Structural biology of glycoprotein IIb-IIIa

Trends in Cardiovascular Medicine

Volumn 6, Issue 1, 1996, Pages 31-36

  Bennett, Joel S ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FIBRINOGEN; GLYCOPROTEIN IIB; GLYCOPROTEIN IIIA; VON WILLEBRAND FACTOR;

BINDING SITE; CELL SURFACE; CONFORMATIONAL TRANSITION; CYTOSKELETON; ENDOPLASMIC RETICULUM; GOLGI COMPLEX; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN TRANSPORT; SHORT SURVEY; THROMBOCYTE AGGREGATION;

EID: 0030063593     PISSN: 10501738     EISSN: None     Source Type: Journal    
DOI: 10.1016/1050-1738(95)00126-3     Document Type: Short Survey

References (40)

1. Bajt M, Loftus J: 1994. Mutation of a ligand binding domain of beta 3 integrin: integral role of oxygenated residues in alpha IIb beta 3 (GPIIb-IIIa) receptor function. J Biol Chem 269:20,913-20,919.
2. Bennett JS, Shattil SJ, Power JW, Gartner TK: 1988. Interaction of fibrinogen with its platelet receptor: differential effects of a and γ chain fibrinogen peptides on the glycoprotein IIb-IIIa complex. J Biol Chem 263:12,948-12,953.
3. Bennett JS, Kolodziej MA, Vilaire G, Poncz M: 1993. Determinants of the intracellular fate of truncated forms of the platelet glycoproteins IIb and IIIa. J Biol Chem 268:1-6.
4. Bormann B, Engelman D: 1992. Intramembrane helix-helix association in oligomerization and transmembrane signaling. Annu Rev Biophys Biomol Struct 21:223-242.
5. Charo IF, Nannizzi L, Phillips DR, Hsu MA, Scarborough RM: 1991. Inhibition of fibrinogen binding to GPIIb-IIIa by a GP IIIa peptide. J Biol Chem 266:1415-1421.
6. 3 (glycoprotein IIb-IIIa) in a variant of Glanzmann thrombasthenia. Proc Natl Acad Sci USA 89:10,169-10,173.
7. Cierniewski C, Haas T, Smith J, Plow E: 1994. Characterization of cation-binding sequences in the platelet integrin GPIIb-IIIa (alpha IIb beta 3) by terbium luminescence. Biochemistry 33:12,238-12,246.
8. Clark EA, Shattil SJ, Brugge JS: 1994. Regulation of protein tyrosine kinases in platelets. Trends Biochem Sci 19:464-469.
9. D'Souza SE, Ginsberg MH, Burke TA, Lam SC-T, Plow EF: 1988. Localization of an Arg-Gly-Asp recognition site within an integrin adhesion receptor. Science 242:91-93.
10. D'Souza SE, Ginsberg MH, Burke TA, Plow EF: 1990. The ligand binding site of the platelet integrin receptor GPIIb-IIIa is proximal to the second calcium binding domain of its a subunit. J Biol Chem 265: 3440-3446.
11. D'Souza S, Haas T, Piotrowicz R, et al.: 1994. Ligand and cation binding are dual functions of a discrete segment of the integrin beta 3 subunit: cation displacement is involved in ligand binding. Cell 79:659-667.
12. Farrell DH, Thiagarajan P, Chung DW, Davie EW: 1992. Role of fibrinogen a and γ chain sites in platelet aggregation. Proc Natl Acad Sci USA 89:10,729-10,732.
13. Filardo EJ, Cheresh DA: 1994. A beta turn in the cytoplasmic tail of the integrin alpha v subunit influences conformation and ligand binding of alpha v beta 3. J Biol Chem 269: 4641-4647.
14. Gartner TK, Bennett JS: 1985. The tetrapeptide analogue of the cell attachment site of fibronectin inhibits platelet aggregation and fibrinogen binding to activated platelets. J Biol Chem 260:11,891-11,894.
15. 2+-binding properties of the platelet glycoprotein IIb ligand-interacting domain. J Biol Chem 267: 1001-1007.
16. Hillery CA, Smyth SS, Parise LV: 1991. Phosphorylation of human platelet glycoprotein Ilia (GPIIIa): dissociation from fibrinogen receptor activation and phosphorylation of GPIIIa in vitro. J Biol Chem 266:14,663-14,669.
17. Hughes P, O'Toole T, Ylanne J, Shattil S, Ginsberg M: 1995. The conserved membrane-proximal region of an integrin cytoplasmic domain specifies ligand binding affinity. J Biol Chem 270:12,411-12,417.
18. Kassner PD, Kawaguchi S, Hemler ME: 1994. Minimum α chain cytoplasmic tail sequence needed to support integrin-mediated adhesion. J Biol Chem 269:19,859-19,867.
