A viral movement protein as a nuclear shuttle: The geminivirus BR1 movement protein contains domains essential for interaction with BL1 and nuclear localization

Plant Physiology

Volumn 110, Issue 1, 1996, Pages 23-33

  Sanderfoot, Anton A ^a   Ingham, David J ^a   Lazarowitz, Sondra G ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; GEMINIVIRIDAE; MYTHIMNA UNIPUNCTA; NICOTIANA TABACUM; TABACUM;

EID: 0030064325     PISSN: 00320889     EISSN: None     Source Type: Journal    
DOI: 10.1104/pp.110.1.23     Document Type: Article

References (47)

1. Abel S, Theologis A (1995) A polymorphic bipartite motif signals nuclear targeting of early auxin-inducible proteins related to PS-IAA4 from pea (Pisum sativum). Plant J 8: 101-110
2. Bataille N, Helser T, Fried HM (1990) Cytoplasmic transport of ribosomal subunits microinjected into the Xenopus laevis oocyte nucleus: a generalized, facilitated process. J Cell Biol 111: 1571-1582
3. Boehm U, Heinlein M, Behrens U, Kunze R (1995) One of three nuclear localization signals of maize Activator (Ac) transposase overlaps the DNA-binding domain. Plant J 7: 441-451
4. Borer RA, Lehner CF, Eppenberger HM, Nigg EA (1989) Major nucleolar proteins shuttle between the nucleus and cytoplasm. Cell 56: 379-390
5. Brough CL, Hayes RJ, Morgan AJ, Coutts RH, Buck KW (1988) Effects of mutagenesis in vitro on the ability of cloned tomato golden mosaic virus DNA to infect Nicotiana benthamiana plants. J Gen Virol 69: 503-514
6. Carrington JC, Freed DD, Leinicke AJ (1991) Bipartite signal sequence mediates nuclear translocation of the plant potyviral NIa protein. Plant Cell 3: 953-962
7. Carswell S, Alwine JC (1986) Simian virus 40 agnoprotein facilitates perinuclear-nuclear localization of VP, the major capsid protein. J Virol 60: 1055-1061
8. Citovsky V, McLean BG, Zupan JR, Zambryski P (1993) Phosphorylation of tobacco mosaic virus cell-to-cell movement protein by a developmentally regulated plant cell wall-associated protein kinase. Genes Dev 7: 904-910
9. Citovsky V, Zupan J, Warnick D, Zambryski P (1992) Nuclear localization of the VirE2 protein in plants cells. Science 256: 1802-1805
10. Cunningham BC, Wells JA (1989) High-resolution epitope mapping of hGH-receptor interactions by alanine-scanning mutagenesis. Science 244: 1081-1085
11. Dehesh K, Smith LG, Tepperman JM, Quail P (1995) Twin autonomous bipartite nuclear localization signals direct nuclear import of GT-2. Plant J 8: 25-36
12. Etessami P, Callis R, Ellwood S, Stanley J (1988) Delimitation of the essential genes of the cassava latent virus DNA 2. Nucleic Acids Res 16: 4811-4829
13. Faure R, Posner BI (1993) Differential intracellular compartmentalization of phosphotyrosine phosphatases in a glial cell line: TC-PTP versus FTP-1B. Glia 9: 311-314
14. Fischer U, Huber J, Boelens WC, Mattaj IW, Lührmann R (1995) The HIV-1 rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs. Cell 82: 476-483
15. Gorlich D, Prehn R, Laskey A, Hartmann E (1994) Isolation of a protein that is essential for the first step of nuclear proteins import. Cell 79: 767-778
16. Guichon-Mantel A, Delabre K, Lescop P, Milgrom E (1994) Nuclear localization signals also mediate the outward movement of proteins from the nucleus. Proc Natl Acad Sci USA 91: 7179-7183
17. Guichon-Mantel A, Lescop P, Christin-Maitre S, Loosefelt H, Perrot-Applanat M, Milgrom E (1991) Nucleocytoplasmic shuttling of the progesterone receptor. EMBO J 10: 3851-3859
18. Hicks GR, Smith HMS, Shieh M, Raikhel NV (1995) Three classes of nuclear import signals bind to plant nuclei. Plant Physiol 107: 1055-1058
19. Howard EA, Zupan JR, Citovsky V, Zambryski PC (1992) The VirD2 protein of A. tumefaciens contains a C-terminal bipartite nuclear localization signal: implications for nuclear uptake of DNA in plant cells. Cell 68: 109-118
20. Ingham DJ, Pascal E, Lazarowitz SG (1995) Both geminivirus movement proteins define viral host range, but only BL1 determines viral pathogenicity. Virology 207: 191-204
