Effects of acute and chronic angiotensin converting enzyme inhibition by spirapril on cardiovascular regulation in essential hypertensive patients. Assessment by spectral analysis and haemodynamic measurements

British Journal of Clinical Pharmacology

Volumn 41, Issue 1, 1996, Pages 49-56

  Veerman, Derk P ^a   Douma, Caroline E ^a   Jacobs, Marie Cecile ^a   Thien, Theo ^a   Van Montfrans, Gert A ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

ACE inhibition; Autonomic nervous system; Blood pressure variability; Hypertension; Orthostasis

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; PLACEBO; SPIRAPRIL;

ADULT; ARTICLE; BLOOD PRESSURE; CARDIOVASCULAR SYSTEM; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; HEART RATE; HEMODYNAMICS; HUMAN; HYPERTENSION; MULTICENTER STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SPECTROSCOPY;

ADULT; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ENALAPRIL; FEMALE; HEMODYNAMIC PROCESSES; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; POSTURE;

EID: 0030069930     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2125.1996.tb00158.x     Document Type: Article

References (46)

1. Williams GH. Converting-Enzyme Inhibitors in the treatment of hypertension. N Engl J Med 1988; 319; 1517-1525.
2. Waeber B, Nussberger J, Brunner HR: Angiotensin-Converting-Enzyme Inhibitors in Hypertension. In Hypertension eds Laragh JH, Brenner BM. Raven Press, New York 1990, pp 2209-2232.
3. Zimmerman BG. Adrenergic facilitation by angiotensin: does it serve a physiological function? Clin Sci 1981; 60: 343-348.
4. Ball SG. The sympathetic nervous system and converting enzyme inhibition. J Cardiovasc Pharmacol 1989; 13(Suppl 3): S17-S21.
5. Sturani A, Chiarini C, Degli Esposti E, Santoro A, Zuccala A, Zuccheli P. Heart rate control in hypertensive patients treated by captopril. Br J Clin Pharmacol 1982; 14: 849-855.
6. Campbell BC, Sturani A, Reid JL. Evidence of parasympathetic activity of the angiotensin converting enzyme inhibitor, captopril, in normotensive man. Clin Sci 1985; 68: 49-56.
7. Philipp T, Sharma AM, Thiede HM, Kribben A. Sympathetic nervous activity and noradrenaline reactivity during angiotensin converting enzyme inhibition. Am J Cardiol 1987; 59: 55D-59D.
8. Warren SE, O'Conner DT, Cohen IM. Autonomic and baroreflex function after captopril in hypertension. Am Heart J 1983; 105: 1002-1008.
9. Giannattasio C, Grassi G, Seravalle G, Morganti A, Zanchetti A, Mancia G. Investigation of reflexes from volume and baroreceptors during converting-enzyme inhibition in humans. Am Heart J 1989; 117: 740-745.
10. Chien Y, Frohlich ED, MacPhee AA, Pegram BL. Quinaprilat increases total body vascular compliance in rats with myocardial infarction. J Cardiovasc Pharmacol 1992; 19: 430-434.
11. Karemaker JM. Analysis of blood pressure and heart rate variability: theoretical considerations and clinical applicability. In Clinical autonomic disorders, ed Lowe PA, Little, Brown and Company, Boston 1993: pp 315-329.
12. Wieling W, Veerman DP, Dambrink JHA, Imholz BPM. Disparities in circulatory adjustment upon standing between young and old subjects explained by pulse contour analysis. Clin Sci 1992; 83: 149-155.
13. Cleland JGF, Dargie HJ, McAlpine H, et al. Severe hypotension after first dose of enalapril in heart failure. Br Med J 1985; 291: 1309-1312.
14. Hodsman GP, Isles CG, Murray GD, Usherwood TP, Webb DJ, Robertson JIS. Factors related to first dose hypotensive effect of captopril: prediction and treatment. Br Med J 1983; 26: 832-834.
15. Vreugdenhil G, van Montfrans GA, Jacobs MC, et al. 24-hour ambulatory blood pressure monitoring with spirapril in mild to severe essential hypertension: a randomized dose comparison. Blood Pressure 1994; 3(Suppl 2): 23-30.
16. Imholz BPM, Wieling W, Langewouters GJ, van Montfrans GA. Continuous finger arterial pressure: utility in the cardiovascular laboratory. Clin Autonom Res 1991; 1: 43-53.
17. Imholz BPM, van Montfrans GA, Settels JJ, van der Hoeven GMA, Karemaker JM, Wieling W. Continuous non-invasive blood pressure monitoring: reliability of Finapres device during the Valsalva manoeuvre. Cardiovasc Res 1988; 22: 390-397.
18. Parati G, Casadei R, Gropelli A, Di Rienzo M, Mancia G. Comparison of finger and intra-arterial blood pressure monitoring at rest and during laboratory testing. Hypertension 1989; 13: 647-655.
19. Wieling W, van Brederode JFM, de Rijk LG, Borst C, Dunning AJ. Reflex control of heart rate in normal subjects in relation to age: a data base for cardiac vagal neuropathy. Diabetologia 1982; 22; 163-166.
20. de Boer RW, Karemaker JM, Strackee J. Relationships between short-term blood pressure fluctuations and heart rate variability in resting subjects 1: a spectral analysis approach. Med Biol Engin Comput 1985; 23: 352-358.
