Partial reversal of increased preproenkephalin messenger ribonucleic acid (mRNA) and decreased preprotachykinin mRNA by foetal dopamine cells in unilateral 6-hydroxydopamine-lesioned rat striatum parallels functional recovery

Movement Disorders

Volumn 11, Issue 1, 1996, Pages 43-52

  Zeng, B Y ^a   Jenner, P ^a   Marsden, C D ^b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

6 Hydroxydopamine lesion; Foetal dopamine neurone graft; Preproenkephalin messenger ribonucleic acid; Preprotachykinin messenger ribonucleic acid

Indexed keywords

DOPAMINE DERIVATIVE; MESSENGER RNA; PREPROTACHYKININ;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN FUNCTION; CONTROLLED STUDY; CORPUS STRIATUM; DEAFFERENTATION; DOPAMINERGIC NERVE CELL; FETUS CELL; IN SITU HYBRIDIZATION; MESENCEPHALON; NERVE DEGENERATION; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; RAT;

ANIMALS; BRAIN TISSUE TRANSPLANTATION; CORPUS STRIATUM; DOMINANCE, CEREBRAL; DOPAMINE; ENKEPHALINS; FEMALE; FETAL TISSUE TRANSPLANTATION; GENE EXPRESSION; MALE; MESENCEPHALON; NERVE REGENERATION; OXIDOPAMINE; PROTEIN PRECURSORS; RATS; RATS, WISTAR; RNA, MESSENGER; STEREOTYPED BEHAVIOR; SUBSTANTIA NIGRA; TACHYKININS;

EID: 0030068163     PISSN: 08853185     EISSN: None     Source Type: Journal    
DOI: 10.1002/mds.870110109     Document Type: Article

References (45)

