Orally delivered methadone as a reinforcer in rhesus monkeys

Psychopharmacology

Volumn 123, Issue 2, 1996, Pages 111-118

  Stewart, Robert B ^a,b   Grabowski, John ^a   Wang, Nian Sheng ^a   Meisch, Richard A ^a  

^a UNIVERSITY OF TEXAS   (United States)

^b INDIANA UNIVERSITY   (United States)

Author keywords

Alcohol; Drug reinforcement; Drug self administration; Ethanol; Fading procedure; Methadone; Opioid; Oral route; Rhesus monkeys

Indexed keywords

ALCOHOL; METHADONE; WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG PREFERENCE; DRUG SELF ADMINISTRATION; INSTRUMENTAL CONDITIONING; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; REINFORCEMENT; RHESUS MONKEY;

ADMINISTRATION, ORAL; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; MACACA MULATTA; MALE; METHADONE; REINFORCEMENT (PSYCHOLOGY);

EID: 0030071407     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02246167     Document Type: Article

References (40)

1. Altshuler HL (1978) The use of self-adminisiration for assessing the action of the opiates. In: Adler ML, Manara L, Samanin R (eds) Factors affecting the action of narcotics. Raven Press New York, pp 173-192
2. Altshuler H, Weaver S, Phillips P (1975) Intragastric self-administration of psychoactive drugs by the rhesus monkey. Life Sci 17:883-890
3. Carroll ME, Mcisch RA (1984) Enhanced drug-reinforced behavior due to food deprivation. In: Thompson T, Dews PB, Barrett JE (eds) Advances in behavioral pharmacology (vol. 4). Academic Press, New York, pp 47-88
4. Chipkin RE, Rosecrans JA (1978) Aversiveness of oral methadone in rats. Psychopharmacology 57: 303-310
5. Claghorn JD, Ordy JM, Nagy A (1965) Spontaneous opiate addiction in rhesus monkeys. Science 149: 440-441
6. Collins RJ, Wecks JR (1965) Relative potency of codeine, methadone and dihydromorphine to morphine in self-maintained addict rats. Naunyn-Schmiedeberg's Arch Exp Pathol 249: 509-514
7. Committee on Care and Use of Laboratory Animal Resources, Commission on Life Sciences National Research Council (1985) Guide lor the care and use of laboratory animals. US Department of Health and Human Services, Public Health Service, National Institutes of Health. NIH Publication NO. 25-83, US Government Printing Office Washington DC
8. Crowley TJ, Hydinger M, Stynes AJ, Feiger A (1975) Monkey motor stimulation and altered social behavior during chonic methadone administration. Psychopharmacologia 43: 135-144
9. Deneau G, Yanagita T, Seevers MH (1969) Self-administration of psychoactive substances by the monkey. Psychopharmacologia 16:3048
10. Dole VP, Nyswander ME (1965) A medical treatment for diacetyl-morphine (heroin) addiction: a medication trial with methadone hydrochloride. JAMA 193: 80-84
11. Downs DA, Miller LE, Wiley JN, Johnston DE (1980) Oral vs parental drug effects on schedule-controlled behavior in rhesus monkeys. Life Sci 26: 1163-1168
12. Fields L, Bruno V, Keller K (1976) The stages of acquisition in stimulus fading. J Exp Anal Behav 26: 295-300
13. Gieske D (1978) Integrated drinking device for monkeys. Reports from the Research Laboratories of the Department of Psychiatry, University of Minnesota, PR-78-1
14. Harrigan SE, Downs DA (1978) Self-administration of heroin, acctylmcthadol, morphine, and methadone in rhesus monkeys. Life Sci 22: 619-624
15. Henningfield JE, Meisch RA (1976) Drinking device for rhesus monkeys. Pharmacol Biochem Behav 4: 609-610
16. Hubbard RL, Marsden ME, Rachel JV, Harwood HJ, Cavanaugh FR, Ginzburg HM (1989) Drug abuse treatment: a national study of effectiveness. University of North Carolina Press, Chapel Hill, N.C.
17. Kreek MJ (1992) Rationale for maintenance pharmacotherapy of opiate dependence. In: O'Brien CP, Jaffe JH (eds) Addictive states. Raven Press, New York, pp 205-230
