and Cotanche, D. A. (1994). Identification of the timing of S-phase and the pattern of cell proliferation during hair cell regeneration in the chick cochlea. J. Comp. Neurol. 341, 50-67.
16. Willott, J. F. (1986). Effects of aging, hearing loss and anatomical location on thresholds of inferior colliculus neurons in C57BL/6 and CBA mice. J. Neurophys. 56, 391-408.
17. World Health Organization (1993). Environmental Health Criteria of the International Programme on Chemical Safety, Document 144: Principles for evaluating chemical effects on the aged population.