Immunosuppressive effects of endotoxins and bile acids in vivo in the rat

European Journal of Clinical Investigation

Volumn 26, Issue 1, 1996, Pages 45-48

  Aouad, K ^a   Calmus, Y ^b   Nordlinger, B ^a   Myara, A ^c   Weill, B ^b   Poupon, R ^a  

^a HÔPITAL SAINT ANTOINE   (France)

^b Université Paris Descartes   (France)

^c SAINT JOSEPH HOSPITAL   (France)

Author keywords

Bile acids; Cholestasis; Endotoxins; Immunodeficiency

Indexed keywords

BILE ACID; ENDOTOXIN;

ANIMAL EXPERIMENT; ARTICLE; CHOLESTASIS; CONTROLLED STUDY; IMMUNE DEFICIENCY; IMMUNOSUPPRESSIVE TREATMENT; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0030067286     PISSN: 00142972     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2362.1996.95240.x     Document Type: Article

References (22)

1. Armstrong CP, Dixon JM, Taylor TV, Davies GC. Surgical experience of deeply jaundiced patients with bile duct obstruction. Br J Surg 1984;71:234-8.
2. Cainzos M, Potel J, Puente JL. Anergy in jaundiced patients. Br J Surg 1988;75:147-9.
3. Feduccia TD, Scott-Conner CEH, Grogan JB. Profound suppression of lymphocyte function in early biliary obstruction. Am J Med Sci 1988;31:39-44.
4. Calmus Y, Weill B, Ozier Y, Chéreau C, Houssin D, Poupon R. Immunosuppressive properties of chenodeoxycholic and ursodeoxycholic acids in the mouse. Gastroenterology 1992; 103:617-21.
5. Roughneen PT, Druth DB, Kulkarni AD, Rowlands BJ. Impaired nonspecific cellular immunity in experimental cholestasis. Ann Surg 1987;206:578-82.
6. Roughneen PT, Didlake R, Kumar SC, Kahan BD, Rowlands BJ. Enhancement of heterotopic cardiac allograft survival by experimental biliary ligation. Transplantation 1987;43:437-8.
7. Roughneen PT, Gouma DJ, Kulkarni AD, Fanslow WF, Rowlands BJ. Impaired cell-mediated immunity in experimental biliary obstruction and its reversibility by internal biliary drainage. J Surg Res 1986;41:113-25.
8. Roughneen PT, Gouma DJ, Kulkarni AD, Fanslow WF, Rowlands BJ, Suppression of host-versus-graft response in experimental biliary obstruction. Transplantation 1986;42:687-9.
9. Greve JW, Gouma DJ, Soeters PB, Buurman WA. Suppression of cellular immunity in obstructive jaundice is caused by endotoxins: A study with germ-free rats. Gastroenterology 1990;98: 478-85.
10. Calmus Y, Guéchot J, Bonnefis MT, Giboudeau J, Poupon R. Differential effects of chenodeoxycholic and ursodeoxycholic acids on IL1, IL6 and TNF productions. Hepatology 1992;16: 719-23.
11. Ono K, Lindsey L. Improved technique of heart transplantation in rats. J Thorac Cardiovasc Surg 1969;57:225-8.
12. Labbé D, Gerhardt MF, Myara A, Vercambre C, Trivin F. High performance liquid chromatographic determination of tauro-and glyco-conjugated bile acids in human serum. J Chromatogr 1989;490:275-84.
13. Gouma DJ, Roughneen PT, Kumar CB, Moody FG, Rowlands BJ. Changes in nutritional status associated with obstructive jaundice and biliary drainage in rats. Am J Clin Nutr 1986;44:362-9.
14. Van Bossuyt H, Desmaretz C, Gaeta GB, Wisse E. The role of bile acids in the development of endotoxemia during obstructive jaundice in the rat. J Hepatol 1990;10:274-9.
15. Haslewood GAD. The Biological Importance of Bile Salts. Elsevier/North Holland Publishing Company, Amsterdam, 1978.
16. Yosikawa M, Tsujii T, Matsumura K, et al. Immunomodulatory effects of ursodeoxycholic acid on immune responses. Hepatology 1992;16:358-64.
17. Stiehl A. Disturbances of bile acid metabolism in cholestasis. In: Paumgartner G, ed. Clinics in Gastroenterology. Bile Acids, London: WB Saunders, 1977:45-89.
18. Nathan CF. Secretory products of macrophage. J Clin Invest 1987;79:319-25.
19. Gérard C, Bruyns C, Marchant A, et al. Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia. J Exp Med 1993;177:547-50.
20. Durez P, Abramowicz D, Gérard C, et al. In vivo induction of interleukin 10 by anti-CD3 monoclonal antibody or bacterial lipopolysaccharide : Differential modulation by cyclosporin A. J Exp Med 1993;177:551-5.
21. Fiorentino DF, Zlotnik A, Mosmann TR, Howard M, O'Garra A. IL-10 inhibits cytokine production by activated macrophages. J Immunol 1991;147:3815-21
22. Persson U. Lipopolysaccharide-induced suppression of the primary immune response to a thymus-dependent antigen. J Immunol 1977;118:789.