Cultured human Langerhans' cells are superior to fresh cells at presenting native HIV-1 protein antigens to specific CD4+ T-cell lines

Immunology

Volumn 87, Issue 2, 1996, Pages 310-316

  Girolomoni, G ^a   Valle, M T ^b   Zacchi, V ^c   Costa, M G ^b   Giannetti, A ^a,b   Manca, F ^b  

^a LABORATORIO DI PATOLOGIA VASCOLARE   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

^c UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CHLOROQUINE; LEUPEPTIN; MONOCLONAL ANTIBODY;

ARTICLE; CELL CULTURE; CELL PROLIFERATION; HISTOCOMPATIBILITY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNITY; IMMUNOGENICITY; LANGERHANS CELL; MONOCYTE; MONONUCLEAR CELL; PRIORITY JOURNAL; T LYMPHOCYTE;

ANTIGEN PRESENTATION; CD4-POSITIVE T-LYMPHOCYTES; CELL LINE; CELLS, CULTURED; CHLOROQUINE; HIV ANTIGENS; HIV-1; HUMANS; LANGERHANS CELLS; LEUPEPTINS; LYMPHOCYTE ACTIVATION; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 0030067471     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (54)

1. STEINMAN R.M. (1991) The dendritic cell system and its role in immunogenicity. Annu Rev Immunol 9, 271.
2. + T cells in vitro: characteristics and antigen-presenting cell requirements. J Exp Med 176, 1431.
3. + T lymphocytes to peptide antigen in vivo. J Immunol 151, 6742.
4. PAGLIA P., GIROLOMONI G., ROBBIATI F., GRANUCCT F. & RICCIARDI-CASTAGNOLI P. (1993) Immortalized dendritic cell line fully competent in antigen presentation initiates primary T cell responses in vivo. J Exp Med 178, 1893.
5. + T-cell lines specific for gp120. J Acquir Immune Defic Syndr 7, 15.
6. ROMANI N. & SCHULER G. (1992) The immunologie properties of epidermal Langerhans' cells as a part of the dendritic cell system. Springer Semin Immunopathol 13, 265.
7. MOLL H. (1993) Epidermal Langerhans' cells are critical for immunoregulation of cutaneous leishmaniasis. Immunol Today 14, 383.
8. GIANNETTI A., ZAMBRUNO G., CIMARELLI A. et al. (1993) Direct detection of HIV-1 RNA in epidermal Langerhans' cells of HIV-infected patients. J Acquir Immune Defic Syndr 6, 329.
9. CIMARELLI A., ZAMBRUNO G., MARCONI A., GIROLOMONI G., BERTAZZONI U. & GIANNETTI A. (1994) Quantitation by competitive PCR of HIV-1 proviral DNA in epidermal Langerhans' cells of HIV-infected patients. J Acquir Immune Defic Syndr 7, 230.
10. RAPPERSBERGER K., GARTNER S., SCHENK P. et al. (1988) Langerhans' cells are an actual site of HIV-1 replication. Intervirology 29, 185.
11. TEUNISSEN M.B.M., RONGEN H.A.H. & Bos J.D. (1994) Function of adhesion molecules LFA-3 and ICAM-1 on human epidermal Langerhans' cells in antigen-specific T-cell activation. J Immunol 152, 3400.
12. ZAMBRUNO G., COSSARIZZA A., OTTANI D. et al. (1995) Functional ICAM-3 is expressed by freshly isolated epidermal Langerhans' cells and is not regulated during culture. J Invest Dermatol 105, 215.
13. GIROLOMONI G., ZAMBRUNO G., MANFREDINI R. et al. (1993) Expression of B7 costimulatory molecule in cultured human epidermal Langerhans' cells is regulated at the mRNA level. J Invest Dermatol 103, 54.
14. DAI R., GRAMMER S.F. & STREILEIN J.W. (1993) Fresh and cultured Langerhans' cells display differential capacities to activate hapten-specific T cells. J Immunol 150, 59.
15. AIBA S. & KATZ S.I. (1989) The ability of cultured Langerhans' cells to process and present protein antigens is MHC-dependent. J Immunol 146, 2479.
16. DE BRUIJN M.L.H., NIELAND J.D., HARDING C.V. & MELIEF C.J.M. (1992) Processing and presentation of intact hen egg-white lysozyme by dendritic cells. Eur J Immunol 22, 347.
