Hereditary and environmental risk factors; clinical and laboratory risk markers for head and neck, especially oral, cancer and precancer

European Journal of Cancer Prevention

Volumn 5, Issue 1, 1996, Pages 5-17

  Johnson, N W ^a,b   Warnakulasuriy, S ^a,b   Tavassoli, M ^a,b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b NONE

Author keywords

Aetiology; Epidemiology; Head and neck cancer; Oral cancer; Risk markers

Indexed keywords

ALCOHOL CONSUMPTION; APOPTOSIS; CANCER RISK; CELL PROLIFERATION; CHROMOSOME ABERRATION; ENVIRONMENT; GENETIC DISORDER; HEAD AND NECK CANCER; HUMAN; MORTALITY; MOUTH CANCER; PRIORITY JOURNAL; REVIEW; RISK FACTOR; SMOKING; SQUAMOUS CELL CARCINOMA; TUMOR SUPPRESSOR GENE;

ALCOHOL DRINKING; ARECA; ASIA; CARCINOMA, SQUAMOUS CELL; ENVIRONMENT; ENVIRONMENTAL POLLUTION; EUROPE; GENES, TUMOR SUPPRESSOR; HEAD AND NECK NEOPLASMS; HUMANS; INCIDENCE; MOUTH NEOPLASMS; ONCOGENES; PLANTS, MEDICINAL; PLANTS, TOXIC; PRECANCEROUS CONDITIONS; RISK FACTORS; SMOKING; TOBACCO, SMOKELESS; TUMOR MARKERS, BIOLOGICAL;

EID: 0030067866     PISSN: 09598278     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008469-199609000-00001     Document Type: Review

References (139)

1. Adamson R, Jones AS, Field JK (1994). Loss of heterozygosity studies on chromosome 17 in head and neck cancer using microsatillite markers. Oncogene 9: 2077-82.
2. Anderson JA, Irish JC, McLachlin CM, Ngan BY (1994). H-ras oncogcne mutation and human papillomavirus infection in oral carcinomas. Arch Otolaryngol Head Neck Surg 120: 755-60.
3. Avradopoulos D, Wanebo HJ, Mehta S, Blackinton D (1994). Mechanism of suppression of T-cell responses by head and neck cancer patient derived serum factors (Meeting abstract). Proc Annu Meeting Am Assoc Cancer Res 35: A2956.
4. Balslev I, Christensen IJ, Bruun Rasmussen B et al (1994). Flow cytometric DNA ploidy defines patients with poor prognosis in node-negative breast cancer. Int J Cancer 56: 16-25.
5. Bang G, Donath K, Thoresen S, Clausen OPF (1994). DNA flow cytometry of reclassified subtypes of malignant salivary gland tumors, J Oral Pathol Med 23: 291-7.
6. 1 regulation in human head and neck cancer. Cancer Res 55: 949-56.
7. Boffetta P, Merletti F, Magnani C, Terracini B (1994). A population-based study of prognostic factors in oral and oropharyngeal cancer. Eur J Cancer B Oral Oncol 30B: 369-73.
8. Brandwein M, Zeitlin J, Nuovo GJ et al (1994). HPV detection using 'hot start' polymerase chain reaction in patients with oral cancer: a clinicopathological study of 64 patients. Mod Pathol 7(7): 720-7.
9. Brugere J, Guenel P, Le Clerc A, Rodriguez J (1986). Differential effects of tobacco and alcohol in cancer of the larynx, pharynx and mouth. Cancer 57: 391-5.
10. Bryne M, Nielsen K, Koppang HS, Dabelsteen E (1991). Reproducibility of two malignancy grading systems with reportedly prognostic value for oral cancer patients. J Oral Pathol Med 20: 369-72.
11. Bundgaard T, Wildt J, Frydenberg M, Elbrond O, Nielsen JE (1995). Case-control study of squamous cell carcinoma of the oral cavity in Denmark. Cancer Causes Control 6: 57-67.
