Polyalkylation of primary polyols by 1,4-addition to tert-butyl acrylate and acrylonitrile

Tetrahedron Letters

Volumn 37, Issue 8, 1996, Pages 1237-1240

  Dupraz, Agnès ^a   Guy, Philippe ^b   Dupuy, Claude ^a  

^a CNRS   (France)

^b CEA GRENOBLE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID DERIVATIVE; LANTHANIDE; POLYOL; SAMARIUM;

ALKYLATION; ARTICLE; CHELATION; DRUG SYNTHESIS; INFRARED SPECTROPHOTOMETRY; MASS SPECTROMETRY; REACTION ANALYSIS;

EID: 0030063878     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/0040-4039(96)00008-1     Document Type: Article

References (17)

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4. a) Bruson, H.A. U.S. Patent 2,401,607 ; Chem. Abstr. 1946, 40, 5450.
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10. Control of the temperature (10 to 20 °C) is necessary to avoid side reactions such as 1,4-addition of hydroxide.
11. 3 (68%).
12. 13C NMR δ 170.9, 80.2, 69.6, 67.0, 45.2, 36.3, 28.0.
13. a) Subramanian, R. ; Colony, J. ; Shaban, S. ; Sidrak, H. ; Haspel, M. V. ; Pomato, N. ; Hanna, M. G. and McCabe, R. P. Bioconjugate Chem. 1992, 3, 248-255.
14. 6)] by Dr. Alain Faivre-Chauvet (INSERM U.211 - University of Nantes) who is gratefully thanked.
15. 2) and fully characterized by spectroscopic and analytical data.
16. Nakamoto, K. Infrared and Raman Spectra of Inorganic and Coordination Compounds, J. Wiley, New-York, 1978.
17. ESI-MS was performed using a SCIEX API III+ quadrupole mass spectrometer (Perkin-Elmer Sciex Instruments, Thornhill, Canada) equiped with a nebulizer-assisted electrospray (ionspray) source. Calibration was performed using poly(propylene glycol) ions. The samples were solubilized in water then infused using a syringe pump (Harvard 22, South Natic, USA) at a flow rate of 5μl/min. The mass spectrometer was scanned from m/z = 200 to 1500 at 0.5 Da steps and 2 ms per step. Mass spectra were analyzed using a Quadra 950 data system (Apple Computer Inc., Cuppertino, USA).