1. Dunnett SB, Bjorklund A, Stenevi U, Iversen SD. Behavioural recovery following transplantation of substantia nigra in rats subjected to 6-OHDA lesions of the nigrostriatal pathway. I. Unilateral lesions. Brain Res 1981;215:147-161.
2. Dunnett SB, Bjorklund A, Schmidt RH, Stenevi U, Iversen SD. Intracerebral grafting of neuronal suspensions. IV. Behavioural recovery in rats with unilateral 6-OHDA lesions following implantation of nigral cell suspensions in different forebrain sites. Acta Physiol Scand 1983;522:29-37.
3. Strecker RE, Sharp T, Brundin P, Zetterström T, Björklund A. Autoregulation of dopamine release and metabolism by intrastrital nigral grafts as revealed by intracerebral dialysis. Neuroscience 1987;22:169-178.
4. Douget G, Murata Y, Brundin P, et al. Host afferents into intrastriatal transplants of fetal ventral mesencephalon. Exp Neurol 1989;106:1-19.
5. Freund TF, Bolam JP, Bjorklund A, et al. Efferent synaptic connections of grafted dopaminergic neurons reinnervating the host neostriatum: a tyrosine hydroxylase immunocytochemical study. J Neurosci 1985;5:603-616.
6. Dawson TM, Dawson VL, Gage FH, Fisher LJ, Hunt MA, Wamsley JK. Functional recovery of supersensitive dopamine receptors after intrastriatal grafts of fetal substantia nigra. Exp Neurol 1991;111:282-292.
7. Savasta M, Mennicken F, Chritin M, et al. Intrastrial dopamine rich implants reverse the changes in dopamine D2 receptor densities caused by 6-OHDA lesion of the nigrostriatal pathway in rats: an autoradiographic study. Neuroscience 1992;46:729-738.
8. Albin RL, Young AB, Penney JB. The functional anatomy of basal ganglia disorders. Trends Neurosci 1989;12:366-375.
9. Bjorklund A, Lindvall O. Catecholaminergic brain stem regulatory system. In: Bloom FE, ed. Handbook of physiology - the nervous system, IV. Bethesda: American Physiological Society, 1986:115-235.
10. Graybiel AM. Neurotransmitters and neuromodulators in the basal ganglia. Trends Neurosci 1990;13:244-253.
11. Graybiel AM, Ragsdale CW Jr. Biochemical anatomy of the striatum. In: Emson PC, ed. Chemical neuroanatomy. New York: Raven Press, 1989:427-504.
12. Reiner A, Anderson KD. The patterns of neurotransmitter and neuropeptide co-occurrence among striatal projection neurons: conclusions based on recent findings. Brain Res Rev 1990;15:251-265.
13. Sivam SP, Breese GR, Krause JE, Napier TC, Mueller RA, Hong JS. Neonatal and adult 6-hydroxydopamine-induced lesions differentially alter tachykinin and enkephalin gene expression. J Neurochem 1987;49:1623-1633.
14. Voorn P, Roest G, Groenewegen HJ. Increase of enkephalin and decrease of substance P immunoreactivity in the dorsal and ventral striatum of the rat after midbrain 6-hydroxydopamine lesions. Brain Res 1987;412:391-398.
15. Brene S, Lindefors N, Persson H. Midbrain dopamine neurons regulated preprotachykinin - A mRNA expression in the rat forebrain during development. Mol Brain Res 1992;14: 13-19.
16. Cadet JL, Zhu SM, Angulo JA. Quantitative in situ hybridization evidence for differential regulation of proenkephalin and dopamine D2 receptor mRNA levels in the rat striatum: effects of unilateral intrastriatal injections of 6-hydroxydopamine. Mol Brain Res 1992;12:59-67.
17. Gerfen CR, Engber TM, Susel Z, et al. D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons Science 1990;250:1429-1432.
18. Vernier P, Julien JF, Rataboul P, Fourrier O, Feuerstein C, Mallet J. Similar time course changes in striatal levels of glutamic acid decarboxylase and proenkephalin mRNA following dopaminergic deafferentation in the rat. J Neurochem 1988;51:1375-1380.
19. Manier M, Abrous DN, Feuerstein C, Le Moal M, Herman JP. Increase of striatal methionine enkephalin content following lesion of the nigrostriatal dopaminergic pathway in adult rats and reversal following the implantation of embryonic dopaminergic neurons: a quantitative immunohistochemical analysis. Neuroscience 1991;42:427-439.
20. Bal A, Savasta M, Chritin M, et al. Transplantation of fetal nigral cells reverses the increase of preproenkephalin mRNA levels in the rat striatum caused by 6-OHDA lesion of the dopaminergic nigrostriatal pathway: a quantitative in situ hybridization study. Mol Brain Res 1992;18:221-227.
21. Mendez IM, Naus CCG, Eliseich K, Flumerfelt BA. Normalization of striatal proenkephalin and preprotachykinin mRNA expression by fetal substantia nigra grafts. Exp Neurol 1993;119:1-10.
22. Cenci MA, Campbell K, Bjorklund A. Neuropeptide messenger RNA expression in the 6-hydroxydopamine-lesioned rat striatum reinnervated by fetal dopaminergic transplants: differential effects of the grafts on preproenkephalin, preprotachykinin and prodynorphin messenger RNA levels. Neuroscience 1993;57:275-296.