12. Chen YT, Xu L, Massey L et al (1994). Frameshift and nonsense p53 mutations in squamous cell carcinoma of head and neck: non-reactivity with three anti-p53 monoclonal antibodies. Int J Oncol 43: 609-14.
13. Chikamatsu K, Eura M, Matsuoka H et al (1994). The role of major histocompatibility complex expression on head and neck cancer cells in the induction of autologous cytotoxic T lymphocytes. Cancer Immunol Immunother 38: 358-64.
14. Copper MP, Jovanovic A, Nauta JJ et al (1995). Role of genetic factors in the etiology of squamous cell carinoma of the head and neck. Arch Otolaryngol Head Neck Surg 121: 157-60.
15. Cortesina G, De-Stefani A, Galeazzi E et al (1994). Temporary regression of recurrent squamous cell carcinoma of the head and neck is achieved with a low but not with a high dose of recombinant interleukin 2 injected perilymphatically. Br J Cancer 69: 572-6.
16. Corvo R, Sanguineti G, Scala M et al (1994). Primary site as predictive factor of local control in advanced head and neck tumors treated by concomitant boost accelerated radiotherapy. Tumori 80: 135-8.
17. Dabelsteen E, Clausen H, Mandel U (1991). Abberant glycosylation in oral malignant and premalignant lesions. J Oral Pathol Med 20: 361-8.
18. Day GL, Blot WJ, Shore RE et al (1994). Second cancers following oral and pharyngeal cancer: patients' characteristics and survival patterns. Eur J Cancer B Oral Oncol 30B: 381-6.
19. De Stefani E, Oreggia F, Ronco A, Fierro L, Rivero S (1994). Salted meat consumption as a risk factor for cancer of the oral cavity and pharynx: a case-control study from Uruguay. Cancer Epidemiol Biomarkers Prev 3: 381-5.
20. Dietz A, Senneweld E, Maier H (1995). Indoor air pollution by emissions of fossil fuel single stoves: possibly a hitherto underrated risk factor in the development of carcinomas of the head and neck. Otolaryngol Head Neck Surg 112: 308-15.
21. Enwonwu CO, Meeks VI (1995). Bionutrition and oral cancer in humans. J Crit Rev Oral Biol Med 6: 5-17.
22. Esser D, Meyer W, Willgeroth C, Motsch C (1994). Establishing factors relevant to prognosis in patients with carcinoma of the orophaynx or hypopharynx. HNO 42: 413-7.
23. Evans SJW, Langdon JD, Rapidis AD, Johnson NW (1982). Prognostic significance of STNMP and velocity of tumor growth in oral cancer. Cancer 49: 773-6.
24. Field JK, Tsiriyotis C, Zoumpourlis V et al (1994). Allele loss on chromosome 3 in squamous cell carcinoma of the head and neck correlates with poor clinical prognostic indicators. Int J Oncol 4/3: 543-9.
25. Fietkau R, Iro H, Tulusan AH et al (1994). Prognostic value of S-phase fraction in head and neck squamous cell carcinoma and nodal negative breast carcinomas. Strahlenther Onkol 179: 13-24.
26. Fischer M (1994). Prevalence of human papillomaviruses in non-malignant tissue of the ENT area. HNO 42: 325-6.
27. Formento JL, Francoual M, Ramaioli A et al (1994). Expression of epidermal growth factor receptor and survival in upper aerodigestive tract cancer. Bull Cancer 81/7: 610-15.
28. Franceschi S (1993). Oesophageal and oral cancer: aetiological factors. Eur J Cancer Prev 2: 2-3.
29. Franceschi S, Talamini R, Barra S et al (1990). Smoking and drinking in relation to cancers of the oral cavity, pharynx, larynx and esophagus in Northern Italy. Cancer Res 50: 6502-7.
