Hypoglycemic hyperemia in retina of newborn pigs: Involvement of adenosine

Investigative Ophthalmology and Visual Science

Volumn 37, Issue 1, 1996, Pages 86-92

  Zhu, Yun ^a   Gidday, Jeffrey M ^a,b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ST LOUIS CHILDREN S HOSPITAL   (United States)

Author keywords

8 phenyltheophylline; adenosine; angiography; fluorescein swine; hypoglycemia; neonate; retinal blood flow

Indexed keywords

8 PHENYLTHEOPHYLLINE; ADENOSINE; ADENOSINE RECEPTOR BLOCKING AGENT; FLUORESCEIN SODIUM; GLUCOSE; INSULIN;

ANIMAL MODEL; ARTICLE; BLOOD VESSEL DIAMETER; CONTROLLED STUDY; FLUORESCENCE ANGIOGRAPHY; GLUCOSE BLOOD LEVEL; HEMODYNAMIC PARAMETERS; HYPEREMIA; HYPOGLYCEMIA; IMAGE ANALYSIS; NEWBORN; NEWBORN DISEASE; NONHUMAN; PRIORITY JOURNAL; RETINA BLOOD FLOW; SWINE; VASODILATATION;

ADENOSINE; ANIMALS; ANIMALS, NEWBORN; BLOOD GLUCOSE; BLOOD PRESSURE; FLUORESCEIN ANGIOGRAPHY; HYPEREMIA; HYPOGLYCEMIA; IMAGE PROCESSING, COMPUTER-ASSISTED; INJECTIONS, INTRAVENOUS; INSULIN; RANDOM ALLOCATION; RECEPTORS, PURINERGIC P1; REGIONAL BLOOD FLOW; RETINAL VESSELS; SWINE; THEOPHYLLINE; VIDEO RECORDING;

