Induction of long-term graft tolerance and donor/recipient chimerism

Journal of Surgical Research

Volumn 60, Issue 1, 1996, Pages 181-185

  Fisher, Robert A ^a   Cohen, Dennis S ^a   Ben Ezra, Jonathan M ^a   Sallade, Ross E ^a   Tawes, John W ^a   Tarry, Wallace C ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN A; IMMUNOSUPPRESSIVE AGENT; MONOCLONAL ANTIBODY; RAPAMYCIN;

ALLOGRAFT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD TRANSFUSION; CHIMERA; CONTROLLED STUDY; DRUG EFFECT; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE TREATMENT; INTRAPERITONEAL DRUG ADMINISTRATION; LYMPH NODE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SPLEEN; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0030065234     PISSN: 00224804     EISSN: None     Source Type: Journal    
DOI: 10.1006/jsre.1996.0029     Document Type: Article

References (20)

1. UNOS. 1993 Annual Report of the U.S. Scientific Registry of Transplant Recipients and the Organ Procurement and Transplantation Network. Transplant Data 1988-1991.
2. Terasaki, P. I. The beneficial transfusion effect on kidney graft survival attributed to clonal deletion. Transplantation 37: 119, 1984.
3. Marquet, R. L., and Heystek, G. A. Induction of suppressor cells by donor-specific blood transfusions and heart transplantation in rats. Transplantation 31: 272, 1981.
4. Macleod, A. M., Mason, R. J., Stewart, K. N., et al. Association of Fc receptor blocking antibodies and human renal transplant survival. Transplantation 34: 273, 1982.
5. Downey, W. E., Baldwin, W. M., and Sanfilippo, F. Association of donor-specific blood transfusion enhancement of rat renal allografts with accelerated development of anti-idiotypic antibodies and reduced alloantibody responses. Transplantation 49: 160, 1990.
6. Hess, A. D., Esa, A. H., and Colombani, P. M. Mechanisms of action of cyclosporine: Effect on cells of the immune system and on subcellular events in T cell activation. Transplant. Proc. 20: 29, 1988.
7. Yoshimura, N., Matsui, S., Hamashima, T., et al. Effect of a new immunosuppressive agent, FK506, on human lymphocyte responses in vitro: Inhibition of expression of alloantigen-activated suppressor cells, as well as induction of alloreactivity. Transplantation 47: 351, 1989.
8. Yoshimura, N., Matsui, S., Hamashima, T., et al. Effect of a new immunosuppressive agent, FK506, on human lymphocyte responses in vitro: Inhibition of the production of IL-2 and gamma-interferon, but not B cell-stimulating factor 2. Transplantation 47: 356, 1989.
9. Kahan, B. D., Chang, J. Y., and Sehgal, S. N. Preclinical evaluation of a new potent immunosuppressive agent rapamycin. Transplantation 52: 185, 1991.
10. Starzl, T. E., Demetris, A. J., Murase, N., et al. Cell migration, chimerism and graft acceptance. Lancet 339: 1579, 1992.
11. Starzl, T. E., Demetris, A. J., Trucco, M., et al. Chimerism and donor-specific nonreactivity 27 to 29 years after kidney allo-transplantation. Transplantation 55: 1272, 1993.
12. Starzl, T. E., Fung, J., Tzakis, A., et al. Baboon-to-human liver transplantation. Lancet 341: 65, 1993.
13. Austyn, J. M. Lymphoid dendritic cells. Immunology 62: 161, 1987.
14. Ono, K., and Lindsey, E. Improved technique of heart transplantation in rats. J. Thoracic Cardiovasc. Surg. 57: 225, 1969.
15. Fisher, R. A., Cohen, D. S., Tarry, W. C., et al. A comparison of the immunosuppressive activity and systemic toxicity of cyclosporine A, cyclosporine G, rapamycin and multiple donor-specific blood transfusions. Submitted for publication.
16. Kimball, P. M., Kerman, R. H., and Kahan, B. D. Production of synergistic but non-identical mechanisms of immunosuppression by rapamycin and cyclosporine. Transplantation 51: 486, 1991.
17. Davies, C. B., Madden, R. L., Alexander, J. W., et al. Effect of a short course of rapamycin, cyclosporin A and donor-specific transfusion on rat cardiac allograft survival. Transplantation 55: 1107, 1993.
18. Kupiec-Weglinski, J. W., Filho, M. A., Strom, T. B., et al. Sparing of suppressor cells: A critical action of cyclosporine. Transplantation 38: 97, 1984.
19. Starzl, T. E., Demetris, A. J., Trucco, M., et al. Cell migration and chimerism after whole-organ transplantation: The basis of graft acceptance. Hepatology 17: 1127, 1993.
20. Starzl, T. E. Cell migration and chimerism - A unifying concept in transplantation with particular reference to HLA matching and tolerance induction. Transplant. Proc. 25: 8, 1993.