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Volumn 10, Issue 2, 1996, Pages 159-165

The prognostic significance of serum viral load, codon 215 reverse transcriptase mutation and CD4+ T cells on progression of HIV disease in a double-blind study of thymopentin

Author keywords

Asymptomatic; Disease progression; HIV RNA; Resistance; Therapy; Thymopentin; Viral load; Zidovudine

Indexed keywords

ANTIGEN P24; ANTIVIRUS AGENT; CD4 ANTIGEN; IMMUNOSTIMULATING AGENT; RNA DIRECTED DNA POLYMERASE; THYMOPENTIN; VIRUS ENZYME; VIRUS RNA; ZIDOVUDINE;

EID: 0030062761     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-199602000-00005     Document Type: Article
Times cited : (24)

References (52)
  • 1
    • 0024361219 scopus 로고
    • CD4 counts as predictors of opportunistic pneumonias in human immunodeficiency virus (HIV) infection
    • Masur H, Ognibene FP, Yarchoan R, et al.: CD4 counts as predictors of opportunistic pneumonias in human immunodeficiency virus (HIV) infection. Ann Intern Med 1989, 111:223-231.
    • (1989) Ann Intern Med , vol.111 , pp. 223-231
    • Masur, H.1    Ognibene, F.P.2    Yarchoan, R.3
  • 2
    • 0026756378 scopus 로고
    • Predictors of HIV-1 disease progression in early- and late-stage patients: The US Army natural history cohort
    • Gardner LI Jr, Brundage JF, McNeil JG, et al.: Predictors of HIV-1 disease progression in early- and late-stage patients: the US Army natural history cohort. J Acquir Immune Defic Syndr 1992, 5:782-793.
    • (1992) J Acquir Immune Defic Syndr , vol.5 , pp. 782-793
    • Gardner Jr., L.I.1    Brundage, J.F.2    McNeil, J.G.3
  • 3
    • 0028236515 scopus 로고
    • Characteristics of long-term asymptomatic infection with human immunodeficiency virus type 1 in men with normal and low CD4+ cell counts
    • Keel IPM, Krol A, Klein MR, et al.: Characteristics of long-term asymptomatic infection with human immunodeficiency virus type 1 in men with normal and low CD4+ cell counts. J Infect Dis 1994, 169:1236-1243.
    • (1994) J Infect Dis , vol.169 , pp. 1236-1243
    • Keel, I.P.M.1    Krol, A.2    Klein, M.R.3
  • 4
    • 0027054043 scopus 로고
    • CD4 lymphocyte decline and survival in human immunodeficiency virus infection
    • Drabick JJ, Williams WJ, Tang DB, Sun W, Chung RC, Military Medical Consortium for Applied Retroviral Research: CD4 lymphocyte decline and survival in human immunodeficiency virus infection. AIDS Res Hum Retroviruses 1992, 8:2039-2047.
    • (1992) AIDS Res Hum Retroviruses , vol.8 , pp. 2039-2047
    • Drabick, J.J.1    Williams, W.J.2    Tang, D.B.3    Sun, W.4    Chung, R.C.5
  • 5
    • 0026751270 scopus 로고
    • Biphasic rate of CD4+ cell count decline during progression to AIDS correlates with HIV-1 phenotype
    • Schellekens PTA, Tersmette M, Roos MTL, et al.: Biphasic rate of CD4+ cell count decline during progression to AIDS correlates with HIV-1 phenotype. AIDS 1992, 6:665-669
    • (1992) AIDS , vol.6 , pp. 665-669
    • Schellekens, P.T.A.1    Tersmette, M.2    Roos, M.T.L.3
  • 6
    • 0027257415 scopus 로고
    • Rate of CD4 cell decline and prediction of survival in zidovudine-treated patients
    • Easterbrook PJ, Emami J, Gazzard B: Rate of CD4 cell decline and prediction of survival in zidovudine-treated patients. AIDS 1993, 7:959-967.
