The use of oral ganciclovir in the treatment of cytomegalovirus retinitis in patients with AIDS

CMAJ. Canadian Medical Association Journal

Volumn 154, Issue 3, 1996, Pages 363-368

  Ward Able, Clive ^a,e   Phillips, Peter ^b,c   Tsoukas, Christos M ^d  

^a Hoffmann La Roche (Canada)   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c ST PAUL S HOSPITAL   (Canada)

^d MCGILL UNIVERSITY   (Canada)

^e Hoffmann La Roche Ltd   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; FOSCARNET; GANCICLOVIR;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; COST EFFECTIVENESS ANALYSIS; CYTOMEGALOVIRUS INFECTION; DRUG BIOAVAILABILITY; DRUG SAFETY; HIGH RISK PATIENT; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MAINTENANCE THERAPY; MEDICAL DECISION MAKING; NEUTROPENIA; ORAL DRUG ADMINISTRATION; PATIENT COMPLIANCE; PRACTICE GUIDELINE; QUALITY OF LIFE; RETINITIS; REVIEW;

EID: 0030063298     PISSN: 08203946     EISSN: 14882329     Source Type: Journal    
DOI: None     Document Type: Review

References (24)

1. Palestine AG, Rodrigues MM, Macher AM et al: Ophthalmic involvement in acquired immunodeficiency syndrome. Ophthalmology 1984; 91: 1092-1099
2. Jabs DA, Enger C, Bartlett JG: Cytomegalovirus retinitis and acquired immunodeficiency syndrome. Arch Opthalmol 1989; 107: 75-80
3. Jabs DA, Green WR, Fox R et al: Ocular manifestations of acquired immune deficiency syndrome. Ophthalmology 1989; 96: 1092
4. Drew WL, Buhles W, Erlich K: Management of herpes virus infections (CMV, HSV, VZV). In Sande MA, Volberding PA (eds): The Medical Management of AIDS, 3rd ed, WB Saunders, Philadelphia: 359-382
5. Jacobson LA, O'Donnell JJ, Mills J: Foscarnet treatment of cytomegalovirus retinitis in patients with the acquired immunodeficiency syndrome. Antimicrob Agents Chemother 1989; 33: 736-741
6. Spector SA, Busch DF, Follansbee S et al. Pharmacokinetic, safety, and antiviral profiles of oral ganciclovir in persons infected with human immunodeficiency virus: a phase I/II study. J Infect Dis 1995; 171: 1431-1437
7. Cytovene Product Monograph Hoffman-LaRoche (Canada). Oct 3, 1995
8. Drew WL, Ives D, Lalezari JP et al: Oral ganciclovir as maintenance treatment for cytomegalovirus retinitis in patients with AIDS. N Engl J Med 1995; 333: 615-620
9. Squires KE, Stempien MJ, Shadman A et al: Oral ganciclovir versus intravenous ganciclovir maintenance therapy for cytomegalovirus retinitis in patients with AIDS: preliminary results of a phase III study [abstract 540]. In The First National Conference on Human Retroviruses and Related Injections, Dec 12-16, 1993, Washington (unpublished, Apr 1995)
10. Oral Ganciclovir European and Australian Cooperative Study Group: Intravenous versus oral ganciclovir: European/Australian comparative study of efficacy and safety in the prevention of cytomegalovirus retinitis recurrence in patients with AIDS. AIDS 1995; 9: 471-477
11. Jefferiss Wing Therapeutics and Protocols Group: New developments in HIV therapy: oral ganciclovir, a rational approach to prescribing. St Mary's Hospital, London (unpublished observations, Apr 1995)
12. Katlama C: Cytomegalovirus infection in acquired immunedeficiency syndrome. J Med Virol 1993; 1 (suppl): 128-133
13. Drew WL: Cytomegalovirus infection in patients with AIDS. Clin Inject Dis 1992; 14: 608-615
14. Pepose JS, Holland GN, Nestor MS et al: Acquired immune deficiency syndrome: pathogenetic mechanisms of ocular disease. Ophthalmology 1985; 92: 472-484
15. Holland GN, Pepose JS, Pettit TH et al: Acquired immune deficiency syndrome: ocular manifestations. Ophthalmology 1983; 90: 859-873
16. Laskin OL, Cederberg DM, Mills J et al: Ganciclovir for the treatment and suppression of serious infections caused by cytomeaglovirus. Am J Med 1987; 83: 201-207
17. Collaborative DHPG Treatment Study Group: Treatment of serious cytomegalovirus infections with 9-(1,3-dihydroxy-2-propoxymethyl) guanine in patients with AIDS and other immunodeficiencies. N Engl J Med 1986; 314: 801-805
18. Jacobson MA, O'Donnell JJ, Brodie HR et al: Randomized prospectice trial of ganciclovir maintenance therapy for cytomegalovirus retinitis. J Med Virol 1988; 25: 339-349
19. Spector SA, Weingeist T, Pollard RB et al: A randomized, controlled study of IV ganciclovir therapy for cytomegalovirus peripheral retinitis in patients with AIDS. J Infect Dis 1993; 168: 557-563
20. Palestine AG, Polis MA, DeSmet MD et al: A randomized, controlled trial of foscarnet in the treatment of cytomegalovirus retinitis in patients with AIDS. Ann Intern Med 1991; 115: 665-673
21. Holland GN, Sidikaro Y, Kreiger AE et al: Treatment of cytomegalovirus retinopathy with ganciclovir. Ophthalmology 1987; 94: 815-823
22. Jabs DA, Newman C, De Bustros S et al: Treatment of cytomegalovirus retinitis with ganciclovir. Ophthalmology 1987; 94: 824-830
23. Follansbee S, Stempien MJ, and Syntex Cooperative Oral Ganciclovir Study Group: Safety of oral ganciclovir for maintenance treatment of CMV retinitis [abstract H29]. 34th Interscience Conference on Antimicrobial Agents and Chemotheraphy, Orlando, Fla, Oct 1994
24. Rachlis A, Smaill F: Incremental cost-effectiveness analysis of IV ganciclovir versus oral ganciclovir in maintenance treatment of CMV retinitis in patients with AIDS. Personal communications, Dr. A. Rachlis, Sunnybrook Health Science Centre, North York, Ont, Nov 24, 1995