30. Fukushima K, Ogura U, Watanabe S, Yabe Y, Masuda Y (1994). Human papillomavirus type 16 DNA detectd by the polymerase chain reaction in non-cancer tissues of the head and neck. Eur Arch Otorhinolaryngol 251: 109-12.
31. Gallo O, Boddi V, Bottai GV, Franchi A, Storchi OF (1995). Prognostic significance of clinically false positive cervical lymph nodes in patients with laryngeal carcinoma. Cancer 75: 1077-83.
32. Garewal HS, Schantz S (1995). Emerging role of beta-carotene and antioxidant nutrients in prevention of oral cancer. Arch Otolaryngol Head Neck Surg 121: 141-4.
33. Gluckman JL, Stambrook PJ, Pavelic ZP (1994). Prognostic significance of p53 protein accumulation in early stage T1 oral cavity cancer. Eur J Cancer B Oral Oncol 30B: 281.
34. Goldstein AM, Blot WJ, Greenberg RS et al (1994). Familial risk in oral and phryngeal cancer. Eur J Cancer B Oral Oncol 30B: 319-22.
35. Gorsky M, Silverman S, Jr (1994). Tobacco use in patients with head and neck carcinomas: habit changes and second primary oral/oropharyngeal cancers in patients from San Francisco. Cancer J 7: 78-80.
36. Gupta PC, Hamner JE, Murti PR (1992). Control of Tobacco-related Cancer and Other Diseases. Oxford University Press, India.
37. Hiratsuka H, Noguchi M, Kinjo H, Odajima T, Kohama G-I (1995). Two cases of tongue cancer treated with intra- and peri-tumoral injection of recombinant interleukin-2 alone: immunohistochemical considerations to clinical tumor response. Oral Dis 1: 166-71.
38. Honma S, Tsukada S, Honda S et al (1994). Biological-clinical significance of selective loss of HLA-Class I allelic product expression in squamous-cell carcinoma of the uterine cervix. Int J Cancer 57: 650-55.
39. Huber MH, Hong WK (1994). Biology and chemoprevention of head and neck cancer. Curr Probl Cancer 18: 81-140.
40. Idris AM, Prokopczyk B, Hoffmann D (1994). Toombak: a major risk factor for cancer of the oral cavity in Sudan. Prev Med 23: 832-9.
41. Iglesias J, Otero L, Amenedo M et al (1994). A clinical study of the Cyfra 211 in different tumors. Oncologia 17: 57-62.
42. Inki P, Joensuu H, Granman R et al (1994). Association between syndecan-1 expression and clinical outcome in squamous cell carcinoma of the head and neck. Br J Cancer 70: 319-23.
43. Jeng KC, Hsu CY, Liu MT, Chung TT, Liu ST (1994). Prevalence of Taiwan variant of Epstein Barr virus in throat washings from patients with head and neck tumors in Taiwan. J Clin Microbiol 32: 28-31.
44. Johnson NW (1977). Histological and histochemical studies of oral cancer. Int Dent J 27: 25-34.
45. Johnson NW (1991). Risk Markers for Oral Diseases, Vol 2: Oral Cancer: Detection of Patients and Lesions at Risk. Cambridge University Press, Cambridge.
46. Johnson NW, Ranasinghe AW, Warnakulasuriya KAAS (1993). Potentially malignant lesions and conditions of the mouth and oropharynx: natural history cellular and molecular markers of risk. Eur J Cancer Prev 2: 31-51.
47. Johnson NW, Ranasinghe AW, Warnakulasuriya KAAS (1994). HLA expression and p53 status in betel/tobacco quid related potentially malignant and malignant oral lesions in Sri Lanka. In Proceedings of the 3rd International Conference on Oral Cancer, Vol IIIA. Oral Oncology (ed Varma AK); Macmillan India, pp. 199-202.
