Synthesis of non-steroidal antiinflammatory drug analogues for selective studies on the COX-II enzyme

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 38, Issue 1, 1996, Pages 13-18

  Fleming, Steven A ^a   Ridges, Michael D ^a   Jensen, Anton W ^a  

^a Brigham Young University   (United States)

Author keywords

azido diclofenac; COX II; photoaffinity labeling

Indexed keywords

ANTI-INFLAMMATORY DRUGS; AZIDO DICLOFENAC; BINDING ABILITIES; COX-II; DICLOFENAC; ISOTOPE LABELING; PHENYLACETIC ACID; PHOTOAFFINITY LABELING;

ENZYMES;

AZIDODICLOFENAC; DICLOFENAC; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN SYNTHASE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; ISOTOPE LABELING;

EID: 0030065242     PISSN: 03624803     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1344(199601)38:1<13::AID-JLCR807>3.0.CO;2-D     Document Type: Article

References (13)

1. Vane, J. R. - Nature 231: 232 (1971).
2. Willis, A. L. - Parmacol. Res. Commun. 2; 297 (1970).
3. Xie, W.; Robertson, D.L.; Simmons, D. L. - Drug Development Research 25: 249 (1992).
4. Merck Index (9th Ed.), Merck & Co., Rahway, New Jersey, 1976.
5. Bennet, A. - The Prostaglandin System, Berti, F. and Velo, G. P. eds, Plenum Press, New York, 417, 1981.
6. Marnett, L. J. - Cancer Res. 52: 5575 (1992).
7. Eyett, G. A. Ph.D. Thesis, Brigham Young Univeristy, 1993.
8. Xie, W.; Chipman, J.; Robertson, D. L.; Erikson, R. L.; Simmons, D. L. - Proc. Natl. Acad. Sci. USA 88: 2692 (1991).
9. Bayley, H. - Photogenerated Reagents in Biochemistry and Molecular Biology, Elsevier, Amsterdam, 1983.
10. Fleming, S. A.; Reber, J. Abstract CHRP # 0254, - 209th American Chemical Society National Meeting, Anaheim, CA, 1995.
11. Tapia, R.; Torres, G.; Valderrama, J. A. - Syn. Commun. 16: 681 (1986).
12. Skiles, J. W.; Cava, M. P. - J. Org. Chem. 44: 409 (1979).
13. Castell, J. V.; Martinez, L. A.; Miranda, M. A.; Tárrega, P. - Journal of Labelled Compounds & Radiopharmaceuticals 34: 93 (1993).