The effect of lazaroid (U74500A), a novel inhibitor of lipid peroxidation, on 24-hour heart preservation: A study based on a working model using cross-circulated blood-perfused rabbit hearts

Transplantation

Volumn 61, Issue 2, 1996, Pages 194-199

  Nishida, Takahiro ^a   Morita, Shigeki ^a   Miyamoto, Kazuyuki ^a   Masuda, Munetaka ^a   Tominaga, Ryuji ^a   Kawachi, Yoshito ^a   Yasui, Hisataka ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

21 [4 [5,6 BIS(DIETHYLAMINO) 2 PYRIDYL] 1 PIPERAZINYL] 16ALPHA METHYLPREGNA 1,4,9(11) TRIENE 3,20 DIONE; LAZAROID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DRUG EFFICACY; GRAFT FAILURE; GRAFT SURVIVAL; HEART FAILURE; HEART PERFUSION; HEART PRESERVATION; HEART TRANSPLANTATION; INTRAVENOUS DRUG ADMINISTRATION; LIPID PEROXIDATION; NONHUMAN; PRIORITY JOURNAL; REPERFUSION INJURY;

ANIMALS; ANTIOXIDANTS; HEART; HEART TRANSPLANTATION; LIPID PEROXIDATION; ORGAN PRESERVATION; PERFUSION; PREGNATRIENES; RABBITS;

EID: 0030062484     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199601270-00005     Document Type: Article

References (32)

