Role of serotonergic neurons in the maintenance of the 10-Hz rhythm in sympathetic nerve discharge

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 270, Issue 1 39-1, 1996, Pages

  Orer, Hakan S ^b   Clement, Mark E ^b   Barman, Susan M ^b   Zhong, Sheng ^b   Gebber, Gerard L ^b   McCall, Robert B ^a  

^a PFIZER INC   (United States)

^b NONE

Author keywords

5 HT(1A) and 5 HT2 receptors; medullary raphe nuclei; serotonin

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 2,3,3A,4,5,9B HEXAHYDRO 3 PROPYL 1H BENZ[E]INDOLE 9 CARBOXAMIDE; 4 IODO 2,5 DIMETHOXYAMPHETAMINE; METHYSERGIDE; N METHYL DEXTRO ASPARTIC ACID; N TERT BUTYL 3 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL] 2 PHENYLPROPIONAMIDE; SEROTONIN 1A AGONIST; SEROTONIN 1A ANTAGONIST; SEROTONIN 2 AGONIST; SEROTONIN 2 ANTAGONIST; SEROTONIN AGONIST; SEROTONIN ANTAGONIST; SPIPERONE; UNCLASSIFIED DRUG; URETHAN;

ANESTHESIA INDUCTION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CAT; CONTROLLED STUDY; DENERVATION; DOSE RESPONSE; DRUG SELECTIVITY; HISTOLOGY; INTRAVENOUS DRUG ADMINISTRATION; MICROINJECTION; NERVE CONDUCTION; NONHUMAN; PRESSORECEPTOR; PRIORITY JOURNAL; RAPHE NUCLEUS; SEROTONINERGIC NERVE CELL; SEROTONINERGIC TRANSMISSION; SYMPATHETIC NERVE;

EID: 0030065827     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.1996.270.1.r174     Document Type: Article

References (34)

