Purification and identification of a novel and four known serine proteinase inhibitors secreted by human glioblastoma cells

Journal of Biochemistry

Volumn 119, Issue 2, 1996, Pages 334-339

  Koshikawa, Naohiko ^a   Nakamura, Takashi ^a   Tsuchiya, Naoto ^a   Isaji, Mitsuko ^b   Yasumitsu, Hidetaro ^a   Umeda, Makoto ^a   Miyazaki, Kaoru ^a  

^a YOKOHAMA CITY UNIVERSITY   (Japan)

^b MOCHIDA PHARMACEUTICAL CO   (Japan)

Author keywords

Cancer; Glioblastoma; Reverse zymography; Serine proteinase inhibitor; Trypsin inhibitor

Indexed keywords

AMYLOID PRECURSOR PROTEIN; BINDING PROTEIN; KALLIKREIN; PLACENTA PROTEIN 5; PLASMINOGEN; SECRETORY LEUKOCYTE PROTEINASE INHIBITOR; SERINE PROTEINASE INHIBITOR; TRYPSIN; TRYPSIN INHIBITOR; TRYPSINOGEN;

AFFINITY CHROMATOGRAPHY; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CELL SECRETION; CONTROLLED STUDY; GLIOBLASTOMA; HUMAN; HUMAN CELL; PROTEIN PURIFICATION;

EID: 0030067322     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.jbchem.a021244     Document Type: Article

References (38)