19. Kloczewiak M, Timmons S, Lukas TJ, Hawiger J: 1984. Platelet receptor recognition site on human fibrinogen: synthesis and structure-function relationships of peptides corresponding to the carboxy-terminal segment of the γ chain. Biochemistry 23:1767-1774.
20. Kolodziej MA, Vilaire G, Gonder D, Poncz M, Bennett JS: 1991. Study of the endoproteolytic cleavage of platelet glycoprotein IIb using oligonucleotide-mediated mutagenesis. J Biol Chem 266:23,499-23,504.
21. Kouns W, Steiner B, Kunicki T, et al.: 1994. Activation of the fibrinogen binding site on platelets isolated from a patient with the Strasbourg I variant of Glanzmann's thrombasthenia. Blood 84:1108-1015.
22. 214Trp mutation. J Clin Invest 89:1995-2004.
23. Lefkovits J, Plow EF, Topol EJ: 1993. Platelet glycoprotein IIb/IIIa receptors in cardiovascular medicine. N Engl J Med 332:1553-1559.
24. Loftus JC, O'Toole TE, Plow EF, Glass A, Frelinger AL III, Ginsberg MH: 1990. A β3 integrin mutation abolishes ligand binding and alters divalent cation-dependent conformation. Science 249:915-918.
25. Loh E, Beaverson K, Vilaire G, Qi W, Poncz M, Bennett JS: 1995. Agonist-stimulated ligand binding by the platelet integrin αIIbβ3 in a lymphocyte expression system. J Biol Chem 270:18,631-18,636.
26. Morii N, Teru-uchi T, Tominaga T, et al.: 1992. A rho gene product in human blood platelets. II. Effects of the ADP-ribosylation by botulinum C3 ADP-ribosyltransferase on platelet aggregation. J Biol Chem 267:20,921-20,926.
27. O'Toole TE, Katagiri Y, Faull RJ, et al.: 1994. Integrin cytoplasmic domains mediate inside-out signal transduction. J Cell Biol 124:1047-1059.
28. O'Toole T, Ylanne J, Culley B: 1995. Regulation of integrin affinity states through an NPXY motif in the beta subunit cytoplasmic domain. J Biol Chem 270:8553-8558.
29. Otey CA, Vasquez GB, Burridge K, Erickson BW: 1993. Mapping of the alpha-actinin binding site within the beta 1 integrin cytoplasmic domain. J Biol Chem 268:21,193-21,197.
30. Poncz M, Salahandrin R, Coller BS, et al.: 1994. Glanzmann thrombasthenia secondary to a Gly273-Asp mutation adjacent to the first calcium-binding domain of platelet glycoprotein IIb. J Clin Invest 93:172-179.
31. Reszka AA, Hayashi Y, Horwitz AF: 1992. Identification of amino acid sequences in the integrin beta 1 cytoplasmic domain implicated in cytoskeletal association. J Cell Biol 117:1321-1330.
32. 3) mediated by fibrinogen and glycoprotein Ib-von Willebrand factor. J Biol Chem 267:11,300-11,306.
33. Shattil SJ, Hoxie JA, Cunningham M, Brass LF: 1985. Changes in the platelet membrane glycoprotein IIb-IIIa complex during platelet activation. J Biol Chem 260:11,107-11,114.
34. Sims PJ, Ginsberg MH, Plow EF, Shattil SJ: 1991. Effect of platelet activation on the conformation of the plasma membrane glycoprotein IIb-IIIa complex. J Biol Chem 266:7345-7352.
35. Strynadka NCJ, James MNG: 1989. Crystal structures of the helix-loop-helix calcium-binding proteins. Annu Rev Biochem 58:951-998.
36. Veklich Y, Gorkun O, Medved L, Nieuwenhuizen W, Weisel J: 1993. Carboxyl-terminal portions of the alpha chains of fibrinogen and fibrin: localization by electron microscopy and the effects of isolated alpha C fragments on polymerization. J Biol Chem 268:13,577-13,585.
37. 3 complex in a variant type of Glanzmann thrombasthenia [abst]. Blood 84(Suppl)1:244a.
38. Weisel JW, Nagaswami C, Vilaire G, Bennett JS: 1992. Examination of the platelet membrane glycoprotein IIb/IIIa complex and its interaction with fibrinogen and other ligands by electron microscopy. J Biol Chem 267:16,637-16,643.
39. Wilcox DA, Wautier JL, Pidard D, Newman PJ: 1994. A single amino acid substitution flanking the fourth calcium binding domain of alpha IIb prevents maturation of the alpha IIb beta 3 integrin complex. J Biol Chem 269:4450-4457.
40. Wilcox DA, Paddock CM, Lyman S, Gill JC, Newman PJ: 1995. Glanzmann thrombasthenia resulting from a single amino acid substitution between the second and third calcium-binding domains of GPIIb: role of the GPIIb amino terminus in integrin subunit association. J Clin Invest 95:1553-1560.