17. ROMANI N., KOIDE S., CROWLEY M. et al. (1989) Presentation of exogenous protein antigens by dendritic cells to T cell clones. J Exp Med 169, 1169.
18. KOCH F., TROCKENBACHER B., KÄMPGEN E. et al. (1995) Antigen processing in populations of mature murine dendritic cells is caused by subsets of incompletely matured cells. J Immunol 155, 93.
19. COHEN P.J. & KATZ S.I. (1992) Cultured human Langerhans' cells process and present intact protein antigens. J Invest Dermatol 99, 331.
20. MANCA F., WALKER L., NEWELL A., CELADA F., HABESHAW J.A. & DALGLEISH A.G. (1992) Inhibitory activity of HIV envelope gp120 dominates over its antigenicity for human T cells. Clin Exp Immunol 88, 17.
21. MANCA F., HABESHAW J., DALGLEISH A.G., FENOGLIO D., LI PIRA G. & SERCARZ E.E. (1993) Role of flanking variable sequences in antigenicity of consensus regions of HIV gp120 for recognition by specific human T helper clones. Eur J Immunol 23, 269.
22. MYERS G., RABSON A.B., BERZOFSKY J.A., SMITH T.F. & WONGSTAAL F. (1990) Human Retrovirus and AIDS. A Compilation and Analysis of Nucleic Acid and Amino Acid Sequences. Los Alamos National Laboratory, Los Alamos.
23. MANCA F., HABESHAW J. & DALGLEISH A.G. (1991) The naive repertoire of human T helper cells specific for gp120. the envelope glycoprotein of HIV. J Immunol 146, 1964.
24. BIRD A.G., MCLACHLAN S.M. & BRITTON S. (1981) Cyclosporin A promotes spontaneous outgrowht in vitro of Epstein-Barr virus-induced B cell lines. Nature 289, 300.
25. + T cells can discriminate the molecular context of immunodominant epitopesof HIV gp120 and HIV p66. J Acquir Immune Defic Syndr 9, 227.
26. SONTHEIMER R.D. (1983) The mixed epidermal cell-lymphocyte reaction. J Immunol 130, 2612.
27. RES P., KAPSENBERG M.L., Bos J.D. & STIEKEMA F. (1987) The crucial role of human dendritic antigen-presenting cell subsets in nickel-specific T-cell proliferation. J Invest Dermatol 88, 550.
28. GIROLOMONI G., CRUZ P.D. & BERGSTRESSER P.R. (1990) Internalization and acidification of surface HLA-DR molecules by epidermal Langerhans' cells: a paradigm for antigen processing. J Invest Dermatol 94, 753.
29. VIDARD L., ROCK K.L. & BENACERRAF B. (1992) Eterogeneity in antigen processing by different cell types of antigen-presenting cells. Effect of cell culture on antigen processing ability. J Immunol 149, 1905.
30. BENAROCH P., YILLA M., RAPOSO G. et al. (1995) How MHC class II molecules reach the endocytic route. EMBO J 14, 37.
31. SIMON J.C., CRUZ P.D., TIGELAAR R.E., SONTHEIMER R.D. & BEROSTRESSER P.R. (1991) Adhesion molecules CD11a, CD18, and ICAM-1 on human epidermal Langerhans' cells serve a functional role in the activation of alloreactive T cells. J Invest Dermatol 96, 148.
32. THOMAS R., DAVIES L.S. & LIPSKY P.E. (1993) Isolation and characterization of human peripheral blood dendritic cells. J Immunol 150, 821.
33. O'DOHERTY U., STEINMAN R.M., PENG M. et al. (1993) Dendritic cells freshly isolated from human blood express CD4 and mature into typical immunostimulatory dendritic cells after culture in monocyte-conditioned medium. J Exp Med 178, 1067.
34. HOLT PG, OLIVIER J, BILYK N. et al. (1993) Downregulation of the antigen presenting function(s) of pulmonary dendritic cells in vivo by resident alveolar macropahges. J Exp Med 177, 397.
35. GIROLOMONI G., SIMON J.C., BERGSTRESSER P.R. & CRUZ P.D. (1990) Freshly isolated spleen dendritic cells and freshly isolated epidermal Langerhans' cells undergo similar phenotypic and functional changes during short term culture. J Immunol 145, 2820.
