Facile synthesis of pyrazino[2,3-e][1,4]diazepine derivatives via the intramolecular aza-Wittig reaction

Tetrahedron Letters

Volumn 37, Issue 1, 1996, Pages 81-84

  Okawa, Tomohiro ^a   Eguchi, Shoji ^a  

^a NAGOYA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DIAZEPINE DERIVATIVE; PYRAZINE DERIVATIVE; PYRAZINO[2,3 E][1,4]DIAZEPINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; REACTION ANALYSIS;

EID: 0030068875     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/0040-4039(95)02107-8     Document Type: Article

References (30)

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25. We thank Shiratori Pharmaceutical Co., Ltd. for a gift of DMC.
26. Iminophosphorane 3 was isolable after flash chromatography on silica gel column; however, it was hygroscopic and hydrolyzed gradually to the starting amide 2.
27. These new compounds had satisfactory spectral and analytical data for the given structures. The assigned stereochemistry was based on the fact that no racemization was found to occur during the condensation with use of DEPC (ref. 11) and the intramolecular aza-Wittig reaction (ref. 5).
28. 3, s).
29. 3, 200MHz) signal at δ 9.73 (1H, NHCO, br).
30. 2, respectively.