Inhibition of potassium currents by the antiarrhythmic drug E4031 in rat taste receptor cells

Neuroscience Letters

Volumn 204, Issue 3, 1996, Pages 149-152

  Sun, Xiao Dong ^a   Herness, M Scott ^a  

^a BALL STATE UNIVERSITY   (United States)

Author keywords

Action potential; Class III antiarrthymic; E4031; Gustation; Potassium channels; Taste; Transduction

Indexed keywords

1 [2 (6 METHYL 2 PYRIDYL)ETHYL] 4 (4 METHYLSULFONYLAMINOBENZOYL)PIPERIDINE; ANTIARRHYTHMIC AGENT; POTASSIUM CHANNEL;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; FEMALE; MALE; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; TASTE; TASTE BUD;

EID: 0030063328     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3940(96)12343-0     Document Type: Article

References (16)

1. Avenet, P. and Lindemann, B., Patch-clamp study of isolated taste receptor cells of the frog, J. Membr. Biol., 97 (1987) 223-240.
2. Béhé, P., DeSimone, J.A., Avenet, P. and Lindemann, B., Membrane currents in taste cells of the rat fungiform papilla: evidence for two types of Ca currents and inhibition of K currents by saccharin, J. Gen. Physiol., 96 (1990) 1061-1084.
3. Bigiani, A. and Roper, S., Identification of electrophysiologically distinct cell subpopulations in Necturus taste buds, J. Gen. Physiol., 102 (1993) 143-170.
4. Chen, Y. Sun, X.-D. and Herness, M.S., Characteristics of action potentials and their underlying outward currents in rat taste cells, J. Neurophysiol., 75 (2) (1996) 820-831.
5. Doupnik, C.A., Davidson, N. and Lester, H.A., The inward rectifier potassium channel family, Curr. Biol., 5 (1995) 268-277.
6. K, by flecainide and E4031 in cat ventricular myocytes, Circulation, 82 (1990) 289-293.
7. Herness, M.S., A dissociation procedure for mammalian laste cells, Neurosci. Lett., 106 (1989) 60-64.
8. Herness, M.S. and Sun, X-.D., Voltage-dependent sodium currents recorded from dissociated rat taste cells, J. Membr. Biol., 146 (1995) 73-84.
9. Liu, Y., Taffet, S.M., Anumonwe, J.M. and Delmar, M., Characterization of an E4031-sensitive potassium current in quiescent AT-1 cells, J. Cardiovasc. Electrophysiol., 5 (1990) 1017-1030.
10. Kinnamon, S.C., and Roper, S.D., Membrane properties of isolated mudpuppy taste cells, J. Gen. Physiol., 91 (1988) 351-371.
11. Roper, S.D. and McBride, D.W., Distribution of ion channels on taste cells and its relationship to chemosensory transduction, J. Membr. Biol., 109 (1989) 29-39.
12. + current: differential sensitivity to block by class III antiarrhythmic agents, J. Gen. Physiol., 96 (1990) 195-215.
13. + current is composed of two currents in guinea pig atrial cells, Am. J. Physiol., 260 (1991) H393-H399.
14. Sugimoto, K. and Teeter, J.H., Voltage-dependent ionic currents in taste receptor cells of the larval tiger salamander, J. Gen. Physiol., 96 (1990) 809-834.
15. Ks and mediates species-specific responses to protein kinase C, Proc. Natl. Acad. Sci. USA, 90 (1993) 11528-11532.
16. Wu, B., Sato, T., Kiyoshe, T. and Arita, M., Blockade of 2,4-nitrophenol-induced ATP-sensitive potassium current in guinea pig ventricular myocytes by class I antiarrhythmic drugs, Cardiovasc. Res., 26 (1992) 1095-1101.