1. Rao PS, Cohen MV, Mueller HS. Production of free radicals and lipid peroxides in early experimental myocardial ischemia. J Mol Cell Cardiol 1983; 15: 713.
2. Meerson FZ, Kagan VE, Kozlov YP, et al. The role of lipid peroxidation in pathogenesis of ischemic damage and the antioxidant protection of the heart. Basic Res Cardiol 1982; 66: 397.
3. Badylak SF, Simmons A, Turek J, Babbs CF. Protection from reperfusion injury in the isolated rat heart by postischaemic deferoxamine and oxypurinol administration. Cardiovasc Res 1987; 21: 500.
4. Jolly SR, Kane WJ, Bailie MB, Abrams GD, Lucchesi BR. Canine myocardial reperfusion injury - its reduction by the combined administration of superoxide dismutase and catalase. Circ Res 1984; 54: 277.
5. Stewart JR, Crute SL, Loughlin V, Hess ML, Greenfield LJ. Prevention of free radical-induced myocardial reperfusion injury with allopurinol. J Thorac Cardiovasc Surg 1985; 90: 68.
6. Gross JM, Farber NE, Hardman HF, Warltier DC. Beneficial action of superoxide dismutase and catalase in stunned myocardium in dogs. Am J Physiol 1986; 250: H372.
7. Ryan TP, Steenwyk RC, Pearson PG, Petry TW. Inhibition of in vitro lipid peroxidation by 21-aminosteroids: evidence for differential mechanisms. Biochem Pharmacol 1993; 46: 87.
8. Braughler JM, Pregenzer JF, Chase RL, Duncan LA, Jacodsen EJ, McCall JM. Novel 21-amino steroids as inhibitors of iron-dependent lipid peroxidation. J Biol Chem 1987; 262: 10438.
9. Hall ED. Novel inhibitors of iron-dependent lipidoperoxidatin for neurodegenerative disorders. Ann Neurol 1992; 32: S137.
10. Shackleton CR, Ettinger SL, Scudamore CH, Toleikis OF, Keown PA. Effect of 21-aminosteroid, U74006F, on lipid peroxidation and glomerulotubular function following experimental renal ischemia. J Surg Res 1994; 57: 433.
11. Cosenza CA, Cramer DV, Cunneen SA, Tuso PJ, Wang HK, Makowka L. Protective effect of the lazaroid U74006F in cold ischemia-reperfusion injury of the liver. Hepatology 1994; 19: 418.
12. Aeba R, Killinger WA, Keenan RJ, et al. Lazaroid U74500A as an additive to University of Wisconsin solution for pulmonary grafts in the rat transport model. J Thorac Cardiovasc Surg 1992; 104: 1333.
13. Haynes J Jr, Seibert A, Bass JB, Taylor AE. U74500A inhibition of oxidant-mediated lung injury. Am J Physiol 1990; 259: H144.
14. Holzgrefe HH, Buchanan LV, Gibson JK, Effects of U74006F, A novel inhibitor of lipid peroxidation, in stunned reperfused canine myocardium. J Cardiovasc Pharmacol 1990; 15: 239.
15. Carrea FP, Lesnefsky EJ, Kaiser DG, Horwitz LD. The lazaroid U74500A, a 21-aminosteroid inhibitor of lipid peroxidation, attenuates myocardial injury from ischemia and reperfusion. J Cardiovasc Pharmacol 1992; 20: 230.
16. Miyamoto K, Morita S, Nishida T, et al. Pretreatment with lazaroid (U74500A) prevents ischemic and reperfusion injury in blood perfused rabbit hearts. Surg Forum 1994; 45: 230.
17. Hendry PJ, Anstadt MP, Plunkett MD, et al. Improved donor myocardial recovery with a new lazaroid lipid antiperoxidation in the isolated canine heart. J Heart Lung Transplant 1992; 11: 636.
18. Morita S, Kuboyama I, Asou T, et al. The effect of extraanatomic bypass on aortic input impedance studied in open chest dogs. J Thorac Cardiovasc Surg 1991; 102: 774.
19. Ohnishi N, Ohkawa H, Miike A, et al. A new assay method for lipid peroxidation using a methylene blue derivative. Biochem Int 1985; 10: 205.
20. Glantz SA, Slinker BK. Primer of applied regression and analysis of variance. New York: McGraw-Hill, 1990: 50.
21. McCord JM. Mechanisms of disease: oxygen derived free radicals in post ischemic tissue injury. N Engl J Med 1985; 312: 159.
22. Killinger WA Jr., Dorofi DB, Keagy BA, Johnson G Jr. Improvement of endothelial cell viability at 4°C by addition of lazaroid U74500A to preservation solutions. Transplantation 1992; 53: 983.
23. Hearse DJ, Kusama Y, Bernier M. Rapid electrophysiological changes leading to arrhythmia in the aerobic rat heart: photosensitization studies with rose Bengal-derived reactive oxygen intermediates. Circ Res 1989; 65: 146.
24. Masuda M, Chen CC, Cho BCG, Flameng W. Coronary reserve and contractile reserve in crystalloid- and blood-perfused rabbit hearts. Heart and Vessels 1994; 9: 175.
25. Goto Y, Slinker BK, LeWinter MM. Similar normalized Emax and O2 consumption-pressure-volume area relation in rabbit and dog. Am J Physiol 1988; 255: H366.
26. Oz MC, Pinsky DJ, Koga Shin, et al. Novel preservation solution permits 24-hour preservation in rat and baboon cardiac transplant models. Circulation 1993; 88: 291.
27. Nutt MP, Fields BL, Sebree LA, et al. Assessment of function, perfusion, metabolism, and histology in hearts preserved with University of Wisconsin solution. Circulation 1992; 86: 333.
28. Wicomb WN, Hill DJ, Collins GM. Twenty-four-hour ice storage of rabbit heart. J Heart Lung Transplant 1994; 13: 891.
29. Ploeg RJ, Goossens D, McAnulty JF, Southhard JH, Belzer FO. Successful 72-hour cold storage of dog kidneys with UW solution. Transplantation. 1988; 46: 191.
30. Wahlberg JA, Love R, Landegard L, Southard JH, Belzer FO. 72 hour preservation of canine pancreas. Transplantation. 1987; 43: 5.
31. Todo S, Nery J, Yanaga K, Podesto L, Gordon RD, Starzl TE. Extended preservation of human liver grafts with UW solution. JAMA 1989; 261: 711.
32. Jeevandam V, Barr ML, Auteri JS, et al. University of Wisconsin solution versus crystalloid cardioplegia for human donor heart preservation: a randomized blinded prospective clinical trial. J Thorac Cardiovasc Surg 1992; 103: 194.