Further elucidation of pharmacokinetic interaction between diltiazem and warfarin

International Journal of Clinical Pharmacology and Therapeutics

Volumn 34, Issue 2, 1996, Pages 56-60

  Stoysich, A M ^a   Lucas, B D ^a   Mohiuddin, S M ^a   Hilleman, D E ^a  

^a CREIGHTON UNIVERSITY   (United States)

Author keywords

Diltiazem; Metabolism; Pharmacokinetics; Protein binding; Warfarin

Indexed keywords

DILTIAZEM; WARFARIN;

ADULT; ANTICOAGULATION; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG METABOLISM; DRUG PROTEIN BINDING; EQUILIBRIUM DIALYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; LIVER CLEARANCE; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; RANDOMIZED CONTROLLED TRIAL;

ADULT; ANTICOAGULANTS; CALCIUM CHANNEL BLOCKERS; CROSS-OVER STUDIES; DILTIAZEM; DRUG INTERACTIONS; HUMANS; LIVER; MALE; MIDDLE AGED; PROTEIN BINDING; REFERENCE VALUES; WARFARIN;

EID: 0030071434     PISSN: 09461965     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Abernethy DR, Egan JM, Dickinson TH, Carrum G 1988 Substrate-selective inhibition by verapamil and diltiazem: differential disposition of antipyrine and theophylline in humans. J Pharmacol Exp Ther 244: 994-999
2. Abernethy DR, Kaminsky LS, Dickinson TH 1991 Selective inhibition of warfarin metabolism by diltiazem in humans. J Pharmacol Exp Ther 257: 411-415
3. Bloedow DC, Piepho RW, Nies AS, Gal J 1982 Serum binding of diltiazem in humans. J Clin Pharmacol 22: 201-205
4. Brodie MJ, Macphee GJA 1986 Carbamazepine neurotoxicity precipitated by diltiazem. Br Med J 292: 1170-1171
5. Carrum G, Egan JM, Abernethy DR 1986 Diltiazem treatment impairs hepatic drug oxidation. Studies of antipyrine. Clin Pharmacol Ther 40: 140-143
6. Gibaldi M, Perrier D 1982 Pharmacokinetics. Dekker, New York, pp 409-417
7. Hirsh J, Dalen JE, Deykin D, Poller L 1992 Oral anticoagulants - mechanism of action, clinical effectiveness, and optimal therapeutic range. Chest 702: 312S-326S
8. Jusko WJ, Gretch M 1976 Plasma and tissue binding of drugs in pharmacokinetics. Drug Metab Rev 5: 43-140
9. MacKichan JJ 1984 Pharmacokinetic consequences of drug displacement from blood and tissue proteins Clin Pharmacokinet 9: 32-41
10. Mungall DR, Ludden TM, Hawkins DW, Tabor TA, Penn DH, Crawford MH 1984 Effect of diltiazem on warfarin plasma protein binding. J Clin Pharmacol 24: 264-266
11. Nafziger AN, May JJ, Bertino JS Jr 1987 Inhibition of theophylline elimination by diltiazem therapy. J Clin Pharmacol 27: 862-865
12. Ohashi K, Tateishi T, Sudo T, Sakamoto K, Toyosaki N. Hosoda S et al 1990 Effects of diltiazem on the pharmacokinetics of nifedipine. J Cardiovasc Pharmacol 15: 96-101
13. Tateishi T, Nakashima H, Shitou T, Kumagai Y, Ohashi K, Hosoda S, Ebihara A 1989a Effect of diltiazem on the pharmacokinetics of propranolol, metoprolol and atenolol. Eur J Clin Pharmacol 36: 67-70
14. Tateishi T, Ohashi K, Sudo T, Sakamoto K, Toyosaki N, Hosoda S et al 1989b Dose dependent effect of diltiazem on the pharmacokinetics of nifedipine. J Clin Pharmacol 29: 994-997
15. Yacobi A, Wall JA, Levy G 1976 Serum protein binding as a determinant of warfarin body clearance and anticoagulant effect. Clin Pharmacol Ther 19: 552-558