The cytoplasmic tail of influenza A virus neuraminidase (NA) affects NA incorporation into virions, virion morphology, and virulence in mice but is not essential for virus replication

Journal of Virology

Volumn 70, Issue 2, 1996, Pages 873-879

  Mitnaul, Lyndon J ^a   Castrucci, Maria R ^b   Murti, K Gopal ^a   Kawaoka, Yoshihiro ^a,c  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^c UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS SIALIDASE;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CATTLE; CELL SURFACE; CONTROLLED STUDY; CYTOPLASM; DOG; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; INFLUENZA VIRUS A; MOUSE; NONHUMAN; PRIORITY JOURNAL; VIRION; VIRUS ATTENUATION; VIRUS INFECTIVITY; VIRUS MORPHOLOGY; VIRUS MUTANT; VIRUS PLAQUE; VIRUS REPLICATION; VIRUS VIRULENCE;

EID: 0030069140     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.70.2.873-879.1996     Document Type: Article

References (29)

1. Air, G. M. Personal communication.
2. 1a.Air, G. M., and W. G. Laver. 1989. The neuraminidase of influenza virus. Proteins Struct. Fund. Genet. 6:341-356.
3. Bilsel, P., M. R. Castrucci, and Y. Kawaoka. 1993. Mutations in the cytoplasmic tail of influenza A virus neurarminidase affect incorporation into virions. J Virol 67:5762-6767.
4. Castrucci, M. R., P. Bilsel, and Y. Kawaoka. 1992. Attenuation of influenza A virus by insertion of a foreign epitope into the neuraminidase. J. Virol. 66:4647-4653.
5. Colman, P. M. 1989. Neuraminidase: enzyme and antigen, p. 175-210. In R M. Krug (ed.). The influenza viruses. Plenum Press, New York.
6. Enami, M., W. Lugtjes, M. Krystal, and P. Palese. 1990. Introduction of site-specific mutations into the genome of influenza virus. Proc. Natl. Acad. Sci USA 87:3802-3805
7. Enami, M., and P. Palese. 1991. High-efficiency formation of influenza virus transfectants J Virol. 65:2711-2713
8. Fujiyoshi, Y., N. P. Kume, K. Sakata, and S. B. Sato. 1994. Fine structure of influenza A virus observed by electron cryo-microscopy. EMBO J. 13:318-326.
9. Gaedigk-Nitschko, K., and M. J. Schlesinger. 1991. Site-directed mutations in Sindbis virus E2 glycoprotein's cytoplasmic domain and the 6K protein lead to similar defects in virus assembly and budding. Virology 183:206-214.
10. García-Sastre, A., T. Muster, W. S. Barclay, N. Percy, and P. Palese. 1994. Use of a mammalian internal ribosomal entry site element for expression of a foreign protein by a transfectant influenza virus J. Virol. 68:6254-6262.
11. García-Sastre, A., and P. Palese. 1995. The cytoplasmic tail of the neuraminidase protein of influenza A virus does not play an important role in the packaging of this protein into viral envelopes. Virus Res. 37:37-47.
12. Hoyle, L. 1968. Morphology and physical structure, p. 49-68. In L Hoyle (ed.). The influenza viruses. Springer-Verlag, New York.
13. Jin, H., G. P. Leser, and R. A. Lamb. 1994. The influenza virus hemagglutinin cytoplasmic tail is not essential for virus assembly or infectivity. EMBO J. 13:5504-5515.
14. 12a.Kawaoka, Y. Unpublished data
15. Kunkel, T. A., J. D. Roberts, and R. A. Zakour. 1987. Rapid and efficient site-specific mutagenesis without phenotypic selection. Methods Enzymol. 154:367-382.
16. Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (London) 227:680-685.
17. Lamb, R. A., and P. W. Choppin. 1983. The gene structure and replication of influenza virus. Annu. Rev. Biochem 52:467-506.
18. Liu, C., and G. M. Air. 1993. Selection and characterization of a neuraminidase minus mutant of influenza virus and its rescue by cloned neuraminidase genes. Virology 194:403-407.
19. Liu, C., M. C. Eichelberger, R. W. Compans, and G. M. Air. 1995. Influenza type A virus neuraminidase does not play a role in virus entry, replication, assembly, or budding. J. Virol. 69:1099-1106.
20. Miki, T., Y. Nishida, H. Hisajima, M. Takashi, Y. Kumahara, K. Nerome, A. Oya, T. Fukui, E. Ohtsuka, M. Ikehara, and T. Honjo. 1983. The complete nucleotide sequence of the influenza virus neuraminidase gene of A/NJ/8/76 strain and its evolution by segmental duplication and deletion. Mol. Biol. Med. 1:401-413.
21. Murti, K. G., W. J. Bean, Jr., and R. G. Webster. 1980. Helical ribonucleoproteins of influenza virus, an electron microscopic study. Virology 104:224-229.
22. Naim, H. Y., and M. Roth. 1993. Basis for selective incorporation of glycoproteins into the influenza virus envelope. J. Virol. 67:4831-4841.
23. Palese, P., K. Tobita, M. Ueda, and R. W. Compans. 1974. Characterization of temperature sensitive influenza virus mutants defective in neuraminidase. Virology 61:397-410.
24. Parvin, J. D., P. Palese, A. Honda, A. Ishihama, and M. Krystal. 1989. Promoter analysis of influenza virus RNA polymerase. J. Virol. 63:5142-5152.
25. Percy, N., W. S. Barclay, A. García-Sastre, and P. Palese. 1994. Expression of a foreign protein by influenza A virus. J. Virol. 68:4486-4492
26. Smirnov, Y. A., M. A. Kuznetsova, and N. V. Kaverin. 1991. The genetic aspects of influenza virus filamentous particle formation. Arch. Virol. 118:279-284.
27. Sugiura, A., and M. Ueda. 1980. Neurovirulence of influenza virus in mice. I Neurovirulence of recombinants between virulent and avirulent virus strains. Virology 101:440-449
28. Warner, T. G., and J. S. O'Brien. 1979. Synthesis of 2′-(4-methylumbelliferyl)-α-D-N-acetylneurammic acid and detection of skin fibroblast neuraminidase in normal humans and in sialidosis. Biochemistry 18:2783-2787.
29. Whitt, M. A., L. Chong, and J. K. Rose. 1989. Glycoprotein cytoplasmic domain sequences required for rescue of a vesicular stomatitis virus glycoprotein mutant. J Virol 63:3569-3578.