    • (1993) AIDS , vol.7 , pp. 959-967
    • Easterbrook, P.J.1    Emami, J.2    Gazzard, B.3
  • 7
    • 0026446532 scopus 로고
    • Association of antibody to human immunodeficiency virus type 1 core protein (p24), CD4+ lymphocyte number, and AIDS-free time
    • Farzadegan H, Chmiel JS, Odaka N, et al.: Association of antibody to human immunodeficiency virus type 1 core protein (p24), CD4+ lymphocyte number, and AIDS-free time. J Infect Dis 1992, 166:1217-1222.
    • (1992) J Infect Dis , vol.166 , pp. 1217-1222
    • Farzadegan, H.1    Chmiel, J.S.2    Odaka, N.3
  • 8
    • 0028847578 scopus 로고
    • Virologic and immunologic characterization of long-term survivors of human immunodeficiency virus type 1 infection
    • Cao Y, Qin L, Zhang L, Safrit J, Ho D: Virologic and immunologic characterization of long-term survivors of human immunodeficiency virus type 1 infection. N Engl J Med 1995, 332:201-208.
    • (1995) N Engl J Med , vol.332 , pp. 201-208
    • Cao, Y.1    Qin, L.2    Zhang, L.3    Safrit, J.4    Ho, D.5
  • 9
    • 0028861377 scopus 로고
    • Studies in subjects with long-term nonprogressive human immunodeficiency virus infection
    • Pantaleo G, Menzo S, Vaccarezza M, et al.: Studies in subjects with long-term nonprogressive human immunodeficiency virus infection. N Engl J Med 1995, 332:209-216.
    • (1995) N Engl J Med , vol.332 , pp. 209-216
    • Pantaleo, G.1    Menzo, S.2    Vaccarezza, M.3
  • 10
    • 0028914761 scopus 로고
    • Predictors for non-and slow progression in human immunodeficiency virus (HIV) type 1 infection: Low viral RNA copy numbers in serum and maintenance of high HIV-1 p24-specific but not V3-specific antibody levels
    • Hogervorst E, Jurriaans S, de Wolf F, et al.: Predictors for non-and slow progression in human immunodeficiency virus (HIV) type 1 infection: low viral RNA copy numbers in serum and maintenance of high HIV-1 p24-specific but not V3-specific antibody levels. J Infect Dis 1995, 171:811-821.
    • (1995) J Infect Dis , vol.171 , pp. 811-821
    • Hogervorst, E.1    Jurriaans, S.2    De Wolf, F.3
  • 11
    • 0028964251 scopus 로고
    • Prediction of progression to AIDS with serum HIV-1 RNA and CD4 count
    • Loveday C, Hill A: Prediction of progression to AIDS with serum HIV-1 RNA and CD4 count. Lancet 1995, 345:790-791.
    • (1995) Lancet , vol.345 , pp. 790-791
    • Loveday, C.1    Hill, A.2
  • 12
    • 0028000730 scopus 로고
    • Evaluation of proviral copy number and plasma RNA level as early indicators of progression in HIV-1 infection: Correlation with virological and immunological markers of disease
    • Verhofstede C, Reniers S, Van Wanzeele F, Plum J: Evaluation of proviral copy number and plasma RNA level as early indicators of progression in HIV-1 infection: correlation with virological and immunological markers of disease. AIDS 1994, 8:1421-1427.
    • (1994) AIDS , vol.8 , pp. 1421-1427
    • Verhofstede, C.1    Reniers, S.2    Van Wanzeele, F.3    Plum, J.4
  • 13
    • 0027537480 scopus 로고
    • Prognostic value of HIV-1 syncytium-inducing phenotype for rate of CD4+ cell depletion and progression to AIDS
    • Koot M, Keel IPM, Vos AHV, et al.: Prognostic value of HIV-1 syncytium-inducing phenotype for rate of CD4+ cell depletion and progression to AIDS. Ann Intern Med 1993, 118:681-688.
