Preventive effect of atropine on indomethacin-lnduced gastrointestinal mucosal and vascular damage in rats

Pharmacology

Volumn 52, Issue 1, 1996, Pages 46-55

  Karadi O ^a   Abdel Salam, O M E ^a   Bodis B ^a   Mozsik G ^a  

^a UNIVERSITY OF PÉCS   (Hungary)

Author keywords

Atropine; Gastrointestinal mucosal ulcerations; Indomethacin; Vascular permeability

Indexed keywords

ATROPINE; EVANS BLUE; INDOMETACIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL INJURY; BLOOD VESSEL PERMEABILITY; COLON; CONTROLLED STUDY; DIGESTIVE SYSTEM ULCER; DOSE RESPONSE; GASTROINTESTINAL MUCOSA; INTRAPERITONEAL DRUG ADMINISTRATION; NONHUMAN; PRIORITY JOURNAL; RAT; SMALL INTESTINE; STOMACH; SUBCUTANEOUS DRUG ADMINISTRATION; VAGOTOMY;

EID: 0030066796     PISSN: 00317012     EISSN: 14230313     Source Type: Journal    
DOI: 10.1159/000139360     Document Type: Article

References (31)

1. Karadi O, Mozsik Gy., Kiraly A., Siito G., Vincze A.: Surgical vagotomy enhances the indomethacin-induced gastrointestinal mucosal damage in rats., Inflammopharma-cology 1994;2:389-399.
2. Mozsik Gy., Kirdly A., Garamszegi M., Jdvor T., Nagy L., Suto G., Toth Gy., Vincze A.; Failure of prostacyclin, 3-carotene, atropine and cimet-idinc to produce gastric cyto-and general mucosal protection in surgically vagotomized rats., Life Sci 1991;49:1383-1389.
3. Grijalva CV, Novin D: The role of the hypothalamus and dorsal vagal complex in gastrointestinal function and pathophysiology., Ann NY Acad Sci 1990;597:207-221.
4. Gabella G, Pease HL: Number of axons in the abdominal vagus of the rat., Brain Res 1973;58:465-469.
5. Takcuchi K, Ueshima K, Hironaka Y, Fujioka Y, Matsumoto J, Okabe S: Oxygen free radicals and lipid peroxidation in the pathogenesis of gastric mucosal lesions induced by indomethacin in rats: Relation to gastric hypermotility., Digestion 1991;49:175-184.
6. Quijano RF., Ohnishi N, Umeda K., Komada F, Iwakawa S, Okumira K: Effect of atropine on gastrointestinal motility and the bioavailability of cyclosporine A in rats., Drug Metab Dispos Biol Fate Chem 1993,21: 141-143.
7. Oda M, Nakamura M, Honda K, Komatsu H, Kancko K, Azuma T, Nishizaki Y, Tsuchiya M: Involvement of autonomic nervous system in gastric mucosal defense mechanism., J Clin Gastroenterol 1988:10 (suppl 1):S99-S113.
8. Gurbindo C, Russo P, Sabbah S, Lo-houes MJ., Seidman E: Intcrlcukin-2 activity of colonic lamina propria mononuclear cells in a rat model of experimental colitis., Gastroenterology 1993;104:964-972.
9. Bumstock G: The purinergic nervous system., Pharmacol Rev 1972; 24:509-581.
10. Mozsik Gy., Moron F., Fiegler M., Javor T., Nagy L, Patty I, Tamok F.: Membrane-bound ATP-dependent energy systems and gastric cytopro-tection by prostacyclin, atropine and cimetidine in the rat., Int J Tiss Reac 1983;5:263-278.
11. Siito G, Kirdly A, Vincze A, Jdvor T, Mozsik Gy: A new computer assisted method to determine the area of mucosal lesions in the stomach induced by chemicals in rats., Z Gastroenterol 1991;29:205-206.
12. Brodie DA, Cook PG, Bauer BJ: In-domethacin-induced intestinal lesions in the rat., Toxicol Appl Pharmacol 1970;17:615-624.
13. Djahanguiri B: The production of acute gastric ulceration by indomethacin in the rat., Scand J Gastroenterol 1969;4:265-267.