48. Jones AS, Roland NJ, Field JK, Phillips DE (1994). The level of cervical lymph node metastases: their prognostic relevance and relationship with head and neck squamous carcinoma parimary sites. Clin Otolaryngol 19: 63-9.
49. Kabat GC, Chang CJ, Wynder EL (1994). The role of tobacco, alcohol use, and body mass index in oral and pharyngeal cancer. Int J Epidemiol 23: 1137-44.
50. Kaur J, Srivastava A, Ralhan R (1994). Overexpression of p53 protein in betel- and tobacco-related human oral dysplasia and squamous-cell carcinoma in India. Int J Cancer 58: 340-5.
51. Kiaris H, Jones AS, Spandidos DA, Vaughan ED, Field JK (1994a). Loss of heterozygoisty on chromosome 8 in squamous cell carcinomas of the head and neck. Int J Oncol 5: 1243-8.
52. Kiaris H, Spandidos DA, Jones AS, Field JK (1994b). Loss of heterozygosity and microsatellite instability of the H-ras gene in cancer of the head and neck. Int J Oncol 5: 579-82.
53. Kimura Y, Ata M, Nakamura S et al (1994). The evaluation of the newly produced assay kit for the cytokeratin fragment, 'Ball ELSA CYFRA21-1'. Kaka Igaku 31: 199-206.
54. King GN, Healy CM, Glover MT et al (1995). Increased prevalence of dysplastic and malignant lip lesions in renal-transplant recipients. N Engl J Med 332: 1052-7.
55. Kuo MY, Jeng JH, Chiang CP, Hahn LJ (1994). Mutations of Ki-ras oncogene codon 12 in betel quid chewing-related human oral squamous cell carcinoma in Taiwan. J Oral Pathol Med 23: 70-4.
56. Kuttan NAA, Rosin MP, Ambiak K et al (1995). High prevalence of expression of p53 oncoprotein in oral carcinomas from India associated with betel and tobacco chewing. Eur J Cancer B Oral Oncol 31B: 169-74.
57. Lal H (1994). Biochemical studies in head and neck cancer. Clin Biochem 27: 235-43.
58. Lamey PJ, Douglas PS, Napier SS (1994). Secretor status and oral cancer. Br J Oral Maxillofac Surg 32: 214-7.
59. Larsen ET, Buggan MA, Inoue M (1994). Absence of human papilloma virus DNA in oropharyngeal spindle-cell squamous caricnomas. Am Clin Pathol 101: 514-8.
60. Lee NK, Ye YW, Schweitzer C, Nisen PD (1994). Allelic loss of chromosome 13 can preceed histological changes in head and neck cancer. Int J Oncol 5: 205-10.
61. Leemans CR, Tiwara R, Nauta JJ, van der Waal I, Snow GB (1994). Recurrence at the primary site in head and neck cancer and the significance of neck lymph node metastases as a prognostic factor. Cancer 73: 187-90.
62. Li X, Lee NK, Ye YW et al (1994). Allelic loss at chromosomes 3p, 8p, 13q and 17p associated with poor prognosis in head and neck cancer. J Natl Cancer Inst 86: 1524-9.
63. Lippman SM, Benner SE, Hong WK (1994). Cancer chemoprevention. J Clin Oncol 12: 851-73.
64. MacFarlane GJ, Boyle P, Evstifeeva TV, Robertson C, Scully C (1994). Rising trends of oral cancer mortality among males worldwide: the return of an old public health problem. Cancer Causes Control 5: 259-65.
65. MacFarlane GJ, Sharp L, Porter S, Franceschi S (1996). Trends in survival from cancers of the oral cavity and pharynx in Scotland: a clue as to why the disease is becoming more common? Br J Cancer, in press.
66. MacFarlane GJ, Zheng T, Marshall JR (1995). Alcohol, tobacco, diet and the risk of oral cancer: a pooled analysis of three case-control studies. Eur J Cancer B Oral Oncol 31B: 181-8.
