Interferon treatment for chronic hepatitis C infection in hemophiliacs - Influence of virus load, genotype, and liver pathology on response

Blood

Volumn 87, Issue 5, 1996, Pages 1704-1709

  Hanley, John P ^a   Jarvis, Lisa M ^b   Andrews, Janet ^b   Dennis, Rosemary ^b   Hayes, Peter C ^b   Piris, Juan ^b   Lee, Robert ^b   Simmonds, Peter ^b   Ludlam, Christopher A ^b  

^a ROYAL INFIRMARY OF EDINBURGH   (United Kingdom)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA2A INTERFERON; VIRUS RNA;

ADOLESCENT; ADULT; AGED; ARTICLE; CHRONIC HEPATITIS; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; DRUG RESPONSE; FEMALE; GENOTYPE; HEMOPHILIA; HEPATITIS C; HUMAN; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SUBCUTANEOUS DRUG ADMINISTRATION; VIRUS CONCENTRATION;

EID: 0030064877     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v87.5.1704.1704     Document Type: Article

References (26)

1. Tedder RS, Briggs M, Ring C, Tuke PW, Jones P, Savidge GF, Rodgers B, Garson JA: Hepatitis C antibody profile and viraemia prevalence in adults with severe haemophilia. Br J Haematol 79:512, 1991
2. Watson HG, Ludlam CA, Rebus S, Zhang LQ, Peutherer JF, Simmonds P: Use of several second generation serological assays to determine the true prevalence of hepatitis C virus infection in haemophiliacs treated with non-virus inactivated factor VIII and IX concentrates, Br J Haematol 80:514, 1992
3. Hay CRM, Preston FE, Triger DR, Underwood JCE: Progressive liver disease in haemophilia: An understated problem. Lancet 1:1495, 1985
4. Preston FE, Dusheiko G, Giangrande PLF, Lee CA, Ludlam CA, Darby S: Hepatocellular carcinoma in UK haemophiliacs. Br J Haematol S1:9, 1995 (abstr)
5. Makris M, Preston FE, Triger DR, Underwood JCE, Westlake L, Adelman MI: A randomized controlled trial of recombinant interferon-α in chronic hepatitis C in haemophiliacs. Blood 78:1672, 1991
6. Bresters D, Mauser-Bunschoten EP, Cuypers HTM, Lelie PN, Han JH, Jansen PLM, Houghton M, Reesink HW: Disappearance of hepatitis C virus RNA in plasma during interferon alpha 2B treatment in haemophilia patients. Scand J Gastroenterol 27:166, 1992
7. Peerlinck K, Willems M, Sheng L, Nevens F, Fevery J, Yap SH, Vermylen J: Rapid clearance of hepatitis C virus RNA in peripheral blood mononuclear cells of patients with clotting disorders and chronic hepatitis C treated with alpha-2b interferon is not a predictor for sustained response to treatment. Br J Haematol 86:816, 1994
8. Mauser Bunschoten EP, Bresters D, Reesink HW, Roosendaal G, Chamuleau RAFM, Hann E, Jansen PLM, Van Den Berg HM: Effect and side-effects of alpha interferon treatment in haemophilia patients with chronic hepatitis C. Haemophilia 1:45, 1995
9. Telfer P, Devereux H, Colvin B, Hayden S, Dusheiko G, Lee C: Alpha interferon for hepatitis C virus infection in haemophilic patients. Haemophilia 1:54, 1995
10. Jalan R, Hayes PC: Laparoscopy in the diagnosis of chronic liver disease. Br J Hosp Med 53:81, 1995
11. Jalan R, Harrison DJ, Dillon JF, Elton RA, Finlayson NDC, Hayes PC: Laparoscopy and histology in the diagnosis of chronic liver disease. Q J Med 88:559, 1995
12. Jarvis LM, Watson HG, McOmish F, Peutherer JF, Ludlam CA, Simmonds P: Frequent reinfection and reactivation of hepatitis C virus genotypes in multitransfused haemophiliacs. J Infect Dis 170-1018, 1994