    • (1993) Ann Intern Med , vol.118 , pp. 681-688
    • Koot, M.1    Keel, I.P.M.2    Vos, A.H.V.3
  • 14
    • 0027488802 scopus 로고
    • A cross-sectional comparison of persons with syncytium-and non-syncytium-inducing human immunodeficiency virus
    • Bozzette SA, McCutchan JA, Spector SA, Wright B, Richman DD: A cross-sectional comparison of persons with syncytium-and non-syncytium-inducing human immunodeficiency virus. J Infect Dis 1993, 168:1374-1379.
    • (1993) J Infect Dis , vol.168 , pp. 1374-1379
    • Bozzette, S.A.1    McCutchan, J.A.2    Spector, S.A.3    Wright, B.4    Richman, D.D.5
  • 17
    • 0025212296 scopus 로고
    • 2-microglobulin level and CD4 lymphocyte count to predict development of acquired immunodeficiency syndrome in persons with human immunodeficiency virus infection
    • 2-microglobulin level and CD4 lymphocyte count to predict development of acquired immunodeficiency syndrome in persons with human immunodeficiency virus infection. Arch Intern Med 1990, 150:73-77.
    • (1990) Arch Intern Med , vol.150 , pp. 73-77
    • Anderson, R.E.1    Lang, W.2    Shiboski, S.3    Royce, R.4    Jewell, N.5    Winkelstein Jr., W.6
  • 18
    • 0027214548 scopus 로고
    • 2-microglobulin, immunoglobulin A and erythrocyte sedimentation rate
    • 2-microglobulin, immunoglobulin A and erythrocyte sedimentation rate. AIDS 1993, 7:813-821.
    • (1993) AIDS , vol.7 , pp. 813-821
    • Schwartländer, B.1    Bek, B.2    Skarabis, H.3
  • 19
    • 0026762698 scopus 로고
    • 2-microglobulin and prediction of progression to AIDS in HIV infection
    • 2-microglobulin and prediction of progression to AIDS in HIV infection. Lancet 1992, 339:1436-1440.
    • (1992) Lancet , vol.339 , pp. 1436-1440
    • Lifson, A.R.1    Hessol, N.A.2    Buchbinder, S.P.3
  • 20
    • 0028082258 scopus 로고
    • Quantitation of human immunodeficiency virus by culture and polymerase chain reaction in response to didanosine after long-term therapy with zidovudine
    • Katzenstein DA, Winters M, Bubp J, Israelski D, Winger E, Merigan TC: Quantitation of human immunodeficiency virus by culture and polymerase chain reaction in response to didanosine after long-term therapy with zidovudine. J Infect Dis 1994, 169:416-419.
    • (1994) J Infect Dis , vol.169 , pp. 416-419
    • Katzenstein, D.A.1    Winters, M.2    Bubp, J.3    Israelski, D.4    Winger, E.5    Merigan, T.C.6
  • 21
    • 0027481325 scopus 로고
    • Measurement of HIV virus load and genotypic resistance by gene amplification in asymptomatic subjects treated with combination therapy
    • Holodniy M, Katzenstein D, Winters M, et al.: Measurement of HIV virus load and genotypic resistance by gene amplification in asymptomatic subjects treated with combination therapy. J Acquir Immune Defic Syndr 1993, 6:366-369.
    • (1993) J Acquir Immune Defic Syndr , vol.6 , pp. 366-369
    • Holodniy, M.1    Katzenstein, D.2    Winters, M.3
  • 28
    • 0027403928 scopus 로고
    • CD4+ lymphocytes are an incomplete surrogate marker for clinical progression in persons with asymptomatic HIV infection taking zidovudine
    • Choi S, Lagakos SW, Schooley RT, Volberding PA: CD4+ lymphocytes are an incomplete surrogate marker for clinical progression in persons with asymptomatic HIV infection taking zidovudine. Ann Intern Med 1993, 118:674-680.
