Bcl-2 distribution in neuroepithelial tumors: An immunohistochemical study

Journal of Neuro-Oncology

Volumn 27, Issue 2, 1996, Pages 101-109

  Schiffer, D ^a  

^a UNIVERSITY OF TURIN   (Italy)

Author keywords

bcl 2; Neuroepithelial tumors; p53

Indexed keywords

PROTEIN BCL 2; PROTEIN P53;

APOPTOSIS; ARTICLE; ASTROCYTE; ASTROCYTOMA; BRAIN TUMOR; CELL MEMBRANE; CELL SURVIVAL; CONTROLLED STUDY; EPENDYMOMA; GENE EXPRESSION; GLIOBLASTOMA; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LYMPHOMA; MAJOR CLINICAL STUDY; MEDULLOBLASTOMA; MITOCHONDRIAL MEMBRANE; NEUROEPITHELIOMA; OLIGODENDROGLIA; PAPILLOMA; PROTEIN LOCALIZATION; PROTO ONCOGENE; TUMOR CELL;

EID: 0030068560     PISSN: 0167594X     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00177472     Document Type: Article

References (27)

1. McCarthy NJ, Smith CA, Williams GT: Apoptosis in the development of the immune system: growth factors, clonal selection and bcl-2. Cancer Metastasis Rev 11:157-178, 1992
2. Oren M: The involvement of oncogenes and tumor suppressor genes in the control of apoptosis. Cancer Metastasis Rev 11: 141-148, 1992
3. Kondo E, Nakamura S, Onoue H, Matsuo Y, Yoshino T, Aoki H, Hayashi K, Takahashi K, Nomura S, Akagi T: Detection of bcl-2 protein and bcl-2 messenger RNA in normal and neoplastic lymphoid tissues by immunohistochemistry and in situ hybridization. Blood 80: 2044-2051, 1992
4. Wyllie AH: Apoptosis (The Frank Rose Memorial Lecture). Br J Cancer 67: 205-208, 1993
5. de Jong D, Prins FA, Mason DY, Reed JC, van Ommen GB, Kluin PM: Subcellular localization of the bcl-2 protein in malignant and normal lymphoid cells. Cancer Res 54: 256-260, 1994
6. Hockenbery DM, Zutter M, Hickey W, Nahm M, Korstmeyer SJ: BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proc Natl Acad Sci USA 88: 6961-6965, 1991
7. Willingham MC, Bhalla K: Transient mitotic phase localization of bcl-2 oncoprotein in human carcinoma cells and its possible role in prevention of apoptosis. J Histochem Cytochem 42 : 441-450, 1994
8. Lu QL, Poulsom R, Wong L, Hanby AM: Bcl-2 expression in adult and embryonic non-haematopoietic tissues. J Pathol 169: 431-437, 1993
9. Alderson LM, Castleberg LL, Harsh IV GR, Louis DN, Henson JW: Human gliomas with wild-type p53 express bcl-2. Cancer Res 55: 999-1001, 1995
10. Wang Y, Szekely I, Okan I, Klein G, Wiman KG: Wild-type p53 triggered apoptosis is inhibited by bcl-2 in a v-myc induced T-cell lymphoma line. Oncogene 8: 3427-3431, 1993
11. Reed JV, Meister L, Tanaka S, Cuddy M, Yum S, Geyer C, Pleasure D: Differential expression of bcl-2 protooncogene in neuroblastoma and other human tumor cell lines of neural origin. Cancer Res 51: 6529-6538, 1991
12. Castle VP, Heidelberger KP, Bromber J, Ou X, Dole M, Nunez G: Expression of the apoptosis-suppressing protein bcl-2, in neuroblastoma is associated with unfavorable histology and N-myc amplification. Am J Pathol 143: 1543-1550, 1993
13. Ramani P, Lu QL: Expression of bcl-2 gene product in neuroblastoma. J Pathol 172: 273-278, 1994
14. Nakasu S, Nakasu Y, Nioka H, Nakajima M, Handa J: bcl-2 protein expression in tumors of the central nervous system. Acta Neuropathol 88: 520-526, 1994
15. Kaplan EL, Meier P: Non parametric estimation from incomplete observations. J Am Stat Assoc 53: 457-481, 1958
16. Peto R, Pike MG, Armitage P, Breslow NE, Cox DR, Howard SB, Mantel N, McPherson K, Peto J, Smith PG: Design and analysis of randomized clinical trials requiring prolonged observations of each patient: Analysis and examples. Br J Cancer 35: 1-39, 1977
17. 4. Nature 227: 680-685, 1970
18. Towbin H, Staehelin T, Gordon J: Electrophoretic transfer of proteins from polyaerylamide gels to nitrocellulose: procedure and some applications. Proc Natl Acad Sci USA 76: 4350-5354, 1979
19. Migheli A, Cavalla P, Giordana MT, Schiffer D: BCL-2 protein expression in aged brain and neurodegenerative disease. Neuro Report 5: 1406-1408, 1994
20. Hockenbery DM, Oltvai ZN, Ying XM, Milliman CL, Korsmeyer SJ: Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 75: 241-251, 1993
21. Goldfarb DS: Are the cytosolic components of the nuclear, ER and mitochondrial import apparatus functionally related? Cell 70: 185-188, 1992
22. Wagner AJ, Small MB, Hay N: Myc-mediated apoptosis is blocked by ectopic expression of bcl-2. Mol Cell Biol 4: 2432-2440, 1993
23. Alnemri ES, Fernandes TF, Haldar S, Croce CM, Litwack G: Involvement of bcl-2 in glucocorticoid-induced apoptosis of human pre-B-leukemias. Cancer Res 52: 491-495, 1992
24. Kane DJ, Sarafian TA, Anton R, Hanh H, Butler Gralla E, Valentine GS, Ord T, Bredesen DE: Bcl-2 prevention of neural death: decreased generation of reactive oxigen species. Science 262: 1274-1277, 1993
25. Schiffer D, Cavalla P, Chiò A, Giordana MT, Marino S, Mauro A, Migheli A: Tumor cell proliferation and apoptosis in medulloblastoma. Acta Neuropathol 87: 363-370, 1994
26. Hockenbery D, Nunez G, Milliman C, Schreiber RD, Korsmeyer SJ: Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 348: 334-336, 1990
27. Lithgow T, Vandriel R, Bertram JF, Strasser A: The protein product of the oncogene Bcl-2 is a component of the nuclear envelope, the endoplasmic reticulum and the outer mitochondrial membrane. Cell Growth Differ 5: 411-417, 1994