The presence of DNA breaks and the formation of chromatid aberrations after incorporation of 125IdUrd may be necessary but are not sufficient to block cell cycle progression in G2 phase

Radiation Research

Volumn 145, Issue 1, 1996, Pages 17-23

  Schneiderman, Martin H ^a   Schneiderman, G Sue ^a   Mühlmann Díaz, María C ^b   Bedford, Joel S ^b  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b Immunology and Pathology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRICETINAE; CRICETULUS GRISEUS; ANIMALIA;

DEOXYURIDINE; IODINE 125;

ANIMAL CELL; ARTICLE; CELL CYCLE G2 PHASE; CHO CELL; CHROMATID ABERRATION; CHROMOSOME ANALYSIS; DNA DAMAGE; DNA DETERMINATION; DNA STRAND BREAKAGE; NONHUMAN; PRIORITY JOURNAL;

NON-PROGRAMMATIC;

ANIMALS; CELL CYCLE; CHO CELLS; CHROMATIDS; CHROMOSOME ABERRATIONS; CHROMOSOME DELETION; CRICETINAE; DNA DAMAGE; G2 PHASE; GAMMA RAYS; IDOXURIDINE; IODINE RADIOISOTOPES; ISOCHROMOSOMES; KINETICS; MITOSIS; RADIATION TOLERANCE; TIME FACTORS;

EID: 0030064846     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.2307/3579190     Document Type: Article

References (31)

1. R. A. Walters and D. F. Petersen. Radiosensitivity of mammalian cells. I. Timing and dose dependence of radiation-induced division delay. Biophys. J. 8, 1475-1486 (1968).
2. R. L. Warters and K. G. Hofer. Radionuclide toxicity in cultured mammalian cells. Elucidation of the primary site for radiationinduced division delay. Radiat. Res. 69, 348-358 (1977).
3. 125I-UdR induced division delay. Biophys. J. 17. 199-202 (1977).
4. T. Terasima and L. J. Tolmach, Variations in several responses of HeLa cells to X-irradiation during the division cycle. Biophys. J. 3, 11-33 (1963).
5. 2. Nature 254, 245-247 (1975).
6. 2 arrest in Chinese hamster ovary cells. Cancer Res. 50, 3761-3766 (1990).
7. M. H. Schneiderman, W. C. Dewey, D. B. Leeper and H. Nagasawa, Use of the mitotic selection procedure for cell cycle analysis: Comparison between the X-ray and G, markers. Exp. Cell Res. 74, 430-438 (1972).
8. K. G. Hofer, Radiation biology and potential therapeutic applications of radionuclides. Bull. Cancer (Paris) 67, 343-353 (1980).
9. K. G. Hofer, G. Keough and J. M. Smith. Biological toxicity of Auger emitters: molecular fragmentation versus electron irradiation. Curr. Top. Radiat. Res. Q. 12, 335-354 (1977).
10. 125I decays. Radiat. Res. 107, 163-171 (1986).
11. R. F. Martin and W. A. Haseltine, Range of radiochemical damage to DNA with decay of iodine-125. Science 213, 896-898 (1981).
12. H. G. Paretzke, Advances in energy deposition theory. In Advances in Radiation Protection and Dosimetry in Medicine (R. H. Thomas and V. Perez-Mendez, Eds.), pp. 51-73, Plenum Press, New York, 1980.
13. J. L. Humm and D. E. Charlton, A new calculational method to assess the therapeutic potential of Auger electron emission. Im. J Radiat. Oncol. Biol. Phys 17, 351-360 (1989).
14. M. N. Cornforth and J. S. Bedford, Ionizing radiation damage and its early development in chromosomes. In Advances in Radiation Biology, Vol. 17 (J. T. Lett and W. K. Sinclair, Eds.), pp. 423-496. Academic Press. New York. 1993.
15. J. Baranowska-Kortylewicz, L. D. Helseth, J. LaI, M. H. Schneiderman, G. S. Schneiderman and G. V. Dalrymple, Radiolabeling kit/generator for 5-radiohalogenated uridines. J. Lab. Comp. Radiopharm. 34, 513-521 (1993).
16. M. H. Schneiderman. A rapid membrane filter technique for preparing tissue culture cells for scoring mitotic or labeling indices. Stain Technol. 56, 45-47 (1981).
17. M. H. Schneiderman and G. S. Schneiderman, Radio-iododeoxyuridine in cancer therapy: an in vitro approach to developing in vivo strategies. J. Nucl. Med., in press.
18. 123IUdR-release assay for measuring the kinetics of cell death. Int. J. Radiat. Biol. 59, 397-408 (1991).
19. 1-phase CHO cells. Int. I. Radiat. Biol. 52, 705-722 (1987).
20. 125I in cultured human kidney cells and their repair. In Sixth Symposium on Microdosimetry (J. Booz and H. G. Ebert, Eds.), pp. 111-120. Harwood, London, 1978.
21. 123I incorporated into DNA of mammalian cells. Radiat. Environ. Biophys. 18, 239-248 (1980).
22. 125I incorporated into mammalian DNA. Proc. Natl. Acad. Sci. USA 71, 4836-4838 (1974).
23. J. B. Mitchell, J. S. Bedford and S. M. Bailey, Dose-rate effects in mammalian cells in culture. III. Comparison of cell killing and cell proliferation during continuous irradiation for six different cell lines. Radiai. Res. 79, 537-551 (1979).
24. M. A. Stackhouse and J. S. Bedford, An ionizing radiation-sensitive mutant of CHO cells: irs-20. III. Chromosome aberrations. DNA breaks and mitotic delay. Int. J. Radiat. Biol. 65, 571-582 (1994).
25. E. Stubblefield, Analysis of the replication pattern of Chinese hamster chromosomes using 5-bromodeoxyuridine suppression of Hoechst fluorescences. Chromosoma 53, 209-221 (1975).
26. A. Cole, R. Chen and I. Kristal, Division delay in CHO cell induced by partly penetrating alpha particles. Radiat. Res. 70, 640 (1977). [Abstract]
27. M. H. Schneiderman and K. G. Hofer, The target for radiationinduced division delay. Radiat. Res. 84, 462-476 (1980).
28. M. H. Schneiderman, K. G. Hofer and G. S. Schneiderman, Association between the division delay target and DNA late in the cell cycle. Radiat. Res. 122, 337-340 (1990).
29. M. A. Stackhouse and J. S. Bedford, An ionizing radiation-sensitive mutant of CHO cells: irs-20. I. Isolation and initial characterization. Radiat. Res. 136, 241-249 (1993).
30. M. A. Stackhouse and J. S. Bedford, An ionizing radiation-sensitive mutant of CHO cells: irs-20. II. Dose-rate effects and cellular recovery processes. Radiat. Res. 136, 250-254 (1993).
31. N. Johnson and S. Kotz, Discrete Distributions. Wiley, New York, 1969.