    • (1993) Ann Intern Med , vol.118 , pp. 674-680
    • Choi, S.1    Lagakos, S.W.2    Schooley, R.T.3    Volberding, P.A.4
  • 29
    • 0028344275 scopus 로고
    • Concorde: MRC/ANRS randomised double-blind controlled trial of immediate and deferred zidovudine in symptom-free HIV infection
    • Seligmann M, Warrell DA, Aboulker J-P, et al.: Concorde: MRC/ANRS randomised double-blind controlled trial of immediate and deferred zidovudine in symptom-free HIV infection. Lancet 1994, 343:871-881.
    • (1994) Lancet , vol.343 , pp. 871-881
    • Seligmann, M.1    Warrell, D.A.2    Aboulker, J.-P.3
  • 30
    • 0027463697 scopus 로고
    • A mutation of human immunodeficiency virus reverse transcriptase and decline in CD4 lymphocyte numbers in long-term zidovudine recipients
    • Kozal MJ, Shafer RW, Winters MA, Katzenstein DA, Merigan TC: A mutation of human immunodeficiency virus reverse transcriptase and decline in CD4 lymphocyte numbers in long-term zidovudine recipients. J Infect Dis 1993, 167:526-532.
    • (1993) J Infect Dis , vol.167 , pp. 526-532
    • Kozal, M.J.1    Shafer, R.W.2    Winters, M.A.3    Katzenstein, D.A.4    Merigan, T.C.5
  • 31
    • 0028340421 scopus 로고
    • HIV-1 syncytium-inducing phenotype, virus burden, codon 215 reverse transcriptase mutation and CD4 cell decline in zidovudine-treated patients
    • Kozal MJ, Shafer RW, Winters MA, et al.: HIV-1 syncytium-inducing phenotype, virus burden, codon 215 reverse transcriptase mutation and CD4 cell decline in zidovudine-treated patients. J Acquir Immune Def Syndr 1994, 7:832-838.
    • (1994) J Acquir Immune Def Syndr , vol.7 , pp. 832-838
    • Kozal, M.J.1    Shafer, R.W.2    Winters, M.A.3
  • 32
    • 0027516771 scopus 로고
    • Clinical correlates of in vitro HIV-1 resistance to zidovudine. Results of the multicentre Canadian AZT trial
    • Montaner JSG, Singer J, Schechter MT, et al.: Clinical correlates of in vitro HIV-1 resistance to zidovudine. Results of the multicentre Canadian AZT trial. AIDS 1993, 7:189-196.
    • (1993) AIDS , vol.7 , pp. 189-196
    • Montaner, J.S.G.1    Singer, J.2    Schechter, M.T.3
  • 33
    • 0026537499 scopus 로고
    • HIV-1 sensitivity to zidovudine and clinical outcome in children
    • Tudor-Williams G, St Clair MH, McKinney RE, et al.: HIV-1 sensitivity to zidovudine and clinical outcome in children. Lancet 1992, 339:15-19.
    • (1992) Lancet , vol.339 , pp. 15-19
    • Tudor-Williams, G.1    St Clair, M.H.2    McKinney, R.E.3
  • 34
    • 0028961822 scopus 로고
    • Prevalence and clinical significance of zidovudine resistance mutations in human immunodeficiency virus isolated from patients after long-term zidovudine treatment
    • Japour AJ, Welles S, D'Aquila RT, et al.: Prevalence and clinical significance of zidovudine resistance mutations in human immunodeficiency virus isolated from patients after long-term zidovudine treatment. J Infect Dis 1995, 171:1172-1179.
    • (1995) J Infect Dis , vol.171 , pp. 1172-1179
    • Japour, A.J.1    Welles, S.2    D'Aquila, R.T.3
  • 36
    • 0000482622 scopus 로고
    • Revision of the CDC surveillance case definition for acquired immunodeficiency syndrome
    • Centers for Disease Control: Revision of the CDC surveillance case definition for acquired immunodeficiency syndrome. MMWR 1987, 36:3-15.