21. Jefferson RA, Kavanaugh TA, Bevan MW (1987) GUS fusions: β-glucuronidase as a sensitive and versatile gene fusion marker in higher plants. EMBO J 6: 3901-3907
22. Kalderon D, Roberts BL, Richardson WD, Smith AE (1984) A short amino acid sequence able to specify nuclear localization. Cell 39: 499-509
23. Kambach C, Mattaj IW (1992) Intracellular distribution of the U1A protein depends on active transport and nuclear binding to U1 snRNA. J Cell Biol 118: 11-21
24. Laskey RA, Dingwall C (1993) Nuclear shuttling: the default pathway for nuclear proteins? Cell 74: 585-586
25. Lazarowitz SG, Lazdins IB (1991) Infectivity and complete nucleotide sequence of the cloned genomic components of a bipartite squash leaf curl geminivirus with a broad host range phenotype. Virology 180: 58-69
26. Mandel RB, Feldherr CM (1990) Identification of two HSP70-related Xenopus oocyte proteins that are capable of recycling across the nuclear envelope. J Cell Biol 111: 1775-1783
27. Martin A, Helenius A (1991a) Transport of incoming influenza virus nucleocapsids into the nucleus. J Virol 265: 232-244
28. Martin K, Helenius A (1991b) Nuclear transport of influenza virus ribonucleoproteins: the viral matrix protein (M1) promotes export and inhibits import. Cell 67: 117-130
29. Meier UT, Blobel G (1992) Nopp140 shuttles of tracks between nucleolus and cytoplasm. Cell 73: 127-138
30. Mukaigawa J, Nayak DP (1991) Two signals mediate nuclear localization of influenza virus (A/WSN/33) polymerase basic protein 2. J Virol 65: 245-253
31. Newmeyer DD, Forbes DJ (1988) Nuclear import can be divided into distinct steps in vitro: nuclear pore binding and translocation. Cell 52: 641-653
32. Pascal E, Goodlove PE, Wu LC, Lazarowitz SG (1993) Transgenic tobacco plants expressing the geminivirus BL1 protein exhibit symptoms of viral disease. Plant Cell 5: 795-807
33. Pascal E, Sanderfoot AA, Ward BM, Medville R, Turgeon R, Lazarowitz SG (1994) The geminivirus BR1 movement protein binds single-stranded DNA and localizes to the cell nucleus. Plant Cell 6: 995-1006
34. Pinol-Roma S, Dreyfuss G (1992) Shuttling of pre-mRNA binding proteins between nucleus and cytoplasm. Nature 355: 730-732
35. Raikhel N (1992) Nuclear targeting in plants. Plant Physiol 100: 1627-1632
36. Restrepo MA, Freed DD, Carrington JC (1990) Nuclear transport of plant potyviral proteins. Plant Cell 2: 987-998
37. Robbins J, Dilworth SM, Laskey RA, Digwall C (1991) Two interdependent basic domains in nucleoplasmin nuclear targeting sequence: identification of a class of bipartite nuclear targeting sequence. Cell 64: 615-623
38. Sanderfoot AA, Lazarowitz SG (1995) Cooperation in viral movement: the geminivirus BL1 movement protein interacts with BR1 and redirects it from the nucleus to the cell periphery. Plant Cell 7: 1185-1194
39. Sanger F, Nicklen S, Coulson AR (1977) DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci USA 74: 5463-5467
40. Schmidt-Zachmann MS, Dargemont C, Kuhn LC, Nigg EA (1993) Nuclear export of proteins: the role of nuclear retention. Cell 74: 493-504
41. Shieh M, Wessler SR, Raikhel NV (1993) Nuclear targeting of the maize R protein requires two localization sequences. Plant Physiol 101: 353-361
42. Silver PA (1991) How proteins enter the nucleus. Cell 64: 489-497
43. Studinger J, Zhou J, Burgess R, Elledge SJ, Olson EW (1995) PICK1: a perinuclear binding protein and substrate for protein kinase C isolated by the yeast two-hybrid system. J Cell Biol 128: 263-271
44. Varagona MJ, Schmidt RJ, Raikhel NV (1992) Nuclear localization signal(s) required for nuclear targeting of the maize regulatory protein Opaque-2. Plant Cell 4: 1213-1227
45. Wen W, Meinkoth JL, Tsien RY, Taylor SS (1995) Identification of a signal for rapid exports of proteins from the nucleus. Cell 82: 463-473
46. Whiteside ST, Goodbourn S (1993) Signal transduction and nuclear targeting: regulation of transcription factor activity by subcellular localization. J Cell Sci 104: 949-955
47. Worrad DM, Caradonna S (1993) The herpes simplex virus type 2 UL3 open reading frame encodes a nuclear localizing phosphoprotein. Virology 195: 364-376