Resistance to activated protein C: A common anticoagulant deficiency in patients with venous leg ulceration

British Journal of Dermatology

Volumn 134, Issue 2, 1996, Pages 296-298

  Munkvad, S ^a,b   Jorgensen M ^a  

^a Bispebjerg University   (Denmark)

^b NONE   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED PROTEIN C;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DEEP VEIN THROMBOSIS; FEMALE; HUMAN; LEG ULCER; MALE; PRIORITY JOURNAL;

EID: 0030062677     PISSN: 00070963     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2133.1996.tb07617.x     Document Type: Article

References (14)

1. Burnand KG. The aetiology of venous ulceration. Acta Chir Scand 1988; 544 (Suppl.): 21-4.
2. Bauer G. The aetiology of leg ulcers and their treatment by resection of the popliteal vein. J Int Chir 1948; 8: 937-60.
3. Coffman JD. Cutaneous changes in peripheral vascular disease. In: Dermatology in General Medicine (Fitzpatrick TB, Eisen AZ, Wolff K et al., eds). New York: McGraw-Hill, 1993; 2077-104.
4. Jorgensen M, Petersen LC, Thorsen S. Purification and characterization of hereditary abnormal antithrombin III with impaired thrombin-binding. J Lab Clin Med 1984; 104: 245-56.
5. Munkvad S. Fibrinolysis in patients with acute ischaemic heart disease. With particular reference to tissue-type plasminogen activator treatment on coagulation, fibrinolysis and complement pathways. Dan Med Bull 1993; 40: 383-408.
6. Dahlbäck B, Carlsson M, Svensson PJ. Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C. Proc Natll Acad Sci USA 1993; 90: 1004-8.
7. Dahlbäck B, Hildebrand B. Inherited resistance to activated protein C is corrected by anticoagulant cofactor activity found to be a property of factor V. Proc Natl Acad Sci USA 1994; 91: 1396-1400.
8. Bertina RM, Koeleman BPC, Koster T et al. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 1994; 369: 64-7.
9. Koster T, Rosendaal FR, de Ronde H et al. Venous thrombosis due to poor anticoagulant response to activated protein C: Leiden Thrombophilia Study. N Engl J Med 1993; 342: 1503-6.
10. Svensson PJ, Dahlbäck B. Resistance to activated protein C as a basis for venous thrombosis. Lancet 1994; 330: 517-22.
11. Falanga V, Bontempo FA, Eaglstein WH. Protein C and protein S plasma levels in patients with lipodermatosclerosis and venous ulceration. Arch Dermatol 1990; 126: 1995-7.
12. Claudy AL, Mirshahi M, Soria C et al. Detection of undegraded fibrin and tumor necrosis factor in venous leg ulcers. J Am Acad Dermatol 1991; 25: 623-7.
13. Hansson C, Andersson E, Swanbeck G. A follow-up of leg and foot ulcer patients. Acta Derm Venereol (Stockh) 1987; 67: 496-500.
14. Phillips T, Stanton B, Provan A et al. A study of the impact of leg ulcers on quality of life: financial, social, and psychologic implications. J Am Acad Dermatol 1994; 31: 49-53.