18. Lemaire GA, Meisch RA (1984) Pentobarbital self-administration in rhesus monkeys: drug concentration and fixed-ratio size interactions. J Exp Anal Behav 42: 37-49
19. Lynch MR, Porter JH, Rosecrans JA (1984) Latent inhibition in the aversion to oral methadone. Pharmacol Biochem Behav 20: 467-472
20. Macenski M, Meisch RA (1992) Ethanol-reinforced responding of naive rhesus monkeys: acquisition without induction procedures. Alcohol 9: 547-554
21. Meisch RA (1995) Oral self-administration of etonitazene in rhesus monkeys: use of a fading procedure to establish etonitazene as a reinforcer. Pharmacol Biochem Behav 50: 571-580
22. Meisch RA, Lemaire GA (1988) Oral self-administration of pentobarbital by rhesus monkeys: relative reinforcing effects under concurrent fixed-ratio schedules. J Exp Anal Behav 50: 75-86
23. Meisch RA, Lemaire GA (1989) Oral self-administration of pentobarbital by rhesus monkeys: maintenance of behavior by different concurrently available volumes of drug solution. J Exp Anal Behav 52: 111-126
24. Meisch RA, Lemaire GA (1993) Drug self-administration. In: Van Haaren F (ed) Methods in behavioral pharmacology. Elsevier, New York, pp 257-300
25. Meisch RA, Kliner DJ, Henningfield JE (1981) Pentobarbital drinking by rhesus monkeys: establishment and maintenance of pentobarbital-reinforced behavior. J Pharmacol Exp Ther 217: 114-120
26. Meisch RA, Bell SM, Lemaire GA (1993) Orally self-administered cocaine in rhesus monkeys: transition from negative or neutral behavioral effects to positive reinforcing effects. Drug Alcohol Depend 32: 143-158
27. Mello NK, Lukas SE, Bree MP, Mendelson JH (1988) Progressive ratio performance maintained by buprenorphine, heroin, and methadone in macaque monkeys. Drug Alcohol Depend 21: 81-97
28. McMillan DE, Leander JD, Wilson TW, Wallace SC, Fix T, Redding S, Turk RT (1976) Oral injestion of narcotic analgesics by rats. J Pharmacol Exp Ther 196: 269-279
29. Moreton JE, Roehs T, Khazan N (1976) Drug self-administration and sleep-awake activity in rats dependent on morphine, methadone, or 1-alpha-acetylmethadol. Psychopharmacology 47: 237-241
30. Samson HH (1986) Initiation of ethanol reinforcement using a sucrose substitution procedure in food- and water-sated rats. Alcohol Clin Exp Res 10: 436-442
31. Schuster CR, Balster RL (1973) Self-administration of agonists. In: Kosterlitz HW, Collier HOJ, Villarreal JE (eds) Agonist and antagonist actions of narcotic analgesic drugs. University Park Press, New York, pp 243-254
32. Schuster CR, Smith BB, Jaffe JH (1971) Drug abuse in heroin users. Arch Gen Psychiatry 24: 359-362
33. Snyder HW, Dustman RH, Straigt RC, Wayne AW, Beck EC (1977) Sudden toxicity of methadone in monkeys: behavioral and electrophysiological evidence. Pharmacol Biochem Bchav 6: 87-92
34. Spiga R, Grabowski J, Silverman PB, Meisch RA (1995) Human methadone self-administration: effects of dose and ratio requirement. Behav Pharmacol (in press)
35. Stewart RB, Lemaire GA, Roache JD, Meisch RA (1994) Establishing benzodiazepines as oral reinforcers: midazolam and diazepam sell-administration in rhesus monkeys. J Pharmacol Exp Ther 271: 200-211
36. Stitzer M, Bigelow G, Liebson I (1979) Supplementary methadone self-administration among methadone maintenance clients. Addict Behav 4: 61-66
37. Stitzer ML, McCaul ME, Bigelow GE, Liebson IA (1983) Oral methadone self-administration: effects of dose and alternative reinforcers. Clin Pharmacol Ther 34: 29-35
38. Tolliver GA, Sadeghi KG, Samson HH (1988) Ethanol preference following the sucrose-fading initiation procedure. Alcohol 5: 9-13
39. Werner TE, Smith SG, Davis WM (1976) A dose-response comparison between methadone and morphine self-administration. Psychopharmacology 74: 209-211
40. Young AM, Swain HH, Woods JH (1981) Comparison of opioid agonists in maintaining responding and in suppressing morphine withdrawal in rhesus monkeys. Psychopharmacology 74: 329-335