67. Maher R, Lee AJ, Warnakulasuriya KAAS, Lewis JA, Johnson NW (1994). Role of areca nut in the causation of oral submucous fibrosis: a case- control study in Pakistan. J Oral Pathol Med 23: 65-9.
68. Maier H, Fischer G, Sennewald E, Heller WD (1994). Occupational risk factors for pharyngeal cancer. Results of the Heidelberg Pharyngeal Cancer Study. HNO 42: 530-40.
69. Makino K, Ogata T, Miyake H, Habu S, Nishimura T (1994). Expression of tumor-associated glycoantigen, sialyl Lewis(a), a human head and neck squamous cell carcinoma and its application to tumor immunotherapy. Jpn J Cancer Res 85: 887-91.
70. Mamelle G, Pampurik J, Luboinski et al (1994). Lymph node prognostic factors in head and neck squamous cell carcinoma. Am J Surg 168: 494-8.
71. Man T (1994). Solid tumours - chemoprevention with retinoids. Synopsis of workshop discussions. Leukemia 8: S87-92.
72. Mao EJ, Smith CJ (1993). Detection of Epstein-Barr virus (EBV) DNA by the polymerase chain reaction (PCR) in oral smears from heatlhy individuals and patients with squamous cell carcinoma. J Oral Pathol Med 22: 12-7.
73. Marley JJ, Robinson PA, Hume WJ (1994). Expression of human cytokeratin 14 in normal, premalignant and malignant oral tissue following isolation by plaque differential hybridisation. Eur J Cancer B Oral Oncol 30B: 305-11.
74. McGuirt WF, Davis SP (1995). 3rd Demographic portrayal and outcome analysis of head and neck cancer surgery in the elderly. Arch Otolaryngol Head Neck Surg 121: 150-4.
75. Metzger K, Angres G, Maier H, Lehmann WD (1995). Lipoxygenase products in human saliva: patients with oral cancer compared to controls. Free Radical Biol Med 18/2: 185-94.
76. Milasin J, Pujic N, Dedovic N et al (1994). High incidence of H-ras oncogene mutations in squmous cell carcinoma of lip vermilion. J Oral Pathol Med 23: 298-301.
77. Min BM, Baek JH, Shin KH et al (1994). Inactivation of the p53 gene by either mutation or HPV infection is extremely frequent in human oral squamous cell carcinoma cell lines. Eur J Cancer B Oral Oncol 30: 338-45.
78. Miyagi M, Soda T, Nakashima T (1994). Flow cytometric DNA analysis and chemosensitivity in squamous cell carcinoma of the head and neck. Nippon Jibiinkoka Gakkai Kaiho 97: 2247-58.
79. Molina R, Torres MD, Moragas M et al (1994). Study of the squamous cell carcinoma tumor antigen as a prognostic indicator in patients with head and neck neoplasms. Neoplasia 11: 126-31.
80. Moller H (1989). Changing indicence of cancer of the tongue, oral cavity and pharynx in Denmark. J Oral Pathol Med 18: 224-9.
81. Morgan PR, Su L (1994). Intermediate filaments in oral neoplasia. I. Oral cancer and epithelial dyspalsia. Eur J Cancer B Oral Oncol 30B: 160-6.
82. Muller D, Millon R, Lidereau R (1994). Frequent amplification of 11q13 DNA markers is associated with lymph node involvement in human head and neck squamous cell carcinomas. Eur J Cancer B Oral Oncol 30B: 113-20.
83. Narayanan S (1994). Sialic acid as a tumor marker. Ann Clin Lab Sci 24: 376-84.
84. Nawroz H, van der Riet P, Hruban RH et al (1994). Allelotype of head and neck squamous cell carcinoma. Cancer Res 54: 1152-5.
85. Niedobitek G, Young LS (1994). Epstein-Barr virus persistence and virus-associated tumors. Lancet 343: 333-5.
86. Nylander K, Anneroth G, Gustafsson H et al (1994). Cell kinetics of head and neck squamous cell carcinomas-prognostic implications. Acta Oncol 33: 23-8.
