Corticosteroids inhibit expression of inducible nitric oxide synthase during acute cardiac allograft rejection

Transplantation

Volumn 61, Issue 2, 1996, Pages 324-328

  Worrall, Neil K ^a   Misko, Thomas P ^b   Sullivan, Patrick M ^b   Hui, Jia J ^a   Rodi, Charles P ^b   Ferguson Jr , T Bruce ^a,c  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MONSANTO COMPANY   (United States)

^c Division of Cardiothoracic Surgery   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTEROID; NITRIC OXIDE SYNTHASE;

ALLOGRAFT; ARTICLE; CELL INFILTRATION; ENZYME ACTIVITY; ENZYME INDUCTION; GENE EXPRESSION; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; HISTOPATHOLOGY; MONONUCLEAR CELL; NONHUMAN; PRIORITY JOURNAL; RAT;

ADRENAL CORTEX HORMONES; ANIMALS; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GRAFT REJECTION; HEART TRANSPLANTATION; NITRIC OXIDE SYNTHASE; RATS; RATS, INBRED ACI; RATS, INBRED LEW; TRANSPLANTATION, HOMOLOGOUS;

EID: 0030067585     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199601270-00028     Document Type: Article

References (22)

1. Worrall NK, Lazenby WD, Misko TP, et al. Modulation of in vivo alloreactivity by inhibition of inducible nitric oxide synthase. J Exp Med 1995; 181: 63.
2. Lancaster JR, Langrehr JM, Bergonia HA, Murase N, Simmons RL, Hoffman RA. EPR detection of heme and nonheme iron-containing protein nitrosylation by nitric oxide during rejection of rat heart allograft. J Biol Chem 1992; 267: 10, 994.
3. Yang X, Chowdhury N, Cai B, et al. Induction of myocardial nitric oxide synthase by cardiac allograft rejection. J Clin Invest 1994; 94: 714.
4. Devlin J, Palmer RMJ, Gonde CE, et al. Nitric oxide generation: a predictive parameter of acute allograft rejection. Transplantation 1994; 58: 592.
5. Moncada S, Palmer RMJ, Higgs EA. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 1991; 43: 109.
6. Nathan C. Nitric oxide as a secretory product of mammalian cells. FASEB J 1992; 6: 3051.
7. Corbett JA, Tilton RG, Chang K, et al. Aminoguanidine, a novel inhibitor of nitric oxide formation, prevents diabetic vascular dysfunction. Diabetes 1992; 41: 552.
8. Misko TP, Moore WM, Kasten TP, et al. Selective inhibition of the inducible nitric oxide synthase by aminoguanidine. Eur J Pharmacol 1993; 233: 119.
9. Radomski MW, Palmer RMJ, Moncada S. Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells. Proc Natl Acad Sci USA 1990; 87: 10, 043.
10. Di Rosa M, Radomski M, Carnuccio R, Moncada S. Glucocorticoids inhibit the induction of nitric oxide synthase in macrophages. Biochem Biophys Res Commun 1990; 172: 1246.
11. Geller DA, Nussler AK, Di Silvio M, et al. Cytokines, endotoxin, and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes. Proc Natl Acad Sci USA 1993; 90: 522.
12. Boughton-Smith NK, Evans SM, Laszlo F, Whittle BJR, Moncada S. The induction of nitric oxide synthase and intestinal vascular permeability by endotoxin in the rat. Br J Pharmacol 1993; 110: 1189.
13. Liu S, Adcock IM, Old RW, Barnes PJ, Evans TW. Lipopolysaccharide treatment in vivo induces widespread tissue expression of inducible nitric oxide synthase mRNA. Biochem Biophys Res Commun 1993; 196: 1208.
14. Ono K, Lindsey ES. Improved technique of heart transplantation in rats. J Thorac Cardiovasc Surg 1969; 57: 225.
15. Misko TP, Schilling RJ, Salvemini D, Moore WM, Currie MG. A fluorometric assay for the measurement of nitrite in biological samples. Anal Biochem 1993; 214: 11.
16. Bredt DS, Snyder SH. Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. Proc Natl Acad Sci USA 1990; 87: 682.
17. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72: 248.
18. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987; 162: 156.
19. Billingham ME. Diagnosis of cardiac rejection by endomyocardial biopsy. Heart Transplant 1981; 1: 25.
20. Provoost AP, De Keijzer MH, Kort WJ, Wolff ED. Superiority of continuous infusion of prednisolone over daily injections in the prolongation of heart allograft survival in rats. Transplantation 1982; 34: 221.
21. Dallman MJ, Larsen CP, Morris PJ. Cytokine gene transcription in vascularised organ grafts: analysis using semiquantitative polymerase chain reaction. J Exp Med 1991; 174: 493.
22. Snyder DS, Unanue ER. Corticosteroids inhibit immune macrophages'la expression and interleukin-1 production. J Immunol 1982; 129: 1803.