23. Zeng BY, Jolkkonen J, Jenner P, Marsden CD. Chronic L-DOPA treatment differentially regulates gene expression of glutamic acid decarboxylase, preproenkephalin and preprotachykinin in the striatum of 6-hydroxydopamine-lesioned rat. Neuroscience 1995;66:19-28.
24. Pellegrino LJ, Pellegrino AS, Cushman AJ. A stereotaxic atlas of the rat brain. 2nd ed. New York: Plenum Press, 1979.
25. Bjorklund A, Stenevi U, Schmidt RH, Dunnett SB, Gage FH. Intracerebral grafting of neuronal cell suspensions I. Introduction and general methods of preparation. Acta Physiol Scand 1983;522:1-8.
26. Bjorklund A, Dunnett SB, Stenevi U, Lewis ME, Iversen SD. Reinnervation of the denervated striatum by substantia nigra transplants: functional consequences as revealed by pharmacological and sensorimotor testing. Brain Res 1980; 199:307-333.
27. Brundin P, Isacson O, Gage FH, Prochiants A, Bjorklund A. The rotating 6-hydroxy-dopamine-lesioned mouse as a model for assessing functional effects of neuronal grafting. Brain Res 1986;366:346-349.
28. Dunnett SB, Whishaw IQ, Rogers DC, Jones GH. Dopamine-rich grafts ameliorate whole body motor asymmetry and sensory neglect but not independent limb use in rats with 6-hydroxydopamine lesions. Brain Res 1987;415:63-78.
29. Young III WS, Bonner TI, Brann MR. Mesencephalic dopamine neurons regulate the expression of neuropeptide mRNAs in the rat forebrain. Proc Natl Acad Sci USA 1986; 83:9827-9831.
30. Cadet JL, Zhu SM, Angulo JA. Intrastriatal implants of fetal mesencephalic cells attenuate the increases in striatal proenkephalin mRNA observed after unilateral 6-hydroxydopamine-induced lesions of the striatum. Brain Res Bull 1991;27: 707-711.
31. Vandermaelen CP, Koscis JD, Kitai ST. Caudate afferents from the retrorubral nucleus and other midbrain areas in the cat. Brain Res Bull 1978;3:639-644.
32. Zabo J. Distribution of striatal afferents from the mesencephalon in the cat. Brain Res 1980;188:3-21.
33. Cadet JL, Angulo JA, McEwen BS. Nerve growth factor (NGF) potentates the changes in striatal proenkephalin mR-NAs subsequent to 6-hydroxydopamine-induced lesions of the substantia nigra. Brain Res Bull 1990;25:401-405.
34. Sirinathsinghji DJS, Dunnett SB. Increased proenkephalin mRNA levels in the rat neostriatum following lesion of the ipsilateral nigrostriatal dopamine pathway with 1-methyl-4-phenylpy-ridinium ion (MPP+): reversal by embryonic nigral dopamine grafts. Mol Brain Res 1991;9:263-269.
35. Abrous N, Guy J, Vigny A, Calas A, Le Moal M, Herman JP. Development of intracerebral dopaminergic grafts: a combined immunohistochemical and autoradiographic study of its time course and environmental influences. J Comp Neurol 1988;273:26-41.
36. Herman JP, Abrous DN, Le Moal M. Anatomical and behavioural comparison of unilateral dopamine-rich grafts implanted into the striatum of neonatal and adult rats. Neuroscience 1991;40:465-475.
37. Chritin M, Savasta M, Mennicken F, et al. Intrastriatal dopamine-rich implants reverse the increase of dopamine D2 receptor mRNA levels caused by lesion of the nigrostriatal pathway: a quantitative in situ hybridization study. Eur J Neurosci 1992;4:663-672.
38. Le Moine C, Normand E, Guitteny AF, Fouque B, Teoule R, Bloch B. Dopamine receptor gene expression by enkephalin neurons in rat forebrain. Proc Natl Acad Sci USA 1990; 87:230-234.
39. Lindefor N, Brene S, Herrera-Marschitz M, Persson H. Neuropeptide gene expression is differentially regulated by midbrain dopamine neurons. Exp Brain Res 1990;80:489-500.
40. Gerfen CR, McGinty JF, Young WS III. Dopamine differentially regulates dynorphin, substance P, and enkephalin expression in striatal neurons: in situ hybridization histochemical analysis. J Neurosci 1991;11:1015-1031.
41. Haverstick DM, Rubenstein A, Bannon MJ. Striatal tachykinin gene expression regulated by interaction of D1 and D2 dopamine receptors. J Pharmacol Exp Ther 1989;248:858-862.
42. Lindefors N, Tossman BU, Segovia J, Ungerstedt U. Tissue levels and in vivo release of tachykinin and GABA in striatum and substantia nigra of rat brain after unilateral striatal dopamine denervation. Exp Brain Res 1989;74:527-534.
43. Dunnett SB, Bjorklund A, Stenevi U, Iversen SD. Grafts of embryonic substantia nigra reinnervating the ventrolateral striatum ameliorate sensorimotor impairments and akinesia in rats with 6-OHDA lesions of the nigrostriatal pathway. Brain Res 1981;229:209-217.
44. Dunnett SB, Iversen SD. Sensorimotor impairments following localized kainic acid and 6-hydroxydopamine lesions of the neostriatum. Brain Res 1982;248:121-127.
45. Winocur G, Functional dissociation within the caudate nucleus of rats. J Comp Physiol Psychol 1974;86:432-439.