87. Ogden GR, Cowpe JG, Chisholm DM, Lane EB (1994). DNA and keratin analsyis of oral exfoliative cytology in the detection of oral cancer. Eur J Cancer B Oral Oncol 30B: 405-8.
88. Owens W, Field JK, Howard PJ, Stell PM (1992). Multiple cytogenetic aberrations in squamous cell carcinomas of the head and neck. Eur J Cancer B Oral Oncol 28B: 17-23.
89. Parise O, Janot F, Guerry R (1994). Chromosome 11q13 gene amplifications in head and neck squamous cell carcinomas: relation with lymph node invasion. Int J Oncol 5: 309-13.
90. Parkin DM, Pisani P, Ferlay J (1993). Estimates of the worldwide incidence of eighteen major cancers in 1985. Int J Cancer 54: 594-606.
91. Partridge M, Kiguwa S, Langdon JD (1994). Frequent deletion of chromosome 3p in oral squamous cell carcinoma. Eur J Cancer B Oral Oncol 30B: 248-51.
92. Patel AM, Incognito LS, Wasilenko WJ, Schechter GL, Somers KD (1994a). Amplification and expression of ems-1 in head and neck tumor cell lines (meeting abstract). Proc Annu Meeting Am Assoc Cancer Res 35: A3286.
93. Patel RK, Trivedi AH, Jaju RJ, Adhvaryu SG, Balar DB (1994b). Ethanol potentiates the clastogenicity of pan masala - an in vitro experience. Carcinogenesis 15: 2017-21.
94. Pisani P, Parkin DM, Ferlay J (1993). Estimates of the worldwide mortality from eighteen major cancers in 1985. Implications for prevention and projections of future burden. Int J Cancer 55: 891-903.
95. Rajendran R, Warnakulasuriya KAAS, Rogers GR, Johnson NW (1990). Altered H antigen reactivity of keratinocytes as a possible prognostic indicator in oral submucous fibrosis. Br Soc Oral Pathol (abstract) pp. 7.
96. Ranasinghe AW, Warnakulasuriya KAAS, Johnson NW (1993). Low prevalence of expression of p53 (oncoprotein in oral carcinomas from Sri Lanka associated with betel and tobacco chewing. Eur J Cancer B Oral Oncol 29B: 147-50.
97. Rao PH, Sreekantaiah C, Schantz SP, Chaganti RS (1994). Cytogenic analysis of 11 squamous cell carcinoams of the head and neck. Cancer Genet Cytogenet 77: 60-4.
98. Rassekh CH, Johnson JT, Eibling DE (1994). Circulating markers in squamous cell carcinoma of the head and neck: a review. Eur J Cancer B Oral Oncol 30: 23-8.
99. Regezi JA, Zarbo RJ, Regev E et al (1995). p53 protein expression in sequential biopsies or oral dysplasias and in situ carcinomas. J Oral Pathol Med 24: 18-22.
100. Rogers MA, Vaughan TL, Davis S, Thomas DB (1995). Consumption of nitrate, nitrite and nitrosodimethylamine and the risk of upper aerodigestive tract cancer. Cancer Epidemiol Biomarkers Prev 4: 29-36.
101. Roland NJ, Caslin AW, Bowie GL, Jones AS (1994). Has the cellular proliferation marker Ki67 any clinical relevcance in squamous cell carcinoma of the head and neck? Clin Otolaryngol 19: 13-8.
102. Rubin JS, Qiu L, Etkind P (1995). Amplification of the Int-2 gene in head and neck squamous cell carcinoma. J Laryngol Otol 109: 72-6.
103. Schwartz LH, Ozsahin M, Zhang GN et al (1994). Synchronous and metachronous head and neck carcinomas. Cancer 74: 1933-8.