EID: 0030068848     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Sann L. Neonatal hypoglycemia. Biol Neonate. 1990;58(suppl1):16-21.
2. Pides RS, Lilien LD. Metabolic and endocrine disorders. In: Fanaroff AA, Martin RJ, eds. Neonatal-Perinatal Medicine. CV Mosby: St. Louis; 1992:1152-1180.
3. Cringle SJ, Yu D-Y, Alder VA, Su E-R. Retinal blood flow by hydrogen clearance polarography in the streptozotocin-induced diabetic rat. Invest Ophthalmol Vis Sci. 1993; 34:1716-1721.
4. Grunwald JE, Bruckner AJ, Grunwald SE, Riva CE. Retinal hemodynamics in proliferative diabetic retinopathy. Invest Ophthalmol Vis Sci. 1993; 3466-3471.
5. Sullivan PM, Davies GE, Caldwell G, Morris AC, Kohner EM. Retinal blood flow during hyperglycemia. Invest Ophthalmol Vis Sci. 1990; 31:2041-2045.
6. Caldwell G, Davies EG, Sullivan PM, Morris AH, Kohner EM. A laser Doppler velocimetry study of the effect of hypoglycaemia on retinal blood flow in the minipig. Diabetologia. 1990;33:262-265.
7. Vannucci RC, Nardis EE, Vannucci SJ, Campbell PA. Cerebral carbohydrate and energy metabolism during hypoglycemia in newborn dogs. Am J Physiol. 1981;240:R192-R199.
8. Gardiner RM. The effects of hypoglycaemia on cerebral blood flow and metabolism in the new-born calf. J Physiol. (Lond). 1980; 298:37-51.
9. Hernandez MJ, Brennan RW, Bowman GS. Autoregulation of cerebral blood flow in the newborn dog. Brain Res. 1980; 184:199-202.
10. Anwar M, Vannucci RC. Autoradiographic determination of regional cerebral blood flow during hypoglycemia in newborn dogs. Pediatr Res. 1988; 24:41-45.
11. Mujsce DJ, Christensen MA, Vannucci RC. Regional cerebral blood flow and glucose utilization during hypoglycemia in newborn dogs. Am J Physiol. 1989; 256:H1659-H1666.
12. Ruth VJ, Park TS, Gonzales ER, Gidday JM. Adenosine and cerebrovascular hyperemia during insulin-induced hypoglycemia in newborn piglet. Am J Physiol. 1993; 265:H1762-H1768.
13. Rootman J. Vascular system of the optic nerve head and retina of the pig. Br J Ophthalmol. 1971; 55:808-819.
14. Rovainen CM, Woolsey TA, Blocher NC, Wang D-B, Robinson OF. Blood flow in single surface arterioles and venules on the mouse somatosensory cortex measured with videomicroscopy, fluorescent dextrans, nonoccluding fluorescent beads, and computer-assisted image analysis. J Cereb Blood Flow Metab. 1993; 13:359-371.
15. Bulpitt CJ, Dollery CT. Estimation of retinal blood flow by measurement of the mean circulation time. Cardiovasc Res. 1971; 5:406-412.
16. Skrandies W, Heinrich H. Differential effects of mild hypoglycemia on proximal and distal retinal structures in man as revealed by electroretinography. Neurosci Lett. 1992; 134:165-168.
17. Siesjö BK. Hypoglycemia, brain metabolism, and brain damage. Diabetes Metab Rev. 1988; 4:113-144.
18. Wieloch T. Hypoglycemia-induced neuronal damage prevented by an N-methyl-D-aspartate antagonist. Science. 1985; 230:681-683.
19. Siesjö BK, Ingvar M, Pelligrino DA. Regional differences in vascular autoregulation in the rat brain in severe insulin-induced hypoglycemia. J Cereb Blood Flow Metab. 1983; 3:478-485.
20. Park TS, Gonzales ER, Shah AR, Gidday JM. Hypoglycemia selectively abolishes hypoxic reactivity of pial arterioles in piglets: Role of adenosine. Am J Physiol. 1995; 268:H871-H878.
21. 2 on relative retinal blood flow in monkeys. Invest Ophthalmol Vis Sci. 1975; 14:342-352.
22. Milley JR, Rosenberg AA, Jones MD Jr. Retinal and choroidal blood flows in hypoxic and hypercarbic newborn lambs. Pediatr Res. 1984; 18:410-414.
23. Fallon TJ, Maxwell DL, Kohner EM. Autoregulation of retinal blood flow in diabetic retinopathy measured by the blue-light entoptic technique. Ophthalmology. 1987;94:1410-1415.
24. Winkler BS. Glycolytic and oxidative metabolism in relation to retinal function. J Gen Physiol. 1981 ; 77:667-692.
25. Weiss H. The carbohydrate reserve in the vitreous body and retina of the rabbit's eye during and after pressure ischemia and insulin hypoglycaemia. Ophthalmol Res. 1972; 3:360-371.
26. Gidday JM, Park TS. Microcirculatory responses to adenosine in the newborn pig retina. Pediatr Res. 1993; 33:620-627.
27. Braunagel SC, Xiao JG, Chiou GCY. The potential role of adenosine in regulating blood flow in the eye. J Ocul Pharmacol. 1988; 4:61-73.
28. Campochiaro PA, Sen HA. Adenosine and its agonists cause retinal vasodilation and hemorrhages: Implications for ischemic retinopathies. Arch Ophthalmol. 1989; 107:412-416.
29. Portellos M, Riva CE, Cranstoun SD, Petrig BL, Brucker AJ. Effects of adenosine on ocular blood flow. Invest Ophthalmol Vis Sci. 1995; 36:1904-1909.
30. Gidday JM, Park TS. Adenosine-mediated autoregulation of retinal arteriolar tone in the piglet. Invest Ophthalmol Vis Sci. 1993;34:2713-2719.
31. Griffith SG, Meghji P, Moody CJ, Burnstock G. 8-phenyltheophylline: A potent Pl-purinoceptor antagonist. Eur J Pharmacol. 1981; 75:61-64.
32. Roth S, Nunez R, Pietrzyk Z. Adenosine antagonism attenuates hypoxia-induced vasodilation in the retina in cats. Anesth Analg. 1993; 76:S358. Abstract.
33. Laudignon N, Farri E, Beharry K, Rex J, Aranda JV. Influence of adenosine on cerebral blood flow during hypoxic hypoxia in the newborn piglet. J Appl Physiol. 1990; 68:1534-1541.
34. 3H]Glycogen hydrolysis elicited by adenosine in rabbit retina: Involvement of A2 receptors. Neurochem Int. 1989; 14:419-422