1. Liotta, L.A., Steeg, P.S., and Stetler-Stevenson, W.G. (1991) Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation. Cell 64, 327-336
2. Stetler-Stevenson, W.G., Aznavoorian, S., and Liotta, L.A. (1993) Tumor cell interactions with the extracellular matrix during invasion and metastasis. Annu. Rev. Cell Biol. 9, 541-573
3. Woessner, J.F., Jr. (1991) Matrix metalloproteinases and their inhibitors in connective tissue remodeling. FASEB J. 5, 2145-2154
4. Quax, P.H.A., van Leeuwen, R.T.J., Verspaget, H.W., and Verheijen, J.H. (1990) Protein and messenger RNA levels of plasminogen activators and inhibitors analyzed in 22 human tumor cell lines. Cancer Res. 50, 1488-1494
5. Miyagi, E., Yasumitsu, H., Hirahara, F., Minaguchi, H., Koshikawa, N., Miyazaki, K., and Umeda, M. (1995) Characterization of matrix-degrading proteinases and their inhibitors secreted by human gynecological carcinoma cells. Jpn. J. Cancer Res. 86, 568-576
6. Koshikawa, N., Yasumitsu, H., Umeda, M., and Miyazaki, K. (1992) Multiple secretion of matrix serine proteinases by human gastric carcinoma cell lines. Cancer Res. 52, 5046-5053
7. Koshikawa, N., Yasumitsu, H., Nagashima, Y., Umeda, M., and Miyazaki, K. (1994) Identification of one-chain and two-chain forms of trypsinogen 1 produced by a human gastric adenocarcinoma cell line. Biochem. J. 303, 187-190
8. Hirahara, F., Miyagi, Y., Miyagi, E., Yasumitsu, H., Koshikawa, N., Nagashima, Y., Kitamura, H., Minaguchi, H., Umeda, M., and Miyazaki, K. (1995) Trypsinogen expression in human ovarian carcinomas. Int. J. Cancer 63, 176-181
9. Koivunen, E., Saksela, O., Itkonen, O., Osman, S., Huhtala, M.-L., and Stenman, U.-H. (1991) Human colon carcinoma, fibrosarcoma and leukemia cell lines produce tumor-associated trypsinogen. Int. J. Cancer 47, 592-596
10. Okada, Y., Gonoji, Y., Naka, K., Tomita, K., Nakanishi, I., Iwata, K., Yamashita, K., and Hayakawa, T. (1992) Matrix metalloproteinase 9 (92-kDa gelatinase/Type IV collagenase) from HT 1080 human fibrosarcoma cells. J. Biol. Chem. 267, 21712-21719
11. Miyazaki, K., Hasegawa, M., Funahashi, K., and Umeda, M. (1993) A metalloproteinase inhibitor domain in Alzheimer amyloid protein precursor. Nature 362, 839-841
12. Miyazaki, K., Funahashi, K., Numata, Y., Koshikawa, N., Akaogi, K., Kikkawa, Y., Yasumitsu, H., and Umeda, M. (1993) Purification and characterization of a two-chain form of tissue inhibitor of metalloproteinases (TIMP) type 2 and a low molecular weight TIMP-like protein. J. Biol. Chem. 268, 14387-14393
13. Hanspal, J.S., Bushell, G.R., and Ghosh, P. (1983) Detection of protease inhibitors using substrate-containing sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Anal. Biochem. 132, 288-293
14. Miyagi, Y., Koshikawa, N., Yasumitsu, H., Miyagi, E., Hirahara, F., Aoki, I., Misugi, K., Umeda, M., and Miyazaki, K. (1994) cDNA cloning and mRNA expression of a serine proteinase inhibitor secreted by cancer cells: Identification as placental protein 5 and tissue factor pathway inhibitor-2. J. Biochem. 116, 939-942
15. Weidemann, A., Konig, G., Bunke, D., Fischer, P., Salbaum, J.M., Masters, C.L., and Beyreuther, K. (1989) Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein. Cell 57, 115-126
16. Ashall, F. and Goate, A.M. (1994) Role of the β-amyloid precursor protein in Alzheimer's disease. TIBS 19, 42-46
17. Oltersdorf, T., Fritz, L.C., Schenk, D.B., Lieberburg, I., Johnson-Wood, K.L., Beattie, E.C., Ward, P.J., Blacher, R.W., Dovey, H.F., and Sinha, S. (1989) The secreted form of the Alzheimer's amyloid precursor protein with the Kunitz domain is protease nexin-II. Nature 341, 144-147
18. Von Nostrand, W.E., Wagner, S.L., Suzuki, M., Choi, B.H., Farrow, J.S., Geddes, J.W., Cotman, C.W., and Cunningham, D.D. (1989) Protease nexin-II, a potent antichymotrypsin, shows identity to amyloid β-protein precursor. Nature 341, 546-549
19. Itoh, H., Kataoka, H., Koita, H., Nabeshima, K., Inoue, T., Kangawa, K., and Koono, M. (1991) Establishment of a new human cancer cell line secreting protease nexin-II/amyloid β protein precursor derived from squamous-cell carcinoma of lung. Int. J. Cancer 49, 436-443
20. Kataoka, H., Seguchi, K., Iwamura, T., Moriyama, T., Nabeshima, K., and Koono, M. (1995) Reverse-zymographic analysis of protease nexin-II/amyloid β protein precursor of human carcinoma cell lines, with special reference to the grade of differentiation and metastatic phenotype. Int. J. Cancer 60, 123-128
21. Wun, T.C., Kretzmer, K.K., Girard, T.J., Miletich, J.P., and Broze, G.J., Jr. (1988) Cloning and characterization of a cDNA coding for the lipoprotein-associated coagulation inhibitor shows that it consists of three tandem Kunitz-type inhibitory domains. J. Biol. Chem. 263, 6001-6004
22. Broze, G.J., Jr., Girard, T.J., and Novotny, W.F. (1990) Regulation of coagulation by a multivalent Kunitz-type inhibitor. Biochemistry 29, 7539-7544
23. Bützow, R., Huhtala, M.L., Bohn, H., Virtanen, I., and Seppälä, M. (1988) Purification and characterization of placental protein 5. Biochem. Biophys. Res. Commun. 150, 484-490
24. Rosen, S.W. (1986) New placental proteins: Chemistry, physiology and clinical use. Placenta 7, 575-594
25. Bützow, R., Virtanen, I., Seppälä, M., Narvanen, O., Stenman, U.-H., Ristimaki, A., and Bohn, H. (1988) Monoclonal antibodies reacting with placental protein 5: Use in radioimmunoassay, western blot analysis, and immunohistochemistry. J. Lab. Clin. Med. 111, 249-256
26. Sprecher, C.A., Kisiel, W., Mathewes, S., and Foster, D.C. (1994) Molecular cloning, expression and partial characterization of a novel human tissue factor pathway inhibitor. Proc. Natl. Acad. Sci. USA 91, 3353-3357
27. Thompson, R.C. and Ohlsson, K. (1986) Isolation, properties, and complete amino acid sequence of human secretory leukocyte protease inhibitor, a potent inhibitor of leukocyte elastase. Proc. Natl. Acd. Sci. USA 83, 6692-6696
28. Lucey, E.C., Stone, P.J., Ciccolella, D.E., Breuer, R., Christensen, T.G., Thompson, R.C., and Snider, G.L. (1990) Recombinant human secretory leukocyte-protease inhibitor: In vitro properties, and amelioration of human neutrophil elastase-induced emphysema and secretory cell metaplasia in the hamster. J. Lab. Clin. Med. 115, 224-232
29. 1-antitrypsin secreted by human adenocarcinoma cell lines. FEBS Lett. 328, 291-295
30. Heidtmann, H.-H., Hofmann, M., Jacob, E., Erbil, C., Havemann, K., and Schwaetz-Albiez, R. (1989) Synthesis and secretion of plasminogen activators and plasminogen activator inhibi-tors in cell lines of different groups of human lung tumors. Cancer Res. 49, 6960-6965
31. McKeehan, W.L., Sakagami, Y., Hoshi, H., and McKeehan, K.A. (1986) Two apparent human endothelial cell growth factors from human hepatoma cells are tumor-associated proteinase inhibitors. J. Biol. Chem. 261, 5378-5383
32. Saitoh, T., Sundsmo, M., Roch, J.-M., Kimura, N., Cole, G., Schubert, D., Oltersdorf, T., and Schenk, D.B. (1989) Secreted form of amyloid β protein precursor is involved in the growth regulation of fibroblasts. Cell 58, 615-622
33. Chen, M. and Yunkner, B.A. (1991) An antibody to β amyloid and the amyloid precursor protein inhibits cell-substratum adhesion in many mammalian cell types. Neurosci. Lett. 125, 223-226
34. Ogawa, M., Tsushima, T., Ohbu, Y., Ogawa, N., Tanaka, S., Ishida, M., and Mori, T. (1985) Stimulation of DNA synthesis in human fibroblasts by human pancreatic secretory trypsin inhibitor. Res. Commun. Chem. Pathol. Pharmacol. 50, 155-158
35. Perry, J.K., Scott, G.K., and Tse, C.A. (1994) Modulation of proliferation of cultured human cells by urinary trypsin inhibitor. Biochim. Biophys. Acta 1221, 145-152
36. Hayakawa, T., Yamashita, K., Tanzawa, K., Uchijima, E., and Iwata, K. (1992) Growth-promoting activity of tissue inhibitor of metalloproteinases-1 (TIMP-1) for a wide range of cells. FEBS Lett. 298, 29-32
37. Banda, M.J., Rice, A.G., Griffin, G.L., and Senior, R.M. (1988) Alpha-1-proteinase inhibitor is a neutrophil chemoattractant after proteolytic inactivation by macrophage elastase. J. Biol. Chem. 263, 4481-4484
38. Monard, D. (1988) Cell-derived proteases and protease inhibitors as regulators of neurite outgrowth. TINS 11, 541-544