104. Shah JP, Anderson PE (1994). The impact of patterns of nodal metastasis on modifications of neck dissection. Ann Surg Oncol 1: 521-32.
105. Shin DM, Ro JY, Hong WK, Hittleman WN (1994). Dysregulation of epidermal growth factor receptor expression in premalignant lesions during head and neck tumorigenesis. Cancer Res 54: 3153-9.
106. Slootweg PJ, de Pagter M, de Weger RA, de Wilde PC (1994). Lymphocytes at tumor margins in patients with head and neck cancer. Relationship with tumor size, human lymphocyte antigen molecules, and metastasis. Int J Oral Maxillofac Surg 23: 286-9.
107. Somers KD, Incognito LS, Blevins JD, Schechter GL (1994). Amplification at chromosome 11q13 in head and neck cancer: association with lymph node metastasis (meeting abstract). Proc Annu Meeting Am Assoc Cancer Res 35: A3251.
108. Sorscher SM, Russack V, Cagle M et al (1995). Immunolocalization of E-cadherin in human head and neck cancer. Arch Pathol Lab Med 119: 81-4.
109. Soylu L, Ozcan C, Cetik F et al (1994). Serum levels of tumor necrosis factor in squamous cell carcinoma of the head and neck. Am J Otolaryngol 15(4): 281-5.
110. Speight P (1995). Cell adhesion molecules in oral cancer. Proceedings of the 4th International Conference on Oral Cancer, Vol IVB. Oral Oncology (ed Varma AK, Mori M); Macmillan, India, pp. 299-302.
111. Sugerman PB (1995). The role of oncogenes, tumour suppressor genes and growth factors in oral squamous cell caricnoma: a case of apoptotis versus proliferation. Oral Dis 1: 172-88.
112. Susal C, Maier H, Lorenz K, Opelz G (1994). Association of IgA-anti-Fab autoantibodies with disease stage in head and neck cancer. Int J Cancer 57: 47-50.
113. Suzuki K, Chen RB, Nomura T, Nakajima T, Ruskin JD (1994). Flow cytometric analysis of primary and metastatic squamous cell carcinoma of the oral and maxillofacial region. J Oral Maxillofac Surg 52: 855-61.
114. Suzuki M (1995). Immunohistochemical distribution of laminin in squamous cell carcinoma of the head and neck - correlations between laminin staining and clinical and histological features. Nippon Jibiinkoka Gakkai Kaiho 98: 216-25.
115. Talacko AA, Shirlaw PJ, Johnson NW (1991a). Growth factors and their receptors as markers of the high risk lesion, with special reference to epidermal growth factors. In Risk Markers for Oral Diseases Vol 2: Oral Cancer: Detection of Patients and Lesions at Risk, University Press, Cambridge, pp. 294-316.
116. Talacko AA, Teo CG, Griffin BE, Johnson NW (1991b). Epstein-Barr virus receptors but not viral DNA are present in normal and malignant oral epithelium. J Oral Pathol Med 20: 20-5.
117. Tanaka T (1995). Chemoprevention of oral carcinogenesis. Eur J Cancer Oral Oncol 31B: 3-15.
118. Taylor-Papadimitriou J, Epenetos AA (1994). Exploiting altered glycosylation patterns in cancer: progress and challenges in diagnosis and therapy. Trends Biotechnol 12: 227-33.
119. Thomas S, Wilson A (1993). A quantitative evaluation of the aetiological role of betel quid in oral carcinogeneis. Eur J Cancer B Oral Oncol 29B: 265-72.
120. Thompson AC, Bradley PJ, Griffin NR (1994). Tumor-associated tissue cosinophilia and long-term prognosis for carcinoma of the larynx. Am J Surg 168: 469-71.
121. Toma S, Palumbo R, Raffo P, Spadini N, Rosso R (1994). 13-cis-retinoic acid, beta-carotene and other anti-oxidant agents in chemoprevention and therapy of head and neck cancer. Eur J Cancer Prev 3: 374-7.
