Characterization of phloretin-sensitive urea export from the perfused rat liver

Biological Chemistry Hoppe-Seyler

Volumn 377, Issue 1, 1996, Pages 25-37

  Vom Dahl, Stephan ^a   Häussinger, Dieter ^a  

^a Medizinische Einrichtungen der Heinrich HeineUniversität   (Germany)

Author keywords

Perfused rat liver; Phloretin; Urea transport; Water transport

Indexed keywords

ACETOPHENONE DERIVATIVE; BUTYROPHENONE DERIVATIVE; PHENOL DERIVATIVE; PHLORETIN; SODIUM ION; UREA;

ANIMAL TISSUE; ARTICLE; CELL MEMBRANE TRANSPORT; CONTROLLED STUDY; LIVER CELL MEMBRANE; LIVER METABOLISM; LIVER PERFUSION; MALE; NITROGEN METABOLISM; NONHUMAN; OSMOLARITY; PRIORITY JOURNAL; RAT; WATER TRANSPORT;

EID: 0030065845     PISSN: 01773593     EISSN: None     Source Type: Journal    
DOI: 10.1515/bchm3.1996.377.1.25     Document Type: Article

References (37)

1. andersen, O.S., Finkelstein, A., Katz, I., and Cass, A. (1976). Effect of phloretin on the permeability of thin lipid membranes. J. Gen. Physiol. 67,749-771.
2. Brahm, J. (1983). Urea permeability of human red cells. J. Gen. Physiol. 02,1-23.
3. Chamberlin, M.E., and Strange, K. (1989). Anisosmotic cell volume regulation: a comparative view. Am. J. Physiol. 257, C 159-173.
4. Chou, C., and Knepper, M.A. (1989). Inhibition of urea transport in inner medullary collecting ducts by phloretin and urea analogues. Am J. Physiol. 257, F 359-365.
5. Deuticke, B. (1977). Properties and structural basis of simple diffusion pathways in the erythrocyte membrane. Rev. Physiol. Biochem. Pharmacol. 78, 2-97.
6. Deuticke, B., Liitkemeier, P., and Poser, B. (1991). Influence of phloretin and alcohols on barrier defects in the erythrocyte membrane caused by oxidative injury and electroporation. Biochim. Biophys. Acta 7067,111-122.
7. Deuticke, B., Klonk, S., and Haest, C.W.M. (1992). Erythrocyte membrane barrier function: role of bilayer polarity and skeletal proteins. Biochem. Soc. Trans. 20, 769-773.
8. Effros, R.M., Jacobs, E., Hacker, A., Ozker, K., and Murphy, C. (1993). Reversible inhibition of urea exchange in rat hepatocytes. J. Clin. Invest. 91,2822-2828.
9. Gailuci, E., Micelli, S., and Lippe, C. (1971). Non-electrolyte permeability across thin lipid membranes. Arch. Int. Physiol. Biochim. 79,881-887.
10. Goresky, C.A. (1963). A linear method for determining liver sinusoidal and extravascular volumes. Am. J. Physiol. 204, 626640.
11. Grisolia, S., Baguena, R., and Mayor, R, eds. (1976). The Urea Cycle. (New York: J. Wiley and Sons).
12. Gschwendt, M., Horn, F., Kittstein, W., Fürstenberger, G., Rosenfelder, E., and Marks, F. (1984). Calcium and phospholipiddependent protein kinase activity in mouse epidermis cytosol. Stimulation by complete and incomplete tumor promoters and inhibition by various compounds. Biochem. Biophys. Res. Comm. 124,63-68.
13. Gschwendt, M., Kittstein, W., and Marks, F. (1994). Elongation factor-2 kinase: effective inhibition by the novel protein kinase inhibitor rottlerin and relative insensitivity towards staurosporin. FEBS Lett. 338,85-88.
14. Haddad, P., Thalhammer, T., and Graf, J. (1989). Effect of hypertonic stress on liver cell volume, bile flow and volume-regulatory K+ fluxes. Am. J. Physiol. 256, G 563-569.
15. Häussinger, D. (1983). Hepatocyte heterogeneity in glutamine and ammonia metabolism and the role of an intercellular glutamine cycle during ureogenesis in perfused rat liver. Eur. J. Biochem. 733,269-275.