    • (1987) MMWR , vol.36 , pp. 3-15
  • 37
    • 0025238899 scopus 로고
    • Zidovudine in asymptomatic human immunodeficiency virus infection. A controlled trial in persons with fewer than 500 CD4-positive cells per cubic millimeter
    • Volberding PA, Lagakos SW, Koch MA, et al.: Zidovudine in asymptomatic human immunodeficiency virus infection. A controlled trial in persons with fewer than 500 CD4-positive cells per cubic millimeter. N Engl J Med 1990, 322:941-949.
    • (1990) N Engl J Med , vol.322 , pp. 941-949
    • Volberding, P.A.1    Lagakos, S.W.2    Koch, M.A.3
  • 38
    • 0025314920 scopus 로고
    • The safety and efficacy of zidovudine (AZT) in the treatment of subjects with mildly symptomatic human immunodeficiency virus type 1 (HIV) infection. A double-blind, placebo-controlled trial
    • Fischl MA, Richman DD, Hansen N, et al.: The safety and efficacy of zidovudine (AZT) in the treatment of subjects with mildly symptomatic human immunodeficiency virus type 1 (HIV) infection. A double-blind, placebo-controlled trial. Ann Intern Med 1990, 112:727-737.
    • (1990) Ann Intern Med , vol.112 , pp. 727-737
    • Fischl, M.A.1    Richman, D.D.2    Hansen, N.3
  • 39
    • 0028069547 scopus 로고
    • Rapid and simple PCR assay for quantitation of human immunodeficiency virus type 1 RNA in plasma: Application to acute retroviral infection
    • Mulder J, McKinney N, Christopherson C, Sninsky J, Greenfield L, Kwok S: Rapid and simple PCR assay for quantitation of human immunodeficiency virus type 1 RNA in plasma: application to acute retroviral infection. J Clin Microbiol 1994, 32:292-300.
    • (1994) J Clin Microbiol , vol.32 , pp. 292-300
    • Mulder, J.1    McKinney, N.2    Christopherson, C.3    Sninsky, J.4    Greenfield, L.5    Kwok, S.6
  • 42
    • 0028937012 scopus 로고
    • Zidovudine resistance and HIV-1 disease progression during antiretroviral therapy
    • D'Aquila RT, Johnson VA, Welles SL, et al.: Zidovudine resistance and HIV-1 disease progression during antiretroviral therapy. Ann Intern Med 1995, 122:401-408.
    • (1995) Ann Intern Med , vol.122 , pp. 401-408
    • D'Aquila, R.T.1    Johnson, V.A.2    Welles, S.L.3
  • 43
    • 0023152332 scopus 로고
    • Effect of subcutaneous thymopentin treatment in drug addicts with persistent generalized lymphadenopathy
    • Barcellini W, Meroni PL, Frasca D, et al.: Effect of subcutaneous thymopentin treatment in drug addicts with persistent generalized lymphadenopathy. Clin Exp Immunol 1987, 67:537-543.
    • (1987) Clin Exp Immunol , vol.67 , pp. 537-543
    • Barcellini, W.1    Meroni, P.L.2    Frasca, D.3
  • 44
    • 0024571628 scopus 로고
    • Immunologic effects of long- term thymopentin treatment in patients with HIV-induced lymphadenopathy syndrome
    • Silvestris F, Gernone A, Frassanito MA, Dammacco F: Immunologic effects of long- term thymopentin treatment in patients with HIV-induced lymphadenopathy syndrome. J Lab Clin Med 1989, 113:139-144.
    • (1989) J Lab Clin Med , vol.113 , pp. 139-144
    • Silvestris, F.1    Gernone, A.2    Frassanito, M.A.3    Dammacco, F.4
  • 45
    • 0026475033 scopus 로고
    • Maintenance of CD4+ cells by thymopentin in asymptomatic HIV-infected subjects: Results of a double-blind, placebo-controlled study
    • Conant MA, Calabrese LH, Thompson SE, et al.: Maintenance of CD4+ cells by thymopentin in asymptomatic HIV-infected subjects: results of a double-blind, placebo-controlled study. AIDS 1992, 6:1335-1339.