1. Barman, S. M., and G. L. Gebber. Rostral ventrolateral medullary and caudal medullary raphe neurons with activity correlated to the 10-Hz rhythm in sympathetic nerve discharge. J. Neurophysiol. 68: 1535-1547, 1992.
2. Barman, S. M., and G. L. Gebber. Lateral tegmental field neurons play a permissive role in governing the 10-Hz rhythm in sympathetic nerve discharge. Am. J. Physiol. 265 (Regulatory Integrative Camp. Physiol. 34). R1006-R1013, 1993.
3. Barman, S. M., G. L. Gebber, and S. Zhong. The 10-Hz rhythm in sympathetic nerve discharge. Am. J. Physiol. 262 (Regulatory Integrative Comp. Physiol. 31): R1006-R1014, 1992.
4. Barman, S. M., H. S. Orer, and G. L. Gebber. Caudal ventrolateral medullary neurons are elements of the network responsible for 10-Hz rhythm in sympathetic nerve discharge J. Neurophysiol. 72: 106-120, 1994.
5. Barman, S. M., H. S. Orer, and G. L. Gebber. A 10-Hz rhythm reflects the fundamental organization of a brainstem network that specifically governs sympathetic nerve discharge. Brain Res. 671: 345-350, 1995.
6. Berman, A. L. The Brainstem of the Cat. A Cytoarchitectotonic Atlas With Stereotaxic Coordinates. Madison, WI: Univ. of Wisconsin Press, 1968.
7. Brown, C. M., A. C. MacKinnon, J. C. McGrath, M. Spedding, and A. T. Kilpatrick. Heterogeneity of α2-adrenoreceptors in rat cortex but not in human platelets can be defined by 8-OH DPAT, Ru 24969, and methysergide. Br. J. Pharmacol. 99: 481-486, 1990.
8. Clement, M. E., and R. B. McCall. Studies on the site and mechanism of the sympatholytic action of 8-OH DPAT. Brain Res. 525: 232-241, 1990.
9. 2 agonists. Brain Res. 515: 299-302, 1990.
10. Clement, M. E., and R. B. McCall. Evidence that the lateral tegmental field plays an important role in the central sympatho-inhibitory action of 8-OH DPAT. Brain Res. 587: 115-122, 1992.
11. Clement, M. E., and R. B. McCall. Lateral tegmental field involvement in the central sympathoinhibitory action of 8-OH DPAT. Brain Res. 612: 78-84, 1993.
12. 1A receptor antagonist activity of WAY-100135 and spiperone. J. Pharmacol. Exp. Ther. 268: 441-447, 1994.
13. Jacobs, B. L., and E. C. Azmitia. Structure and function of the brain serotonin system Physiol. Rev. 72: 165-229, 1992
14. 1A receptor agonist with good oral availability. J. Med. Chem. 36: 2208-2218, 1993.
15. Loewy, A. D., and S. McKellar. Serotonergic projections form the ventral medulla to the intermediolateral cell column in the rat. Brain Res. 211: 46-152, 1981
16. McCall, R. B. Evidence for a serotonergically mediated sympathoexcitatory response to stimulation of medullary raphe nuclei. Brain Res. 311: 131-139, 1984.
17. McCall, R. B., and M. E. Clement. Identification of serotonergic and sympathetic neurons in medullary raphe nuclei. Brain Res. 477: 172-182, 1989.
18. 2 receptors in the central regulation of the cardiovascular system. Pharmacol. Rev. 46: 231-243, 1994.
19. McCall, R. B., M. E. Clement, and L. T. Harris. Studies on the mechanism of the sympatholytic effect of 8-OH DPAT: lack of correlation between inhibition of serotonin neuronal firing and sympathetic activity. Brain Res. 501: 73-83, 1989.
20. 1A receptor agonists. J. Pharmacol. Exp. Ther. 271: 776-781, 1995.
21. 2 receptor agonists increase spontaneous sympathetic nerve discharge. Eur. J. Pharmacol. 151: 113-116, 1988.
22. McCall, R. B., and S. J. Humphrey. Involvement of serotonin in the central regulation of blood pressure: evidence for a facilitating effect on sympathetic nerve activity. J. Pharmacol. Exp. Ther. 222: 94-102, 1982
23. 2 receptor agonists and antagonists on blood pressure, heart rate and sympathetic nerve activity. J. Pharmacol. Exp. Ther. 242: 1152-1159, 1987.
24. Nosjean, A., and P. G. Guyenet. Role of the ventrolateral medulla in the sympatholytic effect of 8-OHDPAT in rats. Am. J. Physiol. 260 (Regulatory Integrative Comp. Physiol. 29): R600-R609, 1991.
25. Orer, H. S., S. M. Barman, S. Zhong, and G. L. Gebber. A modulatory role of central cholinergic transmission in control of the 10-Hz rhythm in sympathetic nerve discharge. Brain Res. 661: 283-288, 1994.
26. Orer, H. S., S. Zhong, S. M. Barman, and G. L. Gebber. Central catecholaminergic neurons are involved in expression of the 10-Hz rhythm in sympathetic nerve discharge. Am. J. Physiol. (Regulatory Integrative. Comp. Physiol). In press.
27. Ramage, A. G., M. E. Clement, and R. B. McCall. 8-OH DPAT-induced inhibition of renal sympathetic nerve activity and serotonin neuronal firing. Eur. J. Pharmacol. 219: 165-167, 1992.
28. Steriade, M., and R. R. Llinas. The functional states of the thalamus and the associated neuronal interplay. Physiol. Rev. 68: 649-742, 1988.
29. 1A binding sites in the midline raphe and parapyramidal region of the ventral medulla oblongata of the rat. Neurosci. Lett. 108: 249-254, 1990.
30. Wang, W. H., and T. A. Lovick. Inhibitory serotonergic effects on rostral ventrolateral medullary neurons. Pfluegers Arch. 422: 93-97, 1992.
31. Zhong, S., S. M. Barman, and G. L. Gebber. Effects of brain stem lesions on 10-Hz and 2- to 6-Hz rhythms in sympathetic nerve discharge. Am. J. Physiol. 262 (Regulatory Integrative Comp. Physiol. 31): R1015-R1024, 1992.
32. Zhong, S., Z.-S. Huang, G. L. Gebber, and S. M. Barman. The 10-Hz sympathetic rhythm is dependent on raphe and rostral ventrolateral medullary neurons. Am. J. Physiol. 264 (Regulatory Integrative Comp. Physiol. 33): R857-R866, 1993.
33. Zhong, S., Z.-S. Huang, G. L. Gebber, and S. M. Barman. Role of the brain stem in generating the 2- to 6-Hz oscillation in sympathetic rhythm discharge. Am. J. Physiol. 265 (Regulatory Integrative Comp. Physiol. 34): R1026-R1035, 1993.
34. Zifa, E., and G. Fillion 5-Hydroxytryptamine receptors. Pharmacol. Rev. 44: 401-458, 1992.