16. Häussinger, D. (1990). Nitrogen metabolism in liver: structural and functional organization and physiological relevance. Biochem. J. 267,281-290.
17. Häussinger, D., Stehle, T., and Lang, F. (1990). Volume regulation in liver: further characterization by inhibitors and ionic substitution. Hepatology 11,243-254.
18. Häussinger, D., Lang, F., and Gerok, W. (1994). Regulation of cell function by the cellular hydration state. Am. J. Physiol. E 343-355.
19. Hallbrucker, C., Vom Dahl, S., Ritter, M., Lang, F., and Häussinger, D. (1994). Effects of urea on Kfluxes and cell volume in perfused rat liver. Pflügers Arch. Physiol. 428,552-560.
20. Hallbrucker, C., Vom Dahl, S., Lang, F., and Häussinger, D. (1991). Control of hepatic proteolysis by amino acids. Eur. J. Biochem. 797,717-724.
21. Hasegawa, H., and Verkman, A.S. (1993). Functional expression of cAMP-dependent and independent urea transporters in Xenopus oocytes. Am. J. Physiol. 265, C 514-520.
22. Knepper, M.A., and Roch-Ramel, F. (1987). Pathways of urea transport in the mammalian kidney. Kidney International 37, 629-633.
23. Knepper, M.A., and Star, R.A. (1990). Vasopressin-regulated urea transporter in renal inner medullary collecting duct. Am. J. Physiol. 259, F 393-F 401.
24. Krebs, H.A., and Henseleit, K. (1932). Untersuchungen über die Harnstoffbildung im Tierkörper. Hoppe-Seyler's Z. Physiol. Chemie 2)0,33-66.
25. Krupka, R.M. (1985). Asymmetrical binding of phloretin to the glucose transport system of human erythrocytes. J. Membr. Biol. 03,71-80.
26. Lang, F., Stehle, T., and Häussinger, D. (1989). Pflügers Arch. Physiol. 473,209-216.
27. Macey, R.l. (1984). Transport of water and urea in red blood cells. Am. J. Physiol. 246, C195-203.
28. Meijer, A.J., Lamers, W.H., and Chamuleau, R.A.F.M. (1990). Nitrogen metabolism and ornithine cycle function. Physiol. Rev. 70,701-748.
29. Menyhart, J. and Grof, J. (1977). Urea as a selective inhibitor of argininosuccinate lyase. Eur. J. Biochem. 77,405-409.
30. Olives, B., Neau, P., Bailly, P., Hediger, MA, Rousselet, G., CarIron, J.P., and Ripoche, P. (1994). Cloning and functional expression of a urea transporter from human bone marrow cells. J. Biol. Chem. 269,31649-31652.
31. Pessin, J.E., and Bell, G.J. (1992). Mammalian facilitativeglucose transporter family: structure and molecular regulation. Ann. Rev. Physiol. 54,911-930.
32. Scharschmidt, B.F., Lake, J.R., Renner, E.L, Licko, V, and van Dyke, R.W. (1986). Fluid phase endocytosis by cultured rat hepatocytes and perfused rat liver: implications for plasma membrane turnover and vesicular trafficking of fluid phase markers. Proc. Natl. Acad. Sei. USA 83,9488-9492.
33. Sies, H. (1978). The use of perfusion of liver and other organs for the study of microsomal electron transport and cytochrome P-450 systems. Methods Enzymol. 52,48-59.
34. Vom Dahl, S., Hallbrucker, C., Lang, F., Gerok, W., and Häussinger, D. (1991). A non-invasive technique for cell volume determination in perfused rat liver. Biol. Chem. Hoppe-Seyier 372, 411-418.
35. Walsh, P.J., Wood, C.M., Perry, S.F., and Thomas, S. (1994). Urea transport by hepatocytes and red blood cells of selected elasmobranch and teleost fishes. J. Exp. Bioi. 193,321-335.
36. Walter, A., and Gutknecht, J. (1986). Permeability of small nonelectrolytes through lipid bilayer membranes. J. Membrane Biol. 90,207-217.
37. You, G., Smith, C.P., Kanai, Y., Lee, W., Stelzner, M., and Hediger, M.A. (1993). Cloning and characterization of the vasopressinregulated urea transporter. Nature 365,844-846.