122. Tsuge H, Hasegawa Y, Matsuura H et al (1994). Determining the most effective therapeutic methods as a primary treatment for squamous cell carcinoma of the oropharynx. Nippon Jibiinkoka Gakkai Kaiho 97: 1631-42.
123. van der Riet P, Nawroz H, Hruban RH et al (1994). Frequent loss of chromosome 9p21-22 early in head and neck cancer progression. Cancer Res 54: 1156-8.
124. Van Wyk CW, Stander I, Padayachee A, Grobler-Rabie AF (1993). The areca nut chewing habit and oral squamous cell carcinoma in South African Indians: a retrospective study. S Afr Med J 83: 425-9.
125. Van Dyke DL, Worsham MJ, Benninger MS et al (1994). Recurrent cytogenetic abnormalities in squamous cell carcinoma of the head and neck region. Genes Chromosom Cancer 9: 192-206.
126. Warnakulasuriya S (1995). The role of betel-quid in oral carcinogenesis. In Betel-quid and Tobacco Chewing Among the Bangladeshi Community in the United Kingdom: Usage and Health Issues. Centre for Transcultural Oral Health, London, UK, pp. 61-70.
127. Warnakulasuriya KAAS, Johnson NW (1992). Expression of p53 mutant nuclear phosphoprotein in oral carcinoma and potentially malignant oral lesions. J Oral Pathol Med 21: 404-8.
128. Warnakulasuriya KAAS, McDonald DG (1994). Epithelial cell kinetics in oral leukoplakia. J Oral Pathol Med 24: 165-9.
129. Warnakulasuriya KAAS, Chang SE, Johnson NW (1992). Point mutations in the Ha-ras oncogene are detectable in formalin-fixed tissues of oral squamous cell carcinomas, but are infrequent in British cases. J Oral Pathol Med 21: 225-9.
130. Warnakulasuriya KAAS, Johnson NW (1993). Nucleolar organiser region (NOR) distribution as a diagnostic markers in oral keratosis, dysplasia and squamous cell carcinoma. J Oral Pathol Med 22: 77-81.
131. Weymuller EA, Ahmad K, Casiano RR (1994). Surgical reporting instrument designed to improve outcome data in head and neck cancer trials. Ann Otol Rhinol Laryngol 103: 499-509.
132. Winn DM (1995). Diet and nutrition in the etiology of oral cancer. Am J Clin Nutr 61: 437S-45S.
133. Woolgar JA, Vaughan ED, Scott J, Brown JS (1994). Pathological findings in clinically false-negative and false-positive neck dissections for oral carcinoma. Ann R Coll Surg Engl 76: 237-44.
134. Woolgar JA, Brown JS, Scott J et al (1995). Survival, metastasis and recurrence of oral cancer in relation to pathological features. Ann R Coll Surg Eng 77: 325-31.
135. Xing RD, Wang ZS, Li CQ et al (1994). Total sialic acid as a tumor marker for oral cancer. Int J Biol Markers 9: 239-42.
136. Xu XC, Ro JY, Lee JS et al (1994). Differential expression of nuclear retinoid receptors in normal, premalignant and malignant head and neck tissues. Cancer Res 54: 3580-7.
137. Yoo GH, Xu HJ, Brennan JA et al (1994). Infrequent inactivation of the retinoblastoma gene despite frequent loss of chromosome 13q in head and neck squamous cell carcinoma. Cancer Res 54: 4603-6.
138. Zheng T, Boyle P, Hu H et al (1990). Dentition, oral hygiene and risk of oral cancer: a case-control study in Beijing, People's Republic of China. Cancer Causes Control 1: 235-41.
139. Zoeller J, Flentje M, Sinn P, Born IA (1994). Evaluation of AgNOR and Ki-67 antigen as cell kinetic parameters in oral dysplasias and carcinomas. Anal Cell Pathol 7: 77-88.