Down-regulation of benzodiazepine receptors by ethyl β-carboline-3-carboxylate in cerebrocortical neurons

European Journal of Pharmacology

Volumn 298, Issue 1, 1996, Pages 71-77

  Katsura, Masashi ^a   Ohkuma, Seitaro ^a   Jun, Xu ^a   Kuriyama, Kinya ^a  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

Author keywords

Benzodiazepine receptor; Down regulation; Inverse agonist; Primary cultured neuron; CCE (ethyl carboline 3 carboxylase)

Indexed keywords

BENZODIAZEPINE; BENZODIAZEPINE RECEPTOR; BETA CARBOLINE 3 CARBOXYLIC ACID ETHYL ESTER; FLUMAZENIL; FLUNITRAZEPAM; RADIOLIGAND;

ANIMAL CELL; ARTICLE; BRAIN CORTEX; BRAIN NERVE CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG ANTAGONISM; DRUG RECEPTOR BINDING; FETUS; INTERNALIZATION; MOUSE; NERVE CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; SCATCHARD PLOT;

EID: 0030070872     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(95)00764-4     Document Type: Article

References (30)

1. Chapouthier, G., D. Bondoux, B. Martin, C. Desforges and J.-M. Launay, 1991, Genetic difference in sensitivity to β-carboline: evidence for the involvement of brain benzodiazepine receptors, Brain Res. 553, 342.
2. Chiu, T.H. and H.C. Rosenberg, 1985, Allosteric modulation of flunitrazepam binding to rat brain benzodiazepine receptors by methyl β-carboline-3-carboxylate, J. Neurochem. 44, 306.
3. 2-adrenergic receptor gene in response to short-term agonist exposure, Proc. Natl. Acad. Sci. USA 86, 4853.
4. Distefano, P., K.R. Case, G.D. Colello and H.B. Bossmann, 1979, Increased specific binding of H-diazepam in rat brain following chronic diazepam administration, Cell. Biol. Int. Rep. 3, 163.
5. Fang, Y.-I., M. Iijima, M. Ogawa, T. Suzuki and K. Momose, 1993, Reduction in the numbers of muscarinic receptors by an endogenous protein, Biochem. Pharmacol. 46, 617.
6. Feldman, H.A., 1972, Mathematical theory of complex ligand-binding systems to equilibrium: some methods for parameter fitting, Anal. Biochem. 48, 317.
7. Hadcock, J.R. and C.C. Malbon, 1988, Down-regulation of β-adrenergic receptors: Agonist-induced reduction in receptor mRNA levels, Proc. Natl. Acad. Sci. USA 85, 5021.
8. Harden, T.K., L.A. Petch, S.F. Traynelis and G.L. Walado, 1985, Agonist-induced alteration in the membrane form of muscarinic cholinergic receptors, J. Biol. Chem. 260, 13060.
9. Klein, W.L., J. Sullivan, A. Skorupa and J.S. Aguilar, 1989, Plasticity of neuronal receptors, FASEB J. 3, 2132.
10. Kuriyama, K., S. Tomono, M. Kishi, T. Mukainaka and S. Ohkuma, 1987, Development of γ-aminobutyric acid (GABA)ergic neurons in cerebral cortical neurons in primary culture, Brain Res. 416, 7.
11. Lowry, O.H., N.J. Rosenbrough, A.L. Farr and R.J. Randall, 1951, Protein measurement with the Folin phenol reagent, J. Biol. Chem. 193, 265.
12. Maloteaux, J.-M., K.-N. Octave, A. Gossuin, C. Laterre and A. Trouet, 1987, GABA induces down-regulation of the benzodiazepine-GABA receptor complex in the rat cultured neurons, Eur. J. Pharmacol. 114, 173.
13. Mehta, A.K. and M.K. Ticku, 1992, Chronic GABA exposure down-regulates GABA-benzodtazepine receptor-ionophore complex in cultured cerebral cortical neurons, Mol. Brain. Res. 16, 29
14. Miller, L.G., D.J. Greemblatt, J.G. Barnhill and R.I. Shader, 1988, Chronic benzodiazepine administration. I. Tolerance is associated with benzodiazepine down-regulation and decreased γ-aminobutyric acidA receptor function, J. Pharmacol. Exp. Ther. 246, 170.
15. A receptor function by chronic exposure to GABA-neutral and GABA-negative benzodiazepine ligands in cultured cortical neurons, Biochem. Pharmacol. 40, 1337.
16. Montpied, P., E.I. Ginns, B.M. Martin, D. Roca, D.H. Farb and S.M. Paul, 1991, γ-Aminobutyric acid (GABA) induces a receptor-mediated reduction in GABAA receptor a subunit messenger RNAs in embryonic chick neurons in culture, J. Biol. Chem. 266, 6011.
17. Munson, P.J. and D. Rodbard, 1980, LIGAND: a versatile computerized approach for characterization of ligand-binding system, Anal. Biochem. 107, 220.
18. 2+ influx in mouse cerebral cortical neurons in primary culture, Mol. Brain Res. 27, 145.
19. 3H]MK-801 binding as functional measures, Mol. Brain Res. 22, 166.
20. B receptor, J. Neurochem. 54, 80.
21. Petersen, E.N. and L.H. Jensen, 1984, Proconflict effect of benzodiazepine receptor inverse agonists and other inhibitors of GABA function, Eur. J. Pharmacol. 103, 91.
22. Pole, P., N. Report and D.M. Wright, 1981, Ethyl β-carboline-β-carboxylate antagonizes the action of GABA and benzodiazepines in the hippocampus, Brain Res. 217, 216.
23. Rahman, S. and R.S. Neuman, 1993, Multiple mechanisms of serotonin 5-HT2 receptor desensitization, Eur. J. Pharmacol. 238, 173.
24. 3H-labeled MK-801 binding to the excitatory amino acid receptor complex from rat brain is enhanced by glycine, Proc. Natl. Acad. Sci. USA 84, 7744.
25. Roca, D.J., I. Rozenberg, M. Farrant and D.H. Farb, 1990, Chronic agonist exposure induces down-regulation and allosteric uncoupling of the γ-aminobutyric acid/benzodiazepine receptor complex, Mol. Pharmacol. 37, 37.
26. Rosenberg, H.C. and T.H. Chiu, 1981, Tolerance during chronic benzodiazepine treatment associated with decreased receptor binding, Eur. J. Pharmacol. 70, 453.
27. Shibla, D.B., M.A. Gardell and J.H. Neale, 1981, The insensitivity of developing benzodiazepine receptors to chronic treatment with diazepam. Brain Res. 210, 471.
28. A receptor/benzodiazepine receptor/chloride ion channel complex with ethyl β-carboline-3-carboxylate: presence of independent binding site for ethyl β-carboline-3-carboxylate, J. Pharmacol. Exp. Ther. 253, 558.
29. 2-adrenergic receptor to the stimulatory guanine nucleotide binding protein without interfering with receptor down-regulation, Biochemistry 32, 4979.
30. White, W.F., M.H. Dichter and S.R. Snodgrass, 1981, Benzodiazepine binding and interactions with the GABA receptor complex in living cultures of rat cerebral cortex, Brain Res. 215, 162.