21. de Boer RW, Karemaker JM, Strackee J. Hemodynamic fluctuations and baroreflex sensitivity in humans: a beat-to-beat model. Am J Physiol 1987; 253: H680-H689.
22. Pagani M, Lombardi R, Guzetti S, et al. Power spectral analysis of heart rate and arterial pressure variabilities as a marker of sympatho-vagal interaction in man and conscious dog. Circ Res 1986; 59: 178-193.
23. Wesseling KH, de Wit B, Weber JAP, Smith NT. A simple device for the continuous measurement of cardiac output. Adv Cardiovasc Phys 1983; 5-11: 16-52.
24. Sprangers RLH, Wesseling KH, Imholz ALT, Imholz BPM, Wieling W. Initial blood pressure fall on stand up and exercise explained by changes in total peripheral resistance. J Appl Physiol 1991; 70: 523-30.
25. Jansen JRC, Wesseling KH, Settels JJ, Schreuder JJ. Continuous cardiac output monitoring by pulse contour during cardiac surgery. Eur Heart J 1990; 11(SupplI): 26-32.
26. Julius S. Clinical efficacy and safety. Are different hemodynamic patterns of antihypertensive drugs clinically important? Eur J Clin Pharmacol 1990; 38: S125-S128.
27. Ajayi AA, Campbell BC, Howie CA, Reid JL. Acute and chronic effects of the converting enzyme inhibitors enalapril and lisinopril on reflex control of heart rate in normotensive man. J Hypertension 1985; 3: 47-53.
28. West JNW, Smith SA, Stallard TJ, Littler WA. Effects of Perindopril on ambulatory blood pressure, cardiovascular reflexes and forearm blood flow in essential hypertension. J Hypertension 1989; 7: 97-104.
29. Ajayi AA, Lees KR, Reid JL. Effects of angiotensin converting enzyme inhibitor, perindopril, on autonomic reflexes. Eur J Clin Pharmacol 1986; 30: 177-182.
30. Mancia G, Parati G, Pomidossi G. Modification of arterial baroreflexes by captopril in essential hypertension. Am J Cardiol 1982; 49: 1415-1419.
31. Saul JP, Rea RF, Eckberg DL, Berger RD, Cohen RJ. Heart rate and muscle sympathetic nerve variability during reflex changes of autonomic activity. Am J Physiol 1990; 258: H713-H721.
32. Rimoldi O, Pierini S, Ferrari A, Cerutti S, Paganni M, Malliani A. Analysis of short-term oscillations of R-R and arterial pressure in conscious dogs. Am J Physiol 1990; 258: H967-H976.
33. Di Rienzo M, Parati G, Castiglioni P, et al. Role of sinoaortic afferents in modulating BP and pulse-interval spectral characteristics in unanesthetized cats. Am J Physiol 1991; 261: H1911-H1818.
34. Wesseling KH, Settels JJ, Walstra HG, van Esch HJ, Donders JJH. Baromodulation as the cause of short term blood pressure varibility? In Application of physics to medicine and biology eds Alberi G, Bajzer Z, Baxa P, Singapore: World Scientific, 1983, pp 247-276.
35. Veerman DP, Imholz BPM, Wieling W, Karemaker JM, van Montfrans GA. Effects of ageing on blood pressure varibility in resting conditions. Hypertension 1994; 24: 120-130.
36. Dutrey-Dupagne C, Girard A, Ulmann A, Elghozi JL. Effects of the angiotensin converting enzyme inhibitor trandolapril on short term variability of blood pressure in essential hypertension. Clin Autonom Res 1991; 1: 303-307.
37. Pagani M, Pizzinelli P, Mariani P, Lucini D, di Michele R, Malliani A. Effects of chronic Cilazapril treatment on cardiovascular control: a spectral analytic approach. J Cardiovasc Pharmacol 1992; 19(Suppl 6): S110-116.
38. Uehlinger DE, Ferrier CP, Matthieu R, et al. Antihypertensive contribution of sodium depletion and the sympathetic axis during chronic angiotensin II converting enzyme inhibition. J Hypertension 1989; 7: 901-907.
39. Imai Y, Abe K, Seino M. Captopril attenuates pressor responses to norepinephrine and vasopressin through depletion of endogeneous angiotensin II. Am J Cardiol 1982; 49: 1537-1539.
40. Julius S. Clinical implications of pathophysiologic changes in the midlife hypertensive patient. Am Heart J 1991; 122: 886-891.
41. Johns DW, Baker KM, Ayers CR, Carey RM, Peach MJ. Dilatation of forearm vasculature following angiotensin converting enzyme inhibition by captopril (SQ 14225) in severe hypertension. Circulation 1979; 60(II):II-227.
42. Streeten DHP. Pathogenesis of hyperadrenergic orthostatic hypotension. Evidence of disordered venous innervation exclusively in the lower limbs. J Clin Invest 1990; 86: 1582-1588.
43. Asmussen E, Christensen EH, Nielsen M. The regulation of circulation in different postures. Surgery 1940; 8: 604-616.
44. Ibsen H, Egan B, Osterziel K, Vander A, Julius S. Reflex-hemodynamic adjustments and baroreflex sensitivity during converting enzyme inhibition with MK-421 in normal humans. Hypertension 1983; 5(Suppl I): I-184-I-191.
45. Giannattasio C, Cattaneo BM, Omboni S, et al. Sympathomoderating influence of benazepril in essential hypertension. J Hypertension 1992; 10: 373-378.
46. Morganti A, Grassi G, Giannattasio C, et al. Effects of angiotensin converting enzyme inhibition on cardiovascular regulation during reflex sympathetic activation in sodium-replete patients with essential hypertension. J Hypertension 1989; 7: 825-835.