Myocardium-protective effects of Ginkgo biloba extract (EGb 761) in old rats against acute isobaric hypoxia. An electron microscopic morphometric study. I. Protection of cardiomyocytes

Experimental and Toxicologic Pathology

Volumn 48, Issue 1, 1996, Pages 33-39

  Fitzl, G ^a   Welt, K ^a   Schaffranietz, L ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Ginkgo biloba extract; Hypoxia; Myocardium; Myocardium, hypoxia

Indexed keywords

GINKGO BILOBA EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HEART MUSCLE CELL; HYPOXIA; MALE; MORPHOMETRICS; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; ULTRASTRUCTURE;

EID: 0030066767     PISSN: 09402993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0940-2993(96)80089-3     Document Type: Article

References (19)

1. BEYERSDORF F, ZIMMER G, FUCHS J et al.: Improvement of myocardial function after global hypoxia by protection of the inner mitochondrial membrane. ArzneimForsch/Drug Res 1987; 37: 142-149.
2. CLOSTRE F: From the body to the cellular membranes. In: FUNFGELD EW (ed.): The different levels of pharmacological action of Ginkgo biloba extract. Rökan (Ginkgo biloba), Recent Results in Pharmacology and Clinic. Springer Verlas Berlin Heidelberg New York 1988, pp. 180-198.
3. COSTA LE, BOVERIS OR, KOCH AC et al.: Liver and heart mitochondria in rats submitted to chronic hypobaric hypoxia. Amer J Physiol 1988; 255: 123-129.
4. DAVID H, SCHUBEL B, WARNKE H et al.: Elektronenmikroskopische Befunde der Herzmuskulatur beim Morbus Fallot und Ventrikelseptumdefekt. Zbl Allg Pathol und Pathol Anat 178; 122: 34-42.
5. DöRING V, BLEESE N, GERKEN G, et al.: Stoffwechsel und elektronenmikroskopische Feinstruktur. Magnesium-Aspartal-Procain-stillgelegtes Menschen- und Kaninchenherz. Thoraxchir (Stuttgart) 1975; 23: pp. 309-313.
6. FITZL G, WELT K, SCHAFFRANIETZ L, et al.: Ultrastrukturelle Reaktionen der Kardiomyozyten von Ratte und Hund auf experimentelle Hypoxie und Ischämie. Verh Anat Ges 1992; Suppl 174: 29.
7. FREISLEBEN H-J, KRIEGE H, CLARKE C et al.: Hemodynamic and mitochondrial parameters during hypoxia and reoxygenation in workins rat hearts. Arzneim-Forsch/ Drug Res 1991; 41: 81-88.
8. 2-Radikale) bei Hypoxie und Ischämie. Z Klin Med 1987; 42: 1025-1029.
9. GUILLON JM, ROCHETTE L, BARANES J: Effects of Ginkgo biloba extract on two models of experimental myocardial ischemia. In: FUNFGELD EW (ed.): Rökan (Ginkgo biloba). Recent Results in Pharmacology and Clinic. Springer-Verlag Berlin Heidelbers New York 1988, pp. 153-161.
10. HARAMAKI N, NGUYEN L, AZIZ T, et al.: Ginkgo biloba extract (EGb 761) protects against myocardial ischemiareperfusion injury by acting as an antioxidant. In: CLOSTRE F, DE FEUDIS FV (eds.): Advances in Ginkgo biloba Extract Research Vol 3, Cardiovascular effects of Ginkgo biloba Extract; Elsevier, Paris 1994, pp. 59-68.
11. HUANG Z, CHEN S, ZHANG G, et al.: Protective effects of berberine and phentolamine on myocardial reoxygenation damage. Chin Med Sci J 1992; 7: 221-225.
12. JENNINGS RB, MURRY CE, STEENBERGEN C Jr.: Development of cell injury in sustained acute ischemia. Circulation 1990, 82: Suppl. 3: 112.
13. PUNKT K, WELT K, SCHAFFRANIETZ L: Changes of enzyme activities in the rat myocardium caused by experimental hypoxia with and without Ginkgo biloba extract EGb 761-pretreatment. A cytophotometrical study. Acta histochem 1995; 97: 67-79.
14. REMACLE J, HOUBION A, ALEXANDRE I, et al.: Behavior of human endothelial cells in hyperoxia and hypoxia: effect of Ginkor Fortschr/Phlebologie 1990; 43: 375-386.
15. SCHAPER J, MULCH J, WINKLER B, et al.: Ultrastructural, functional and biochemical criteria for estimation of reversibility of ischemic injury: a study on the effects of global ischemia on the isolated dog heart. J mol Cell Cardiol 1979; 11: 521-541.
16. SCHAPER J, SCHWARZ H, KITTSTEIN G, et al.: The effects of global ischemia and reperfusion on human myocardium: quantitative evaluation by electron microscopy. Ann Thoracic Surg 1982; 33: 115-122.
17. SPIECKERMANN PG: Überlebens- und Wiederbelebungszeit des Herzens. Anaesthesiol u. Wiederbeleb 1973; 66: 2-6.
18. TOROK B, ROTH E, MATKOVICS B: Myocardial injuries mediated by free oxygen radicals. Acta Physiol Huns 1986; 68: 25-31.
19. WEBSTER KA, DISCHER DJ, BISHOPRIC NH: Induction and nuclear accumulation of fos and jun proto-oncogenes in hypoxic cardiac myocytes. J Biol Chem 1993; 268: 16852-16858.