    • (1992) AIDS , vol.6 , pp. 1335-1339
    • Conant, M.A.1    Calabrese, L.H.2    Thompson, S.E.3
  • 46
    • 0023088548 scopus 로고
    • In vivo immunopotentiating activity of thymopentin in aging humans: Increase of IL-2 production
    • Meroni PL, Barcellini W, Frasca D, et al.: In vivo immunopotentiating activity of thymopentin in aging humans: increase of IL-2 production. Clin Immunol Immunopathol 1987, 42:151-159.
    • (1987) Clin Immunol Immunopathol , vol.42 , pp. 151-159
    • Meroni, P.L.1    Barcellini, W.2    Frasca, D.3
  • 47
    • 0026667487 scopus 로고
    • Modulation of IL-2, IFN-γ, TNF-α and IL-4 production in mice of different ages by thymopentin
    • Cillari E, Milano S, Perego R, et al.: Modulation of IL-2, IFN-γ, TNF-α and IL-4 production in mice of different ages by thymopentin. Int J Immunopharmacol 1992, 14:1029-1035.
    • (1992) Int J Immunopharmacol , vol.14 , pp. 1029-1035
    • Cillari, E.1    Milano, S.2    Perego, R.3
  • 48
    • 0026750860 scopus 로고
    • Thymopentin reduces the susceptibility of aged mice to cutaneous leishmaniasis by modulating CD4 T-cell subsets
    • Cillari E, Milano S, Dieli M, et al.: Thymopentin reduces the susceptibility of aged mice to cutaneous leishmaniasis by modulating CD4 T-cell subsets. Immunology 1992, 76:362-366.
    • (1992) Immunology , vol.76 , pp. 362-366
    • Cillari, E.1    Milano, S.2    Dieli, M.3
  • 49
    • 0018909024 scopus 로고
    • 32-36 (TP5) on cytotoxic lymphocyte precursor units (CLP-U). I. Enhancement of splenic CLP-U in vitro and in vivo after suboptimal antigenic stimulation
    • 32-36 (TP5) on cytotoxic lymphocyte precursor units (CLP-U). I. Enhancement of splenic CLP-U in vitro and in vivo after suboptimal antigenic stimulation. J Immunol 1980, 124:1861-1865.
    • (1980) J Immunol , vol.124 , pp. 1861-1865
    • Lau, C.Y.1    Goldstein, G.2
  • 51
    • 0022349653 scopus 로고
    • Effect of thymopentin on the mortality and immune response after an experimental herpes simplex infection in mice
    • Cappel R, de Cuyper F, De Neef K, Höbel W, Bolla K: Effect of thymopentin on the mortality and immune response after an experimental herpes simplex infection in mice. Surv Immunol Res 1985, 4 (suppl 1):48-57.
    • (1985) Surv Immunol Res , vol.4 , Issue.1 SUPPL. , pp. 48-57
    • Cappel, R.1    De Cuyper, F.2    De Neef, K.3    Höbel, W.4    Bolla, K.5
  • 52
    • 0023915274 scopus 로고
    • Prostaglandin and lymphokine-mediated effects on natural killer cytotoxicity in human immunodeficiency virus-positive haemophiliacs
    • Ventura MT, Ottolenghi A, De Mitrio V, Antonaci S, Bonomo L: Prostaglandin and lymphokine-mediated effects on natural killer cytotoxicity in human immunodeficiency virus-positive haemophiliacs. Med Sci Res 1988, 16:639-640.
    • (1988) Med Sci Res , vol.16 , pp. 639-640
    • Ventura, M.T.1    Ottolenghi, A.2    De Mitrio, V.3    Antonaci, S.4    Bonomo, L.5


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