Inhibition of ovulation by progestin analogs (agonists vs antagonists): Preliminary evidence for different sites and mechanisms of actions

Contraception

Volumn 53, Issue 1, 1996, Pages 55-64

  Heikinheimo, Oskari ^a,b   Gordon, Keith ^a   Williams, Robert F ^a   Hodgen, Gary D ^a  

^a EASTERN VIRGINIA MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

ovulation inhibition; primates; progestin agonist; progestin antagonist; RU486

Indexed keywords

ANDROSTENEDIONE; ANTIGESTAGEN; ESTRADIOL; GESTAGEN; GONADORELIN; LEVONORGESTREL; MIFEPRISTONE; PLACEBO; PROGESTERONE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; FEMALE; HORMONAL CONTRACEPTION; HYPOTHALAMUS HYPOPHYSIS GONAD SYSTEM; INTRAMUSCULAR DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MENSTRUAL CYCLE; MONKEY; NONHUMAN; OVULATION INHIBITION;

EID: 0030062351     PISSN: 00107824     EISSN: None     Source Type: Journal    
DOI: 10.1016/0010-7824(95)00255-3     Document Type: Article

References (39)

1. Goodman A, Hodgen G. Systemic versus intraovarian progesterone replacement after luteectomy in rhesus monkeys: differential patterns of gonadotropins and follicular growth. Endocrinology 1977;45:837-40.
2. Hodgen G. Selection and ovulation of the dominant follicle: role of intraovarian progesterone. In: van der Molen HJ, Klopper A, Lunenfeld B et al, eds. Hormonal factors in fertility, infertility and contraception, Amsterdam-Oxford-Princeton: Elsevier Science Publishing, 1981:28-44.
3. Goodman A, Hodgen G. Antifolliculogenic action of progesterone despite hypersecretion of FSH in monkeys. Am J Physiol 1982;243:E387-97.
4. Lobo R, Stanczyk F. New knowledge in the physiology of hormonal contraceptives. Am J Obstet Gynecol 1994;170:1499-507.
5. Liu J, Garzo G, Morris S, Stuenkel C, Ulmann A, Yen S. Disruption of follicular maturation and delay of ovulation after administration of the antiprogesterone RU486. J Clin Endocrinol Metab 1987;65:1135-40.
6. Luukkainen T, Heikinheimo O, Haukkamaa M, Lahteenmaki P. Inhibition of folliculogenesis and ovulation by the antiprogesterone RU486. Fertil Steril 1988; 49:961-3.
7. Danforth D, Dubois C, Ulmann A, Baulieu EE, Hodgen G. Contraceptive potential of RU486 by ovulation inhibition. Ill: Preliminary observations on once weekly oral administration. Contraception 1989;40:195-200.
8. Kettel M, Liu J, Murphy A, Ulmann A, Mortola J, Yen S. Endocrine responses to long-term administration of the antiprogesterone RU486 in patients with pelvic endometriosis. Fertil Steril 1991;56:402-7.
9. Collins R, Hodgen G. Blockade of the spontaneous mid-cycle gonadotropin surge in monkeys by RU486: a progesterone antagonist or agonist. J Clin Endocrinol Metab 1986;63:1270-6.
10. Wolf J, Hsiu J, Anderson T, Ulmann A, Baulieu EE, Hodgen G. Noncompetitive antiestrogenic effect of RU486 in blocking the estrogen-stimulated luteinizing hormone surge and the proliferative action of estradiol on endometrium in castrate monkeys. Fertil Steril 1989;52:1055-60.
11. Dimattina M, Albertson B, Seyler DE, Loriaux L, Falk RJ. Effect of the antiprogestin RU486 on progesterone production by cultured human granulosa cells: inhibition of the ovarian 3β-hydroxysteroid dehydrogenase. Contraception 1986;34:199-206.
12. Parinaud J, Perret B, Ribbes H, Vieitez G, Baulieu EE. Effects of RU486 on progesterone secretion by human preovulatory granulosa cells in culture. J Clin Endocrinol Metab 1990;70:1534-7.
13. Wolf J, Danforth D, Ulmann A, Baulieu EE, Hodgen G. Contraceptive potential of RU486 by ovulation inhibition: II. Suppression of pituitary gonadotropin secretion in vitro. Contraception 1989;40:185-98.
14. Heikinheimo O, Gordon K, Lahteenmaki P, Williams R, Hodgen G. Antiovulatory actions of RU486-pituitary is not a primary site of antiprogestin action in vivo. J Clin Endocrinol Metab 1995;1859-68.
15. Gordon K, Hodgen GD, Richardson DW. Post-partum lactational anovulation in a nonhuman primate (Macaca fascicularis): endogenous opiate mediation of suckling-induced hyperprolactinemia. J Clin Endocrinol Metab 1992;75:59-67.
16. Merriam G, Wachter K. Algorithms for the study of episodic hormone secretion. Am J Physiol 1982;243: E310-18.
17. Schreiber J, Nakamura K, Erickson G. Progestins inhibit FSH-stimulated steroidogenesis cultured rat granulosa cells. Mol Cel Endocrinol 1980;19:165-73.
