Effects of the anti-gastric secretory drugs IT-066 and omeprazole on mitogenic activities in the gastric juice of the rat

Scandinavian Journal of Gastroenterology

Volumn 31, Issue 2, 1996, Pages 111-117

  Kasugai, K ^b   Joh, T ^b   Kataoka, H ^b   Kato, T ^b   Itoh, M ^a  

^a NAGOYA CITY UNIV MEDICAL SCHOOL   (Japan)

^b NONE

Author keywords

Epidermal growth factor; Gastric juice; Growth factor; H2 receptor antagonist; Mitogenic activity; Peptic ulcer; Proton pump inhibitor; Stomach

Indexed keywords

EPIDERMAL GROWTH FACTOR; HISTAMINE H2 RECEPTOR ANTAGONIST; OMEPRAZOLE; PIBUTIDINE; PROTON PUMP; PROTON PUMP INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; HUMAN; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MITOGENESIS; PEPTIC ULCER; PRIORITY JOURNAL; RAT; STOMACH JUICE;

EID: 0030066738     PISSN: 00365521     EISSN: None     Source Type: Journal    
DOI: 10.3109/00365529609031973     Document Type: Article

References (30)

1. Murphy RA, Pantazis NJ, Papastavros M. Epidermal growth factor and nerve growth factor in mouse saliva: a comparative study. Dev Biol 1979;71:356-70.
2. Humphreys BM, Macauley SP, Chegini N, Setten G, Purushotham K, Stewart C, et al. Characterization of the synthesis and secretion of transforming growth factor-alpha from salivary glands and saliva. Endocrinology 1994;134:963-70.
3. Yeh YC, Guh JY, Yeh J, Yeh HW. Transforming growth factor type alpha in normal human adult saliva. Mol Cell Endocrinol 1989;67:247-55.
4. Costigan DC, Guyda HJ, Posner BI. Free insulin-like growth factor I (IGF-I) and IGF-II in human saliva. J Clin Endocrinol Metab 1988;66:1014-8.
5. Gregory H, Walsh S, Hopkins CR. The identification of urogastrone in serum, saliva, and gastric juice. Gastroenterology 1979;77:313-8.
6. Konturek SJ, Brzozowski T, Piastucki I, Dembinski A, Radecki T, Dembinska KA, et al. Role of mucosal prostaglandins and DNA synthesis in gastric cytoprotection by luminal epidermal growth factor. Gut 1981;22:927-32.
7. Kirkegaard P, Olsen PS, Poulsen SS, Nexo E. Epidermal growth factor inhibits cysteamine-induced duodenal ulcers. Gastroenterology 1983;85:1277-83.
8. Olsen PS, Poulsen SS, Kirkegaard P, Nexo E. Role of submandibular saliva and epidermal growth factor in gastric cytoprotection. Gastroenterology 1984;87:103-8.
9. Itoh M, Imai S, Joh T, Kawai T, Katsumi K, Yokochi K, et al. Protection of gastric mucosa against ethanol-induced injury by intragastric bolus administration of epidermal growth factor combined with hydroxypropylcellulose. J Clin Gastroenterol 1992;14 Suppl 1:S127-30.
10. Joh T, Itoh M, Katsumi K, Yokoyama T, Miyamoto T, Imai S, et al. Immunoreactive epidermal growth factor in mouse digestive organs. Use of a sensitive enzyme immunoassay. Acta Endocrinol (Copenh) 1987;115:203-10.
11. Joh T, Itoh M, Yasue N, Miyamoto T, Iwai A, Matsusako K, et al. A sensitive enzyme immunoassay system of rat epidermal growth factor in biological fluids and tissue extracts. Acta Endocrinol (Copenh) 1989;120:616-23.
12. Barka T. Biologically active polypeptide in submandibular glands. J Histochem Cytochem 1980;28:836-59.
13. Murphy RA, Watson AY, Metz J, Forssmann WG. The mouse submandibular gland: an exocrine organ for growth factors. J Histochem Cytochem 1980;28:890-902.
14. Hutson JM, Niall M, Evans D, Fowler R. Effect of salivary glands on wound contraction in mice. Nature 1979;279:793-5.
15. Li AKC, Koroly MJ, Schattenkerk ME, Malt RA, Young M. Nerve growth factor: acceleration of the rate of wound healing in mice. Proc Natl Acad Sci USA 1980;77:4379-81.
16. Noguchi S, Ohba Y, Oka T. Effect of salivary epidermal growth factor on wound healing of tongue in mice. Am J Physiol 1991;260:E620-5.
17. Carpenter G, Cohen S. Epidermal growth factor. Ann Rev Biochem 1979;48:193-216.
18. Konturek JW, Bielanski W, Konturek SJ, Bogdal J, Oleksy J. Distribution and release of epidermal growth factor in man. Gut 1989;30:1194-200.
19. Konturek SJ, Dembinski A, Warzecha Z, Brzozowski T, Gregory H. Role of epidermal growth factor in healing of chronic gastroduodenal ulcers in rats. Gastroenterology 1988; 94:1300-7.
20. Olsen PS, Poulsen SS, Therkelsen K, Nexo E. Oral administration of synthetic human urogastrone promote healing of chronic duodenal ulcers in rats. Gastroenterology 1986;90:911-7.
21. Britton JR, George NC, Koldovsky O. Luminal hydrolysis of recombinant human epidermal growth factor in the rat gastrointestinal tract: segmental and developmental differences. Life Sci 1988;43:1339-47.
22. Britton JR, George NC, Udall JN, Koldovsky O. Minimal hydrolysis of epidermal growth factor by gastric fluid of preterm infants. Gut 1989;30:327-32.
23. Schaudies RP, Grimes J, Davis D, Rao RK, Koldovsky O. EGF content in the gastrointestinal tract of rats: effect of age and fasting/feeding. Am J Physiol 1989;256:G856-61.
24. Hock RA, Hollenberg MD. Characterization of the receptor for epidermal growth factor-urogastrone in human placenta membranes. J Biol Chem 1980;255:10731-6.
25. Playford RJ, Woodman AC, Clark P, Watanapa P, Vesey D, Deprez PH, et al. Effect of luminal growth factor preservation on intestinal growth. Lancet 1993;341:843-8.
26. Playford RJ, Marchbank T, Calnan DP, Calam J, Royston P, Batten JJ, et al. Epidermal growth factor is digested to smaller, less active forms in acidic gastric juice. Gastroenterology 1995;108:92-101.
27. Folkmann J, Szabo S, Stovroff M, Mcneil P, Li W, Shing Y. Duodenal ulcer: discovery of a new mechanism and development of angiogenic therapy that accelerates healing. Ann Surg 1991;214:414-27.
28. 2-receptor antagonist: ebrotidine. Digestion 1992;51:27-36.
29. Wright NA, Pike C, Elia G. Induction of a novel epidermal growth factor-secreting cell lineage by mucosal ulceration in human gastrointestinal stem cells. Nature 1990;343:82-5.
30. Konturek SJ. Role of growth factors in gastroduodenal protection and healing of peptic ulcers. Gastroenterol Clin North Am 1990;19:41-65.