13. Chan SW, McOmish F, Holmes EC, Dow B, Peutherer JF, Follett E, Yap PL, Simmonds P: Analysis of a new hepatitis C virus type and its phylogenetic relationship to existing variants. J Gen Virol 73.1131, 1992
14. McOmish F, Yap PL, Dow BC, Follett EAC, Seed C, Keller AJ, Cobain TJ, Krusius T, Kolho E, Naukkarinen R: Geographical distribution of hepatitis C virus genotypes in blood donors - An international collaborative survey. J Clin Microbiol 32:84, 1994
15. Davidson F, Simmonds P, Ferguson JC, Jarvis LM, Dow BC, Follett EAC, Seed CRG, Krusius T, Lin C, Medgyesi GA, Kiyokawa H, Olim G, Duraisamy G, Cuypers T, Saeed AA, Ten D, Conradie J, Kew MC, Nuchaprayoon C, Ndimbie OK, Yap PL: Survey of major genotypes and subtypes of hepatitis C virus using restriction fragment length polymorphism of sequences amplified from the 5′ non-coding region. J Gen Virol 76.1197, 1995
16. Simmonds P, Balfe P, Peutherer JF, Ludlam CA, Bishop JO, Brown AJ: Human immunodeficiency virus-infected individuals contain provirus in small numbers of peripheral blood mononuclear cells and at low copy numbers. J Virol 64:864, 1990
17. Simmonds P, Zhang LQ, Watson HG, Rebus S, Ferguson ED, Balfe P, Leadbetter GH, Yap PL, Peutherer JF, Ludlam CA: Hepatitis C quantification and sequencing in blood products, haemophiliacs and drug users. Lancet 336:1469, 1990
18. Tine F, Magrin S, Craxi A, Pagliaro L Interferon for non-A, non-B chronic hepatitis: A meta-analysis of randomised clinical trials. J Hepatol 13:192, 1991
19. Davis GL, Balart LA, Schiff ER, Lindsay K, Bodenheimer HC, Perrillo RP, Carey W, Jacobson IM, Payne J, Dienstag JL, VanThiel DH, Tamburro C, Lefkowitch J, Albrecht J, Meschievitz C, Ortego TJ, Gibas A, Hepatitis Interventional Therapy Group: Treatment of chronic hepatitis C with recombinant interferon alpha. N Engl J Med 321:1501, 1989
20. Marcellin P, Boyer N, Giostra C, Courouce AM, Degos F, Coppere H, Cales P, Couzigou P, Benhamou JP: Recombinant human α-interferon in patients with chronic non-A, non-B hepatitis: A multicenter randomized controlled trial from France. Hepatology 13:393, 1991
21. Shindo M, DiBisceglie AM, Cheung L, Shih W-K, Cristiano K, Feinstone SM, Hoofnagle JH: Decrease in serum hepatitis C viral RNA during alpha-interferon therapy for chronic hepatitis C. Ann Intern Med 115:700, 1991
22. Bresters D, Cuypers HTM, Reesink HW, Mauser-Bunschoten EP, van den Berg HM, Schaasberg WP, Wilber JC, Urdea MS, Neuwald P, Lelie PN: Comparison of quantitative cDNA-PCR with the branched DNA hybridization assay for monitoring plasma hepatitis C virus RNA levels in haemophilia patients participating in a controlled interferon trial. J Med Virol 43:262, 1994
23. Lau JYN, Mizokami M, Ohno T, Diamond DA, Kniffen J, Davis GL: Discrepancy between biochemical and virological responses to interferon-alpha in chronic hepatitis C. Lancet 342:1208, 1993
24. 2 neutralizing antibodies in hepatitis patients. J Interferon Res 14:211, 1994
25. Devereux H, Telfer P, Dusheiko G, Lee C: Hepatitis C genotypes in haemophilic patients treated with alpha-interferon. J Med Virol 45:284, 1995
26. Davis GL: Prediction of response to interferon treatment of chronic hepatitis C. J Hepatol 21:1, 1994