Chlorpromazine stimulatory effect on iron uptake by rat brain synaptosomes

Biochemical Pharmacology

Volumn 51, Issue 3, 1996, Pages 331-337

  Demasi, Marilene ^a   Bechara, Etelvino J H ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

chlorpromazine; synaptosomal iron uptake; transferrin

Indexed keywords

CALCIUM; CHLORPROMAZINE; DOPAMINE 2 RECEPTOR; FERROUS CITRATE FE 59; IRON; TRANSFERRIN FE 59;

ABSORPTION SPECTROSCOPY; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN SYNAPTOSOME; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINERGIC TRANSMISSION; EXTRAPYRAMIDAL SYMPTOM; FLUORESCENCE; IRON TRANSPORT; NONHUMAN; PRIORITY JOURNAL; RAT; TARDIVE DYSKINESIA;

EID: 0030062836     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(95)02187-6     Document Type: Article

References (24)

1. Youdim MBH, Green AR, Bloomfield MR, Mitchell BD, Heal DJ and Grahame-Smith DG, The effects of iron deficiency on brain biogenic monoamine biochemistry and function in rats. Neuropharmacology 19: 259-267, 1980.
2. Ashkenazi R, Ben-Shachar D and Youdim MBH, Nutritional iron and dopamine binding sites in the rat brain. Pharmacol Biochem Behav 17 (Suppl 1): 43-47, 1982.
3. Ben-Shachar D, Ashkenazi R and Youdim MBH, Long term consequences of early iron deficiency on dopaminergic neurotransmission. Int J Dev Neurosci 4: 91-98, 1986.
4. 2 receptor supersensitivity. J Neurochem 54: 1136-1141, 1990.
5. 2 receptor supersensitivity by chronic iron salt treatment. Eur J Pharmacol 202: 177-183, 1991.
6. Campbell WG, Raskind MA, Gordon T and Shaw CM, Iron pigment in the brain of a man with tardive dyskinesia. Am J Psychiat 142: 362-364, 1985.
7. Hunter R, Blackwood W and Smith MCJ, Neuropathological findings in three cases of persistent dyskinesia following phenothiazine medication. J Neural Sci 7: 763-773, 1968.
8. Weiner WJ, Nausieda PA and Klawans HL, Effect of chlorpromazine on central nervous system concentrations of manganese, iron and copper. Life Sci 20: 1181-1186, 1977.
9. Borg DC and Cotzias GC, Interaction of trace metals with phenothiazine drug derivatives, I. Structure-reactivity correlations. Proc Natl Acad Sci USA 48: 617-623, 1962.
10. 3 uptake. J Neurochem 62: 1112-1118, 1994.
11. Morris CM, Candy JM, Keith AB, Oakley AE, Taylor GA, Pullen RGL, Bloxham CA, Gocht A and Edwardson JA, Brain iron homeostasis. J Inorg Biochem 47: 257-265, 1992.
12. Swaiman KF and Machen VL, Iron uptake by mammalian cortical neurons. Ann Neurol 16: 66-70, 1984.
13. Giometto B, Bozza F, Argentiero V, Gallo P, Pagni S, Piccino MG and Tavolato B, Transferrin receptors in rat central nervous system. An immunocytochemical study. J Neurol Sci 98: 81-90, 1990.
14. Cotman CW and Matthews DA, Synaptic plasma membranes from rat brain synaptosomes: Isolation and partial characterization. Biochim Biophys Acta 249: 380-394, 1971.
15. Lowry OH, Rosebrough NJ, Farr AL and Randall RJ, Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265-275, 1951.
16. Konopka K and Romslo I, Studies on the mechanism of pyrophosphate-mediated uptake of iron from transferrin by isolated rat-liver mitochondria. Eur J Biochem 117: 239-244, 1981.
17. Nilsen T, Effects of calcium on hepatocyte iron uptake from transferrin, iron-pyrophosphate and iron-ascorbate. Biochim Biophys Acta 1095: 39-45, 1991.
18. Nachshein DA, Regulation of cytosolic calcium concentration in presynaptic nerve endings isolated from rat brain. J Physiol (Lond) 363: 87-101, 1985.
19. Morgan EH, Calcium chelators induce association with the detergent-insoluble cytoskeleton and functional inactivation of the transferrin receptor in reticulocytes. Biochim Biophys Acta 981: 121-129, 1989.
20. Lieber MR, Lange Y, Weinstein RS and Steck TL, Interaction of chlorpromazine with the human erythrocyte membrane. J Biol Chem 259: 9225-9234, 1984.
21. Luxnat M and Galla HJ, Partition of chlorpromazine into lipid bilayer membranes: The effect of membrane structure and composition. Biochim Biophys Acta 856: 274-282, 1986.
22. Grootveld M, Bell JD, Halliwell B, Aruoma OI, Bomford A and Sadler PJ, Non-transferrin-bound iron in plasma or serum from patients with idiopathic hemochromatosis. Characterization by high performance liquid chromatography and nuclear magnetic resonance spectroscopy. J Biol Chem 264: 4417-4422, 1989.
23. Spiro TG, Pape L and Saltman P, The hydrolytic polymerization of ferric citrate The chemistry of the polymer. J Am Chem Soc 89: 5555-5559, 1967.
24. Faller B and Nick H, Kinetics and mechanism of iron(III) removal from citrate by desferrioxamine B and 3-hydroxy-1,2-dimethyl-4-pyridone. J Am Chem Soc 116: 3860-3864, 1994.