14. Lowry OH, Rosebrough NJ., Farr AL, Randall RJ: Protein measurement with the Folin phenol reagent., J Biol Chem 1951;193:265-275.
15. Szabo S., Trier JS., Brown A., Schnoor J.: Early vascular injury and increased vascular permeability in gastric mucosal injury caused by ethanol in the rat., Gastroenterology 1985;88:228-236.
16. Miller TA, Jacobson ED: Gastrointestinal cytoprotection by prostaglandins., Gut 1979;20:75-87.
17. Weiner N: Atropine, scopolamine and related antimuscarinic drugs; in Goodman-Gilman A, Goodman LS, Gilman A (eds): The pharmacological basis of therapeutics., New York, Macmillan Publishing Co, 1980, pp 120-137.
18. Wallace JL, Keenan CM, Granger DN: Gastric ulceration induced by nonsteroidal anti-inflammatory drugs is a neutrophil-dependent process., Am J Physiol 1990;259:G462-G467.
19. Whittle BJR: Temporal relationship between cyclooxygenase inhibition, as measured by prostacyclin biosynthesis, and the gastrointestinal damage induced by indomethacin in the rat., Gastroenterology 1981:80:94-98.
20. Mozsik Gy., Moron F., Javor T: Cellular mechanisms of the development of gastric mucosal damage and of gastrocytoprotection induced by prostacyclin in rats: A pharmacological study., Prostagl Leucot Med 1982;9:71-84.
21. Mozsik Gy, Karadi O, Kiraly A, Ma-tus Z, Siito G., Toth Gy, Vincze A: Vagal nerve and the gastric mucosal defense., J Physiol (Paris) 1993;87: 329-334.
22. Kauffmann GL, Aures JRD, Gross-man MJ: Intravenous indomethacin and aspirin reduce basal gastric mucosal blood flow in dogs., Am J Physiol 1980;238:G131-G134.
23. Altschuler SM, Escardo J., Lynn RB, Miselis RR: The central organization of the vagus nerve innervating the colon of the rat., Gastroenterology 1993;104:502-509.
24. Berthoud HR, Neuhuber WL: Distribution and morphology of vagal afferents and efferents supplying the digestive system; in Tache Y, Wingate DL, Burks TF (eds): Innervation of the Gut., Pathophysiological Implications., Boca Raton., CRC Press, 1994, pp 39-61.
25. Percdo HA, Enero MA: Effect of endothelium removal on basal and muscarinic cholinergic stimulated rat mesenteric vascular bed prostanoid synthesis., Prostaglandins Leu-kotrienes Essent Fatty Acids 1993; 48:373-378.
26. Mozsik Gy., Kiralv A., Siito G., Vincze A.: ATP breakdown and resynthesis in the development of gastrointestinal mucosal damage and its prevention in animals and human., Acta Physiol Hung 1992:80: 39-80.
27. Mozsik Gy., Siito G, Vincze A: Correlations between the acute chemical and surgical vagotomy-induced gastric mucosal biochemistry in rats., J Clin Gastroenterol 1992;14(suppl 2):S135-S139.
28. Schneider HTh, Nuernberg B., Diet-zel K, Domschke W, Brune K: Biliary elimination of non-steroidal antiinflammatory drugs in patients with bile duct tubes., Gastroenterology 1989;96:A656.
29. Siito G, KirSly A, Vincze A, Mdzsik Gy; Effect of acute surgical vagotomy on the mucosal content of 6-kcto-PGFia, PGE2 and glutathione after intragastric 96% ethanol treatment in rats., Acta Physiol Hung 1992;80:205-211.
30. Burakoff R, Nastos E, Won S: Effects of PGF2 alpha and of indomethacin on rabbit small and large intestinal motility in vivo., Am J Physiol 1990;258:G231-G237.
31. Gamse R, Holzer P, Lembeck F: Decrease of substance P in primary afferent neurones and impairment of neurogenic plasma extravasation by capsaicin., Br J Pharmacol 1980;68: 207-213.