Comparative evaluation of chelating agents on the mobilization of cadmium: A mechanistic approach

Journal of Toxicology and Environmental Health

Volumn 47, Issue 2, 1996, Pages 173-182

  Srivastava, R C ^a,b   Gupta, Sanjay ^a   Ahmad, Nihal ^a   Hasan, S K ^a   Farookh, A ^a   Husain, M M ^a  

^a CSIR INDIAN INSTITUTE OF TOXICOLOGY RESEARCH   (India)

^b U S DEPARTMENT OF AGRICULTURE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,4,8,12 TETRAAZACYLOPENTADECANE; CADMIUM; CHELATING AGENT; CYCLAM; DIETHYLDITHIOCARBAMIC ACID; DIMETHYLDITHIOCARBAMIC ACID; SUCCIMER; UNCLASSIFIED DRUG; UNITHIOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; INTOXICATION; INTRAPERITONEAL DRUG ADMINISTRATION; KIDNEY; LD 50; LIPOPHILICITY; LIVER; MOBILIZATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SURVIVAL;

ANIMALS; CADMIUM; CHELATING AGENTS; DIMETHYLDITHIOCARBAMATE; FEMALE; LETHAL DOSE 50; MICE; SOLUBILITY; SUCCIMER; TISSUE DISTRIBUTION; UNITHIOL;

ANIMALIA;

EID: 0030065977     PISSN: 00984108     EISSN: None     Source Type: Journal    
DOI: 10.1080/009841096161870     Document Type: Article

References (24)

1. Anderson, O. 1989. Oral cadmium exposure in mice: Toxicokinetics and efficiency of chelating agents. Crit. Rev. Toxicol. 20:83-112.
2. Anderson, O., Nielsen, J. B., and Svendsen, P. 1988. Oral cadmium chloride intoxication in mice: Diethyldithiocarbamate enhances rather than alleviates acute toxicity. Toxicology 52:331-342.
3. Athar, M., Misra, M., and Srivastava, R. C. 1987. Evaluation of chelating drugs on the toxicity, excretion and distribution of nickel in poisoned rats. Fundam. Appl. Toxicol. 9:26-33.
4. Behari, J. R., Gupta, S., Srivastava, S., and Srivastava, R. C. 1990. Use of liposome encapsulated 2,3-dimercaptopropane sulfonate (DMPS) in the treatment of mice loaded with cadmium. J. Environ. Sci. Health 25(6):597-610.
5. Behari, J. R., Srivastava, S., Gupta, S., and Srivastava, R. C. 1991. Effect of liposome encapsulated meso -2,3-dimercapto succinic acid (DMSA) on biochemical and trace metal alterations in cadmium exposed rats. Bull. Environ. Contam. Toxicol. 47:827-833.
6. Cantilena, L. R., and Klaassen, C. D. 1981. Comparison of the effectiveness of several chelators after single administration on the toxicity, excretion and distribution of cadmium. Toxicol. Appl. Pharmacol. 58:452-460.
7. Daniel, W. W. 1978. Simple linear regression and correlation. In Biostatistics: A foundation for analysis in health science, 2nd ed., pp. 254-301. New York: Wiley.
8. Gale, G. R., Atkin, L. M., Smith, A. P., Singh, P. K., and Jones, M. M. 1989. N, N-Disubstituted dithio-carbamates as cadmium antagonists. N-(4-Methoxybenzyl) N-dithiocarboxy D-glucamine. Toxicol. Lett. 48:105-115.
9. Jasim, S., and Tjalve, H. 1984. Effect of thiuram sulphides on the uptake and distribution of nickel in pregnant and non-pregnant mice. Toxicology 32:297-313.
10. Jones, M. M. 1991. New developments in therapeutic chelating agents as antidotes for metal poisoning. Crit. Rev. Toxicol. 21:209-233.
11. Jones, S. G., Jones, M. M., Basinger, M. A., Burka, L. T., and Shinobu, L. A. 1983. Polarity and antidotal efficacy of dithiocarbamates in acute cadmium intoxication. Res. Commun. Chem. Pathol. 40:155-164.
12. Jones, M. M., Singh, P. K., Gale, G. R., Atkins, L. M., and Smith, A. B. 1988a. Esters of meso-dimercap-tosuccinic acid as cadmium mobilizing agents. Toxicol. Appl. Pharmacol. 95:507-574.
13. Jones, S. G., Singh, P. K., and Jones, M. M. 1988b. Use of the Topliss scheme for the design of more effective chelating agents for cadmium decorporation. Chem. Res. Toxicol. 1:234-237.
14. Jones, M. M., Singh, P. K., Basinger, M. A., Gale, G. R., Smith, A. B., and Harris, W. R. 1994a. Design of in vivo cadmium mobilizing agents: Synthesis and properties of monobenzyl meso-2,3-dimercap-tosuccinate. Chem. Res. Toxicol. 7:367-374.
15. Jones, M. M., Singh, P. K., Basinger, M. A., Galo, G. R., and Smith, A. B. 1994b. Cadmium mobilization by mono aralkyl and manoalkyl esters of meso-2,3 dimercapto succinic acid and by a dithio-carbamate. Pharmacol. Toxicol. 74:76-81.
16. Litchfield, J. T., and Wilcoxon, F. 1949. A simplified method of evaluating dose effect experiments. J. Pharmacol. Exp. Ther. 96:99-113.
17. Llobet, J. M., Domingo, J. L., Gomez, M., Tomas, J. M., and Corbella, J. 1987. Acute toxicity studies of Aluminium compounds: Antidotal efficacy of several chelating agents. Pharmacol. Toxicol. 60:280-283.
18. Nomiyama, K. 1986. The chronic toxicity of cadmium: Influence of environmental and other variables. In Cadmium, ed. E. C. Foulkes, pp. 101-133. Berlin: Springer-Verlag.
19. Pressman, B. C., Harris, E. J., Jaggar, W. S., and Janson, J. H. 1967. Antibiotic mediated transport of alkali metal ions across lipid barriers. Proc. Natl. Acad. Sci. USA 58:1949-1956.
20. Rivera, M., Zheng, W., Aposhian, H. V., and Fernando, Q. 1989. Determination and metabolism of dithiol chelating agents VIII. Metal complexes of meso-dimercaptosuccinic acid. Toxicol. Appl. Pharmacol. 100:96-106.
21. Singh, P. K., Jones, M. M., Jones, S. G., Gale, G. R., Atkin, L. M., Smith, A. B., and Bulman, R. A. 1989. Effect of chelating agent structure on the mobilization of cadmium from intracellular deposits. J. Toxicol. Environ. Health 28:501-518.
22. Srivastava, S., Gupta, S., Behari, J. R., and Srivastava, R. C. 1991a. Mobilization of cadmium by liposome encapsulated meso-2-3-dimercaptosuccinic acid in pre-exposed mice. Toxicol. Lett. 59:125-131.
23. Srivastava, S. K., Srivastava, A., Katiyar, S. S., Jyotsna, Behari J. R., and Srivastava, R. C. 1991b. Alleviation of nickel mediated biochemical alterations by cyclic and linear tetramines. Chemosphere 22:273-278.
24. Zheng, W., Maiorino, R. M., Brendel, K., and Aposhian, H. V. 1990. Determination and metabolism of dithiol chelating agents VII. Biliary excretion of dithiols and their interactions with cadmium and metallothionein. Fundam. Appl. Toxicol. 14:598-607.