36. GIROLOMONI G., ZAMBRUNO G., MANCA V., BERGSTRESSER P.R., GIANNETTI A. & CRUZ P.D. (1992) Spleen dendritic cells exhibit altered morphology and increased allostimulatory capacity after short term culture. Exp Dermatol 1, 129.
37. KOCK F., HEUFLER C., KAMPGEN E., SCHNEEWEISS D., BÖCK G. & SCHÜLER G. (1990) Tumor necrosis factor α maintains the viability of murine epidermal Langerhans' cells in culture, but in contrast to granulocyte/macrophage colony-stimulating factor, without inducing their functional maturation. J Exp Med 171, 159.
38. MARKOWICZ S. & ENGLEMAN E. (1990) Granulocyte-macrophage colony stimulating factor promotes differentiation and survival of human peripheral blood dendritic cells in vitro. J Clin Invest 85, 955.
39. ENK A.H., ANGELONI V.L., UDEY M.C. & Katz S.I. (1993) An essential role for Langerhans' cell-derived IL-1β in the initiation of primary immune responses in skin. J Immunol 150, 3698.
40. PURÉ E., INABA K., CROWLEY M.T. et al. (1990) Antigen processing by epidermal Langerhans' cells correlates with the level of biosynthesis of major histocompatibility complex class II molecules and expression of invariant chains. J Exp Med 172, 1459.
41. STÖSSEL H., KOCH F., KÄMPGEN E. et al. (1990) Disappearance of certain acidic organelles (endosomes and Langerhans' cell granules) accompanies loss of antigen processing capacity upon culture of epidermal Langerhans' cells. J Exp Med 172, 1471.
42. GIROLOMONI G., STONE D.K., BERGSTRESSER P.R. & CRUZ P.D. (1991) Vacuolar acidification and bafilomycin-sensitive proton translocating ATPase in human epidermal Langerhans' cells. J Invest Dermatol 96, 735.
43. KÄMPGEN E., KOCH N., KOCH F. et al. (1991) Class II major histocompatibility complex molecules of murine dendritic cells: synthesis, sialylation of invariant chain, and antigen processing capacity are down-regulated upon culture. Proc Natl Acad Sci USA 88, 3014.
44. BECKER D., RESKE-KUNZ A.B., KNOP J. & RENSKE K. (1991) Biochemical properties of MHC class II molecules endogenously synthesized and expressed by mouse Langerhans' cells. Eur J lmmunol 21, 1213.
45. KLEIJMEER M.J., OORSCHOT V.M.J. & GEUZE H.J. (1994) Human resident Langerhans' cells display a lysosomal compartment enriched in MHC class II. J Invest Dermatol 103, 516.
46. MOMMAAS A.M., MLIDLER A.A., OUT C.J. et al. (1995) Distribution of HLA-class II molecules in epidermal Langerhans' cells in situ. Eur J Immunol 25, 520.
47. DAVIDSON H.W., REID P.A., LANZAVECCHIA A. & WATTS C. (1991) Processed antigen binds to newly synthesized MHC class II molecules in antigen-specific B lymphocytes. Irreversible association of peptides with class II MHC molecules in living cells. Cell 67, 105.
48. ROCHE P.A., TELETSKI C.L., STANG E., BAKKE O. & LONG E.O. (1993) Cell surface HLA-DR-invariant chain complexes are targeted to endosomes by rapid internalization. Proc Natl Acad Sci USA 90, 8581.
49. PINET V., VERGELLI M., MARTIN R., BAKKE O. & LONG E.O. (1995) Antigen presentation mediated by recycling of surface HLA-DR molecules. Nature 375, 603.
50. CAUX C., DEZUTTER-DAMBUYANT C., SCHMITT D. & BANCHEREAU J. (1992) GM-CSF and TNFα cooperate in the generation of dendritic Langerhans' cells. Nature 360, 258.
51. + progenitors in human bone marrow. J Immunol 149, 2681.
52. SALLUSTO F. & LANZAVECCHIA A. (1994) Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor α. J Exp Med 179, 1109.
53. ROMANI N., GRUNER S., BRANG D. et al. (1994) Proliferating dendritic cell progenitors in human blood. J Exp Med 180, 83.
54. BLAUVELT A., CLERICI M., LUCEY D.R. et al. (1995) Functional studies of epidermal Langerhans' cells and blood monocytes in HIV-infected persons. J Immunol 154, 3506.