18. Fortune J, Vincent S. Progesterone inhibits the induction of aromatase activity in rat granulosa cells in vitro. Biol Reprod 1983;28:1078-89.
19. Suzuki T, Sasano H, Kimura N, Tamura M, Fukaya T, Yajima A, Nagura H. Immunohistochemical localization of progesterone, androgen and oestrogen receptors in the human ovary during the menstrual cycle: relationship to expression of steroidogenic enzymes. Hum Reprod 1994;9:1589-94.
20. Park O-K, Mayo K. Transient expression of progesterone receptor messenger RNA in ovarian granulosa cells after the preovulatory luteinizing hormone surge. Mol Endocrinology 1991;5:967-78.
21. Chandrasekher A, Brenner R, Molskness T, Yu Q, Stouffer R. Titrating luteinizing hormone surge requirements for ovulatory changes in primate follicles. II. Progesterone receptor expression in luteinizing granulosa cells. J Clin Endocrinol Metab 1991;73:584-9.
22. Hild-Petito S, Stouffer R, Brenner R. Immunocytochemical localization of estradiol and progesterone receptors in the monkey ovary throughout the menstrual cycle. Endocrinology 1988;123:2896-905.
23. Suzuki T, Sasano H, Tamura M, Aoki H, Fukaya T, Yajima A, Nagura H, Mason I. Temporal and spatial localization of the steroidogenic enzymes in premenopausal human ovaries: in situ hybridization and immunohistochemical study. Mol Cell Endocrinol 1993;97: 135-43.
24. Wiebe H, Morris C. Effect on an oral contraceptive on adrenal and ovarian androgenic steroids. Obstet Gynecol 1984;63:12-14.
25. Inkster S, Brodie A. Expression of aromatase cytochrome P-450 in premenopausal and postmenopausal human ovaries: an immunohistochemical study. J Clin Endocrinol Metab 1991;73:717-26.
26. Soules M, Steiner R, Clifton D, Cohen N, Aksel S, Bremner W. Progesterone modulation of pulsatile luteinizing hormone secretion in women. J Clin Endocrinol Metab 1984;58:378-83.
27. Wildt L, Hausler A, Marshall G, Hutchison J, Plant T, Belchetz P, Knobil E. Frequency and amplitude of gonadotropin-releasing hormone stimulation and gonadotropin secretion in the rhesus monkey. Endocrinology 1981;109:376-85.
28. Krey L, Padmanabhan V, Beitins I. Progesterone modulation of gonadotropin secretion by dispersed rat pituitary cells in culture. IV. Follicle-stimulating hormone synthesis and release. Mol Cell Endocrinol 1993;91:13-20.
29. Poindexter A, Didly A, Brodyand S, Snabes M. The effects of a long-acting progestin on the hypothalamic-pituitary-ovarian axis in women with normal menstrual cycles. Contraception 1993;48:37-45.
30. Coutzinet B, Schaison G. The control of gonadotropin secretion by ovarian steroids. Hum Reprod 1993;8:97-101.
31. Ortmann O, Catt K, Schulz KD, Emons G. Modulatory action of progesterone and progesterone antagonist on hypothalamic-pituitary function. Hum Reprod 1994;9: (Suppl)53-62.
32. Coutzinet B, Brailly S, Bouchard P, Schaison G. Progesterone stimulates luteinizing hormone secretion by acting directly on the pituitary. J Clin Endocrinol Metab 1992;74:374-8.
33. Batista M, Cartledge T, Zellmer A, Nieman L, Loriaux L, Merriam G. The antiprogestin RU486 delays the midcycle gonadotropin surge and ovulation in gonadotropin-releasing hormone-induced cycles. Fertil Steril 1994;62:28-34.
34. Dubourdieu S, Charbonnel B, d'Acremont MF, Carreau S, Spitz I, Bouchard P. Effect of administration of a gonadotropin-releasing hormone (GnRH) antagonist (NalGlu) during the periovulatory period: the luteinizing hormone surge requires secretion of GnRH. J Clin Endocrinol Metab 1994;78:343-7.
35. Xia L, van Vugt D, Alston E, Luckhaus J, Ferin M. A surge of gonadotropin-releasing hormone accompanies the estradiol-induced gonadotropin surge in the rhesus monkey. Endocrinology 1992;131:2812-20.
36. Lahteenmaki P, Lahteenmaki P. Concentration dependent mechanism of ovulation inhibition by the proges-tin ST-1435. Fertil Steril 1985;44:20-24.
37. Lahteenmaki P, Weiner E, Lahteenmaki P, Johansson E, Luukkainen T. Contraception with subcutaneous capsules containing ST-1435. Pituitary and ovarian function and plasma levels of ST-1435. Contraception 1981; 23:63-75.
38. Ledger W, Sweeting V, Hillier H, Baird D. Inhibition of ovulation by low dose mifepristone (RU486). Hum Reprod 1992;7:945-50.
39. Croxatto H, Salvatierra AM, Croxatto H, Fuentealba B. Effects of continuous treatment with low dose mifepristone throughout one menstrual cycle. Hum Reprod 1993;8:201-7.