Radiation induced DNA damage and damage repair in three human tumour cell lines

Mutation Research - DNA Repair

Volumn 362, Issue 1, 1996, Pages 51-59

  Woudstra, Elies C ^a   Brunsting, Jeanette F ^a   Roesink, Judith M ^a   Konings, Antonius W T ^a   Kampinga, Harm H ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

Alkaline unwinding; CHEF; Chromatin structure; DNA strand breaks; Pulsed field gel electrophoresis; Radiation sensitivity

Indexed keywords

ARTICLE; CHROMATIN STRUCTURE; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DNA STRAND BREAKAGE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PULSED FIELD GEL ELECTROPHORESIS; RADIATION; RADIOSENSITIVITY; TUMOR CELL LINE;

EID: 0030068626     PISSN: 09218777     EISSN: None     Source Type: Journal    
DOI: 10.1016/0921-8777(95)00032-1     Document Type: Article

References (27)

1. Ahnström, G. and Edvardsson, K-A. (1974) Radiation-induced single-strand breaks in DNA determined by rate of alkaline strand separation and hydroxylapatite chromatography: an alternative to velocity sedimentation. Int. J. Radiat. Biol., 26, 493-497.
2. Biedermann, K., Sun, J., Giaccia, A., Tosto, L. and Brown J.M. (1991) The scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double strand break repair, Proc. Natl. Acad. Sci. USA, 88, 1394-1397.
3. Blöcher, D., Einspenner, M., Zajackowski, J. (1989) CHEF electrophoresis, a sensitive technique for the determination of DNA double strand breaks. Int. J. Radiat. Biol., 56, 437-448.
4. Dahm-Daphi, J., Dikomey, E., Pyttlik, C. and Jeggo, P.A. (1993) Reparable and non-reparable DNA strand breaks induced by X-irradiation in CHO K1 cells and the radiosensitive mutants xrs1 and xrs5, Int. J. Radiat. Biol., 64, 19-26.
5. Deacon, J.M., Peckham, M.J. and Steel, G.G. (1984) The radioresponsiveness of human tumours and the initial slope of the cell survival curve, Radiother. Oncol., 2, 317-323.
6. Frankenberg-Schwager, M. (1989) Review of repair kinetics for DNA damage induced in eukaryotic cells in vitro by ionizing radiation, Radiother. Oncol., 14, 307-320.
7. George, A.M. and Cramp, W.A. (1987) The effects of ionizing radiation on structure and function of DNA, Prog. Biophys. Mol. Biol., 50, 121-169.
8. Jorgensen, T.J., Prasad, S.C., Brennan, T.P. and Dritschilo, A. (1990) Constraints to DNA unwinding near radiation-induced strand breaks in Ewing's sarcoma cells, Radiation Res., 123, 320-324.
9. Kelland, L.R., Edwards, S.M. and Steel, G.G. (1988) Induction and rejoining of DNA double-strand breaks in human cervix carcinoma cell lines of differing radiosensitivity, Radiation Res., 116, 526-538.
10. Kemp, L.M., Sedgwick, S.G. and Jeggo, P.A. (1984) X-ray sensitive mutant of Chinese hamster ovary cells defective in double-strand break rejoining, Mutation Res., 132, 189-196.
11. Lavin, M.F. and Schroeder, A.L. (1988) Damage-resistant DNA synthesis in eukaryotes. Mutation Res., 193, 193-206.
12. Ljungman, M. (1991) The influence of chromatin structure on the frequency of radiation-induced DNA strand breaks: a study using nuclear and nucleoid monolayers, Radiation Res., 126, 58-64.
13. McMillan, T.J., Cassoni, A.M., Edwards, S., Holmes, A. and Peacock, J.H. (1990) The relationship of DNA double-strand break induction to radiosensitivity in human tumour cell lines, Int. J. Radiat. Biol., 58, 427-438.
14. Olive, P.L., Hilton, J. and Durand, R.E. (1986) DNA conformation of Chinese Hamster V79 cells and sensitivity to ionizing radiation. Radiation Res., 107, 115-124.
15. Olive, P.L., Banath, J.P. and MacPhail, H.S. (1994) Lack of a correlation between radiosensitivity and DNA double-strand break induction or rejoining in six human tumor cell lines, Cancer Res., 54, 3939-3946.
16. Peacock, J.H., Eady, J.J., Edwards, S., Holmes, A., McMillan, T.J. and Steel, G.G. (1989) Initial damage or repair as the major determinant of cellular radiosensitivity, Int. J. Radiat. Biol., 56, 543-547.
17. Powell, S.N. and McMillan, T.J. (1994) The repair fidelity of restriction enzyme-induced double strand breaks in plasmid DNA correlates with radioresistance in human tumor cell lines, Int. J. Radiation Oncol. Biol. Phys., 29, 1035-1040.
18. Radford, I.R. (1986) Evidence for a general relationship between the induced level of DNA double-strand breakage and cell-killing after X-irradiation of mammalian cells. Int. J. Radiat. Biol., 49, 611-620.
19. Rosemann, M., Kanon, B., Konings, A.W.T. and Kampinga, H.H. (1993) An image analysis technique for the detection of radiation-induced DNA fragmentation after CHEF electrophoresis, Int. J. Radiat. Biol., 64, 245-249.
20. Schwartz, J.L., Moan, E., Mustafi, R., Fink, L. and Yasui, L.S. (1992) Faster rates of DNA unwinding under alkaline conditions in xrs-5 cells may reflect chromatin structure alterations. Mutation Res., 282, 13-17.
21. Smeets, M.F.M., Mooren, E.H.M. and Begg, A.C. (1993) Radiation-induced DNA damage and repair in radiosensitive and radioresistant human tumour cells measured by field inversion gel electrophoresis. Int. J. Radiat. Biol., 63. 703-713.
22. Smider, V., Rathmell, W.K., Lieber, M.R. and Chu, G. (1994) Restoration of X-ray resistance and V(D)J recombination in mutant cells by Ku cDNA, Science, 266, 288-291.
23. Taccioli, G.H., Gottlieb, T.M., Blunt, T., Priestley, A., Demengeot, J., Mizuta, R., Lehmann, A.R., Alt, F.W., Jackson, S.P. and Jeggo, P. A. (1994) Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination, Science, 265, 1442-445.
24. Thompson, L.H., Brookman, K.W., Jones, N.J., Allen, S.A., Carrano, A.V. (1990) Molecular cloning of the human XRCC1 gene, which corrects defective DNA strand break repair and sister chromatid exchange, Mol. Cell. Biol. 10, 6160-6171.
25. Troelstra, C. and Jaspers, N.G.J. (1994) Ku starts at the end, Current Biology, 4, 1149-1151.
26. Ward, J.F. (1990) The yield of DNA double-strand breaks produced intracellularly by ionizing radiation: a review, Int. J. Radiat. Biol., 57, 1141-1150.
27. Whitaker, S.J., Ung, Y.C. and McMillan, T.J. (1995) DNA double-strand break induction and rejoining as determinants of human tumour cell radiosensitivity, A pulsed-field gel electrophoresis study. Int. J. Radiat. Biol., 67. 7-18.